Navigation Links
Results of the EVOLVE trial reported at TCT 2011
Date:11/11/2011

SAN FRANCISCO, CA NOVEMBER 11, 2011 A clinical trial has established the non-inferiority of a drug-eluting stent with a bioabsorbable polymer compared to a drug-eluting stent with a durable polymer. Results of the EVOLVE clinical trial were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

Durable polymer coatings on drug-eluting stents have been associated with chronic inflammation and impaired healing. Bioabsorbable polymer-coated drug-delivery systems may reduce the risk of late events, including stent thrombosis, and the need for prolonged dual antiplatelet therapy.

The EVOLVE trial is a prospective, multi-center, randomized, single blind, first in-human non-inferiority trial. Subjects were randomized 1:1:1 to either of two formulations of a stent (full or one-half dose) with the bioabsorbable polymer and a standard drug-eluting stent.

The primary clinical endpoint was the 30-day rate of target lesion failure, defined as cardiac death related to the target vessel (TV), myocardial infarction related to the TV, or target lesion revascularization. The primary angiographic endpoint was 6-month in-stent late loss.

A total of 291 subjects were enrolled in the EVOLVE trial between July 29, 2010 and January 20, 2011 at 29 sites in Europe, Australia, and New Zealand. The mean subject age was 63 years, 73.1% were male, and 19.3% had medically treated diabetes.

In the bioabsorbable stent group with the full dose (n= 94), late loss at six months was .10 mm and 30-day target lesion failure was 1.1%. In the bioabsorbable stent group with dose (n=99), late loss at six months was 0.13 mm and 30-day target lesion failure was 3.1%.

These results compare to the use of a traditional drug-eluting stent (n=98), in which late loss at 6 months was .15 mm and 30-day target lesion failure was 0%.

"Clinical events were low and comparable with no stent thromboses in any group," said lead investigator, Ian T. Meredith, MBBS, PhD. Dr. Meredith is Professor and Director of Monash HEART and Executive Director of Monash Cardiovascular Research Centre at Monash Medical Centre and Monash University in Melbourne, Australia.

"These results support the safety and efficacy of the novel abluminal bioabsorbable polymer everolimus-eluting stent for the treatment of patients with de novo coronary artery disease. Additional research is needed to evaluate clinical event rates and the potential for dual antiplatelet therapy reduction with this novel stent. " said Prof. Meredith.


'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. Results of the REMEDEE trial reported at TCT 2011
2. Results of the NEXT clinical trial Reported at TCT 2011
3. Results of the PEPCAD-DES trial reported at TCT 2011
4. Results of the STACCATO Trial reported at TCT 2011
5. Results of the DEB-AMI Trial reported at TCT 2011
6. Results of the RIFLE STEACS clinical trial reported at TCT 2011
7. Results of the PARTNER Trial Cohort B 2-year follow up presented at TCT 2011
8. Results of the PARTNER Trial Cohort A cost effectiveness analysis reported
9. Combination epigenetic therapy clinical trial results
10. Results of the PARIS registry Reported at TCT 2011
11. Results of the TRIGGER-PCI trial reported at TCT 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... , June 24, 2016  Global Blood Therapeutics, ... company developing novel therapeutics for the treatment of ... announced the closing of its previously announced underwritten ... at the public offering price of $18.75 per ... were offered by GBT. GBT estimates net proceeds ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: