Navigation Links
Results of the ROTAXUS trial reported at TCT 2011
Date:11/11/2011

SAN FRANCISCO, CA NOVEMBER 11, 2011 A clinical trial testing the efficacy of rotational atherectomy (or rotablation, a process of drilling through plaque deposits) prior to implantation of a drug-eluting stent found that the process was not superior to standard balloon angioplasty and decreased the efficacy of the stent in reducing new tissue growth within the blood vessel.

Results of the ROTAXUS (A Prospective, Randomized Trial of High-Speed Rotational Atherectomy Prior to Paclitaxel-Eluting Stent Implantation in Complex Calcified Coronary Lesions) trial were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

Drug-eluting stents (DES) are liberally used in complex lesions and patients. Heavily calcified stenoses have not been adequately studied, and form a challenge for immediate and late outcomes. Rotational atherectomy has been shown to effectively modify calcified plaques and facilitate stent delivery and expansion. However, in the DES era, data concerning rotational atherectomy are scarce. In patients with complex calcified lesions, rotablation followed by DES seems a rational combination, but is not supported by randomized studies.

ROTAXUS is a randomized active-controlled superiority trial in patients with documented myocardial ischemia and complex calcified native coronary lesions. Eligible patients who met all clinical and angiographic inclusion criteria and gave written informed consent were randomized 1:1 to a strategy of rotablation followed by stenting, or stenting without prior rotablation (standard therapy). Stenting was performed using the polymer-based slow-release paclitaxel-eluting stent. The primary endpoint of the trial was the in-stent late lumen loss at nine months as measured by follow-up angiography.

240 patients with complex calcified coronary artery disease were enrolled at three investigator sites in Germany, and were assigned to be treated with rotablation followed by stenting (n=120) or stenting without rotablation (n=120).

At nine months, in-stent late lumen loss in the rotablation group was 0.44 mm and 0.31 mm in the standard therapy group. The rotablation group performed better than the standard therapy group in some areas, including acute lumen gain and strategy success (i.e. angiographic success without stent loss or cross-over).

"The superior acute gain obtained by rotablation counterbalanced the increased late loss resulting in a neutral effect on restenosis," said Gert Richardt, MD, PhD, the Study Chair. Dr. Richardt is a Professor at the Heart Center, Segeberger Kliniken in Germany.

"Rotablation remains an important bail-out device for uncrossable or undilatable coronary lesions but does not improve efficacy of DES in complex calcified lesions." Dr. Richardt said.


'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. Results of the ADVISE trial reported at TCT 2011
2. Results of the COBRA trial reported at TCT 2011
3. Results of the PROFI study reported at TCT 2011
4. Results of the EVOLVE trial reported at TCT 2011
5. Results of the REMEDEE trial reported at TCT 2011
6. Results of the NEXT clinical trial Reported at TCT 2011
7. Results of the PEPCAD-DES trial reported at TCT 2011
8. Results of the STACCATO Trial reported at TCT 2011
9. Results of the DEB-AMI Trial reported at TCT 2011
10. Results of the RIFLE STEACS clinical trial reported at TCT 2011
11. Results of the PARTNER Trial Cohort B 2-year follow up presented at TCT 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2019)... ... ... DOROT hosts its annual Rosh Hashanah Package delivery on Sunday, September 22nd at 10 am. ... out to visit our seniors. , , The Upper West Side ... Synagogue 123 East 55st Street , & Westchester at Young Israel of Scarsdale ...
(Date:9/17/2019)... (PRWEB) , ... September 17, 2019 , ... Milwaukee-area dealership Hall Cars has hosted an ... affected by cancer. The event, entitled “Drive Out Cancer,” entails that for every vehicle purchased ... Tomorrow Foundation. As the event lasts for 50 days, it has also been referred to ...
(Date:9/17/2019)... , ... September 17, 2019 , ... ... for Europe and the 21st Century Cures Act in the US, Nocimed has ... and pain management. Using images from existing MRI equipment to perform MR ...
(Date:9/17/2019)... ... September 17, 2019 , ... Drs. Charles Felts and ... teeth in Chattanooga, TN for customized full mouth dental implants with TeethXpress® ... one day, providing a permanent tooth replacement solution for patients who struggle with ...
(Date:9/17/2019)... , ... September 17, 2019 , ... Lubin Austermuehle, ... fundraiser. Gather for GRIN2B will be held at Found Kitchen and Social ... Proceeds will help fund research on GRIN2B-Related Neurodevelopmental Disorder, a rare condition that results ...
Breaking Medicine News(10 mins):
(Date:9/18/2019)... ... September 18, 2019 , ... Lake Minnetonka ... the launch of its new Hybrid-Responsive™ website: https://www.lakeminnetonkaortho.com . , The ... that allows patients to interact with the practice more easily online. Improvements include ...
(Date:9/18/2019)... (PRWEB) , ... September 18, ... ... parent organization to ReachMD, Global Learning Collaborative, and other healthcare-focused subsidiaries, today ... environment, DecisionSim™, uses real-world cases to challenge healthcare professionals (HCPs) to make ...
(Date:9/18/2019)... ... , ... The interns of NJ Lenders Corp. recently spent their time giving ... (YCS) in Hackensack , where NJ Lenders donated $1,000 worth of school supplies for ... a pizza party and handed out ice cream. , NJ Lenders is a part ...
Breaking Medicine Technology: