Navigation Links
Results of the PARTNER Trial Cohort A cost effectiveness analysis reported
Date:11/10/2011

SAN FRANCISCO, CA NOVEMBER 10, 2011 The cost effectiveness of transcatheter aortic valve implantation (TAVR) compared to surgical aortic valve replacement (SAVR) depends on whether TAVR is performed via the femoral artery or transapically, through a small incision in the chest, according to a new study.

Recently, transcatheter aortic valve implantation (TAVR) has been shown to result in similar 12-month survival as surgical aortic valve replacement (SAVR) for high-risk patients with severe aortic stenosis. The potential cost-effectiveness of TAVR versus SAVR in the PARTNER trial was examined and the results were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

The PARTNER trial randomized patients with severe, symptomatic aortic stenosis and high surgical risk to either TAVR (N=348) or SAVR (N=351) and followed them for a minimum of 12 months. Health state utilities were estimated using the EuroQOL (EQ-5D) at baseline, one, six, and 12 months. Detailed medical resource utilization data were collected on all study patients, and hospital billing data were collected for both index and follow-up hospitalizations for any cause from consenting U.S. patients.

The objectives of the study were to combine cost data with survival and Quality of Life (QoL) data to estimate the12-month cost-effectiveness of TAVR compared with AVR and to explore potential differences in costs and cost-effectiveness of TAVR vs. AVR for the transfemoral vs. transapical populations.

Among high risk aortic stenosis patients eligible for the transfemoral approach, TAVR, compared with surgical AVR:

  • Provided small but significant gains in 12 month quality-adjusted life expectancy (0.06 0.07 Quality Adjusted Life Years, QALYs)
  • Was associated with higher procedural costs but slightly lower index hospitalization and total 12 month costs

However, not all patients qualify medically for the transfemoral approach. Among patients only eligible for the transapical approach:

  • TAVR provided no increase (and possible decrease) in QALYs
  • TAVR increased procedural, index admission, and 12 month costs (by ~$10,000/patient)

"Results of this trial indicate that for patients with severe aortic stenosis and high surgical risk, transcatheter aortic valve replacement is an economically attractive and possibly dominant strategy compared with surgical aortic valve replacement, provided that patients are suitable for the transfemoral approach," said Matthew R. Reynolds, MD. Dr. Reynolds is Director of the Economics and Quality of Life Research Center at Harvard Clinical Research Institute (HCRI), an Assistant Professor of Medicine at Harvard Medical School and Associate Director of Electrophysiology at the Boston VA Health Care System.

"Current results for transcatheter aortic valve replacement via the transapical approach, compared with surgical aortic valve replacement, are unattractive from a health economic perspective," said Dr. Reynolds.

"Whether the transapical approach can be refined to provide faster recovery and better results from a cost perspective should be the subject of further study."


'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. Combination epigenetic therapy clinical trial results
2. Results of the PARIS registry Reported at TCT 2011
3. Results of the TRIGGER-PCI trial reported at TCT 2011
4. Results of rapid gene trial reported at TCT 2011
5. Results of the BRIDGE trial reported at TCT 2011
6. First results of Angiomax (bivalirudin) vs. heparin in transcatheter aortic valve interventions
7. Osteoarthritis results from inflammatory processes, not just wear and tear, Stanford study suggests
8. E-counselling shows dramatic results in lowering blood pressure
9. Less Frequent Mammograms May Lower False-Positive Results
10. Mayo Clinic wins grant to study ethics of sharing genetic test results with relatives
11. TGen/Virginia G. Piper Cancer Center publish results of new drug for pancreatic cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... Retinal Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June 4, ... the public. , Dr. Maisel, founder of Retina Group of New York ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... of comprehensive treatment for eating disorders, is opening a brand new child and ... individuals ages 8-17 and their families with even more specialized eating disorder treatment ...
(Date:5/26/2016)... ... ... The MIAMI Institute for Age Management and Intervention celebrates Global Wellness Day with ... Adonis , Wellness Physician of the MIAMI Institute is certified by the American Academy ... , He also heads up FITTLab, the comprehensive medical testing lab located in The ...
(Date:5/26/2016)... Grants Pass, OR (PRWEB) , ... May 26, 2016 , ... ... founder of Bio-Logic Aqua® Research Water Life Science® and international water advocate, was honored ... descendant of the women in ancient Egypt who knelt on the banks of the ...
(Date:5/26/2016)... ... May 26, 2016 , ... Saint Francis ... several years, and the efforts have paid off. Since implementation of these ... of care to enhance perioperative patient experiences and reduce costly complications. Since implementation ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 MedDay, a biotechnology company focused ... oral presentation entitled "High doses of biotin in progressive multiple ... given by Professor Ayman Tourbah , Principal Investigator of ... European Academy of Neurology (EAN) in Copenhagen, Denmark ... will take place on Sunday, 29 May 2016 from 14:45 ...
(Date:5/24/2016)... 2016 Cirujanos holandeses han puesto ... los médicos a compartir sus mejores prácticas por el ... Profesionales médicos de Europa, África, Asia ... la aplicación, que combina la transmisión en vivo con ... Educación   "Imagine un médico de ...
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
Breaking Medicine Technology: