Navigation Links
Results of the STACCATO Trial reported at TCT 2011
Date:11/10/2011

SAN FRANCISCO, CA NOVEMBER 10, 2011 Researchers leading a clinical trial said that transapical transcatheter aortic valve implantation (a-TAVI) may be inferior to surgical aortic valve replacement (SAVR) in operable elderly patients. However results were only preliminary as the trial was carried out on 70 patients out of a planned 200 before it was terminated early for safety concerns. Results from the STACCATO trial were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

TAVI has become a treatment option for patients with aortic valve stenosis, who are not amenable or at high risk to SAVR. The goal of the STACCATO trial was to compare a-TAVI with SAVR in operable elderly patients.

Researchers planned a 1:1 randomization of 200 unselected operable AVS patients with no need for revascularization and aged ≥ 75 years. The primary endpoint was the composite of death, stroke and/or renal failure at 30 days. Two Danish university centers participated after more than 40 TAVI procedures had been performed with good results at each center.

After inclusion of 70 patients (34 apical TAVI, 36 SAVR), the study was terminated after advice from the Data Safety Monitoring Board, because of an excess of events in the apical TAVI group. Baseline characteristics were similar in the two groups. The primary endpoint was met in five TAVI patients (two deaths, two major strokes, and one case of renal failure) compared to one stroke in the SAVR group.

"In its present phase of development, transapical transcatheter aortic valve implantation may be inferior to surgical aortic valve replacement in operable elderly patients," said Leif Thuesen, MD, the lead investigator of the trial. Dr. Thuesen is from the Department of Cardiology at Aarhus University Hospital in Denmark.

Researchers noted that after study termination, these procedures have been optimized by routine preoperative multi-slice computed tomography (MSCT) assessment and by the availability of the 29 mm valve. Further improvement is likely to take place with improved devices and pre-procedure assessment, they said.


'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. Results of the DEB-AMI Trial reported at TCT 2011
2. Results of the RIFLE STEACS clinical trial reported at TCT 2011
3. Results of the PARTNER Trial Cohort B 2-year follow up presented at TCT 2011
4. Results of the PARTNER Trial Cohort A cost effectiveness analysis reported
5. Combination epigenetic therapy clinical trial results
6. Results of the PARIS registry Reported at TCT 2011
7. Results of the TRIGGER-PCI trial reported at TCT 2011
8. Results of rapid gene trial reported at TCT 2011
9. Results of the BRIDGE trial reported at TCT 2011
10. First results of Angiomax (bivalirudin) vs. heparin in transcatheter aortic valve interventions
11. Osteoarthritis results from inflammatory processes, not just wear and tear, Stanford study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... , ... Coast Dental has a new way to help parents keep their ... dentist Yvonne Dorrian, DMD, is hosting a free seminar on Friday, February 19 from ... at 1207 North Peachtree Parkway in Peachtree City. Dr. Dorrian will have healthy snacks, ...
(Date:2/8/2016)... Dallas, Texas (PRWEB) , ... February 08, 2016 , ... The Valentine’s Season is famous ... family members and significant others that they are loved. This year, for more than ... much they cost - just won't be enough to remind them of the lives they’ve ...
(Date:2/8/2016)... ... 2016 , ... Brenton Engineering , powered by Pro ... wrapped products at WestPack 2015, February 9-11, in Anaheim, California. This new solution ... or fully-automatic case packing with a small footprint, rugged, highly flexible, and cost-effective ...
(Date:2/8/2016)... ... 2016 , ... Tingley Rubber Corporation , a leading ... range of unique and advantaged protective solutions to a growing and dynamic ... customer service and marketing support. A new distribution center in Brampton, Ontario will ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Bell ... selected the latest beneficiary of their ongoing community enrichment program. The current campaign ... area schools. Donations are now being accepted at: http://www.angelsanddoves.com/donate.html . , Angels ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... PUNE, India , February 8, 2016 ... to a new market research report "Ablation Technologies Market ... Application (Csardiovascular, Cancer, Pain Management, Cosmetic Surgery, Ophthalmology, Gynecology) ... report studies the global market over the forecast period ... reach $4.44 Billion by 2020, at CAGR of 10.5% ...
(Date:2/8/2016)... In a historic vote among its members this weekend, the Shinnecock Indian ... facility and dispensary on tribal land near Southampton . ... provider for patients in the state,s Medical Cannabis Program. --> ... patients in the state,s Medical Cannabis Program. --> Tribal ... pursue designation from the State of New York ...
(Date:2/8/2016)... http://www.researchandmarkets.com/research/x6mkjm/knee ) has announced ... Market by Product Type (Primary (Cemented & Cementless), ... Eu-5, Japan, Bric, Turkey, Indonesia - Global Analysis ... offering. --> http://www.researchandmarkets.com/research/x6mkjm/knee ) has ... Devices Market by Product Type (Primary (Cemented & ...
Breaking Medicine Technology: