Navigation Links
Results of the PARTNER Trial Cohort B 2-year follow up presented at TCT 2011
Date:11/10/2011

SAN FRANCISCO, CA NOVEMBER 10, 2011 A two-year study of patients in the landmark PARTNER trial, which compared transcatheter aortic valve replacement (TAVR) in patients who have severe aortic stenosis and are not candidates for open heart surgery, confirm the one-year findings and support the role of TAVR as the standard of care.

Trial results were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

Cohort B of the PARTNER trial those patients with severe aortic stenosis who were not candidates for surgery - randomized 358 patients to transfemoral TAVR with an early generation balloon-expandable bovine pericardial valve or standard therapy (ST, including balloon valvuloplasty) at 21 centers, emphasizing a multi-disciplinary heart team approach.

The primary end point was death from any cause at one year and secondary endpoints included symptom status, serial echo assessments (core lab) and early/late adverse events (e.g. strokes).

After two years, the rate of all cause mortality was 18.2% in the TAVR group and 35.1% in the standard therapy group. The rate of cardiovascular mortality was 13.2% in the TAVR group and 32.1% in the standard therapy group.

The rate of repeat hospitalization was 35.0% in the TAVR group and 72.5% in the standard therapy group.

The rate of stroke at two years was higher 13.8% in the TAVR group and 5.5% in the standard therapy group.

"At two years, in patients with symptomatic severe aortic stenosis who are not suitable candidates for surgery, TAVR remained superior to standard therapy with incremental benefit from one to two years markedly reducing the rates of all cause mortality, cardiovascular mortality and repeat hospitalization," said Raj R. Makkar, MD, the principal site investigator for the PARTNER trial. Dr. Makkar is Director of Interventional Cardiology and the Cardiac Catheterization Laboratory at Cedars-Sinai Medical Center and Associate Director of the Cedars- Sinai Heart Institute

"There were more neurologic events in TAVR patients compared to standard therapy (16.2% vs. 5.5%; p = 0.003) with five new events (three strokes and two TIAs) between 1-2 years in TAVR patients. After 30 days, differences in stroke frequency were largely due to increased hemorrhagic strokes in TAVR patients." Dr. Makkar said.

"Two year data continues to support the role of TAVR as the standard-of-care for symptomatic patients with aortic stenosis who are not surgical candidates," said Dr. Makkar.

"The ultimate value of TAVR in 'inoperable' patients will depend on careful selection of patients who are not surgical candidates, and yet do not have extreme co-morbidities that overwhelm the benefits of TAVR."


'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2009 Financial Results
2. SXC Health Solutions to Host Fiscal 2009 Fourth Quarter and Year End Results Conference Call
3. Team Health Holdings, Inc., Announces Fourth Quarter and Fiscal 2009 Financial Results
4. First blinded study of venous insufficiency prevalence in MS shows promising results
5. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
6. BioMed Realty Trust Reports Fourth Quarter and Full-Year 2009 Financial Results
7. Kaiser Foundation Health Plan and Hospitals Report Fourth Quarter and Fiscal Year 2009 Financial Results
8. United American Healthcare Corporation Announces Fiscal 2010 Second Quarter Results
9. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
10. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
11. WebMD Announces Fourth Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... San Francisco, CA (PRWEB) , ... February 08, 2016 , ... ... helped raise $792,000 to help combat pancreatic cancer. , Gary D. Radine, who recently ... who also was the American Cancer Society’s 2015 CEO of the Year , ...
(Date:2/8/2016)... ... 08, 2016 , ... Discover the Rocky Mountain region’s longest running and impressive ... Attendees also get to see the most incredible gardens and home improvement experts ... at the Colorado Convention Center - 700 14th St. Denver CO, is an exciting ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Guruji Mahendra Kumar ... 10th and 11th, 2016 in honor of his birthday on February 10th. During ... Mahendra Trivedi is known by over 250,000 people from over 40 different countries ...
(Date:2/7/2016)... ... February 07, 2016 , ... ... MyDecision™ empowers employers and organizations with the tools and information to lower the ... elements to cut the cost of providing employee healthcare benefits by as much ...
(Date:2/6/2016)... ... February 06, 2016 , ... Shark Finds and Kevin Harrington, ... a new DRTV campaign with Belly Bands. , Having a dog is great—except when ... puppy pads and find nothing works, get Belly Bands, the easiest way to ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 2016 http://www.researchandmarkets.com/research/fqx6nz/global_skin ) ... Skin Protective Equipment Market 2016-2020" report to ... ) has announced the addition of the ... to their offering. --> ... the addition of the "Global Skin Protective ...
(Date:2/8/2016)... , Feb. 8, 2016   HighPoint Solutions ... Group (NRG),s pharmacovigilance technology services division.  NRG ... services and an Oracle Argus Specialized partner, providing ... Life Sciences companies. --> ... HighPoint,s life sciences capabilities and provides a global ...
(Date:2/8/2016)... , Feb. 8, 2016 ... the "Knee Reconstruction Devices Market by Product ... Implants), and Geography (U.S., Canada, Eu-5, Japan, Bric, ... 2020" report to their offering. ... of the "Knee Reconstruction Devices Market by ...
Breaking Medicine Technology: