Navigation Links
Results of the ADVISE trial reported at TCT 2011
Date:11/11/2011

SAN FRANCISCO, CA NOVEMBER 11, 2011 Researchers conducting the ADVISE clinical trial have concluded that a new measure of stenosis severity, instantaneous wave-free ratio (iFR), yielded similar results to traditional fractional flow reserve (FFR) without the use of adenosine to induce maximum hyperemia. Trial results were presented today at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

FFR, while the leading invasive measure of stenosis severity, is only used in 6% or fewer of percutaneous coronary intervention (PCI) cases in the United States. One of the reasons for the low usage rate is the required use of the drug adenosine, which minimizes and stabilizes coronary resistance during the test, but is uncomfortable for patients, as well as being time-consuming and expensive.

In ADVISE (ADenosine Vasodilation Independent Stenosis Evaluation), 157 stenoses (131 patients) were recruited to this pilot, nonrandomized, international, multi-center study. In their investigations, researchers developed a new pressure-based index that does not require adenosine.

Wave intensity analysis identified a period during the normal heart rhythm cycle where intracoronary resistance at rest is similar in variability and magnitude (CV: 0.080.06 and 284147mmHg.s/m) to those during FFR (CV: 0.080.06 and 302315mmHg.s/m, p=NS for both).

The resting ratio of the distal-to-proximal pressure during this period, iFR, correlated closely with FFR (r=0.9, p<0.001) with excellent diagnostic efficiency (receiver operating characteristic area under curve of 93%, at FFR<0.8), specificity, sensitivity, and negative and positive predictive values of 91%, 85%, 85% and 91%, respectively.

"The results of the ADVISE trial indicate that intra-coronary resistance is naturally constant and minimized during the wave-free period. The instantaneous wave-Free Ratio (iF
'/>"/>

Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2009 Financial Results
2. SXC Health Solutions to Host Fiscal 2009 Fourth Quarter and Year End Results Conference Call
3. Team Health Holdings, Inc., Announces Fourth Quarter and Fiscal 2009 Financial Results
4. First blinded study of venous insufficiency prevalence in MS shows promising results
5. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
6. BioMed Realty Trust Reports Fourth Quarter and Full-Year 2009 Financial Results
7. Kaiser Foundation Health Plan and Hospitals Report Fourth Quarter and Fiscal Year 2009 Financial Results
8. United American Healthcare Corporation Announces Fiscal 2010 Second Quarter Results
9. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
10. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
11. WebMD Announces Fourth Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method ... lean muscle by up to 30lbs in less than 12 ... HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... scientific diet formula that allows the body to pack on ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota ... it means to “Live Fearless.” , The “Faces ... their stories about how they or someone they know has ... living in the moment. By telling these types of stories ...
(Date:1/22/2015)... York (PRWEB) January 22, 2015 The federal ... in the U.S. District Court, Southern District of West Virginia ... Inc. in that proceeding’s first bellwether trial. In an Order ... a new trial after finding that C.R. Bard had not ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 A ... issue of experience and person-centeredness in the long-term care ... towards action across the continuum. The paper, “The Power ... Continuum,” engages perspectives and practices of the patient, resident ...
(Date:1/22/2015)... 22, 2015 Autocarinsurancebest.com has released a new ... commercial auto insurance policy . , Auto insurance quotes ... It is no longer necessary to call an agent or ... available online on a single website: http://autocarinsurancebest.com/ . , ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Commercial Auto Insurance Provides Several Important Features! 2
... University is collaborating on the development of a potential ... An international team of Monash and international researchers ... (MMV) Project of the Year award in recognition of ... drug candidate for clinical testing. Tanzanian President Kikwete ...
... (ALS) could lose brain function earlier than is noticeably ... care. Physicians need a method to assess these sensitive ... neuropsychological tests. Penn State College of Medicine researchers ... deficits in judgment and problem-solving in ALS patients. FTD ...
... HealthDay Reporter , TUESDAY, June 21 (HealthDay News) -- In ... U.S. Food and Drug Administration on Tuesday released nine graphic warning ... later than September 2012. One image shows a man,s ... from a hole in his neck -- the result of a ...
... HOBOKEN, NJ A recent study published in ... Coenzyme Q10 (CoQ10) combination (PycnoQ10) taken by stable heart ... strengthens the heart, increasing the blood volume ejected with ... supply to the organs improves, and patients become more ...
... with prostate cancer and who are also smokers have ... cancer-specific death, according to a study in the June ... had an increased likelihood of prostate cancer recurrence. ... aggressive prostate cancer and prostate cancer mortality. However, studies ...
... Reporter , TUESDAY, June 21 (HealthDay News) -- When arranging ... ask if there are any unlocked guns in the prospective ... with kids contain unlocked, loaded guns, experts say, and dozens ... why the Center to Prevent Youth Violence (PAX) has joined ...
Cached Medicine News:Health News:Major malaria drug research award 2Health News:Brief exam diagnoses cognitive impairment in ALS patients 2Health News:FDA Unveils Graphic Images for Cigarette Packs 2Health News:FDA Unveils Graphic Images for Cigarette Packs 3Health News:FDA Unveils Graphic Images for Cigarette Packs 4Health News:Study shows pine bark naturally improves heart function 2Health News:Study shows pine bark naturally improves heart function 3Health News:Study shows pine bark naturally improves heart function 4Health News:Being a smoker at time of prostate cancer diagnosis linked with increased risk of death 2Health News:Making Sure Child's Play Doesn't Turn Into Gunplay 2Health News:Making Sure Child's Play Doesn't Turn Into Gunplay 3Health News:Making Sure Child's Play Doesn't Turn Into Gunplay 4
(Date:1/23/2015)... , Jan. 23, 2015  Pete Rose, baseball,s all-time hits ... and arthritis pain reliever Myoflex, Ducere Pharma has announced. ... we are excited to have him on board with Myoflex," ... "He is a legendary player who is known across all ...
(Date:1/23/2015)... 23, 2015  iMD Companies, Inc. (ICBU) has repositioned itself as ... and grab a foothold in the hydroponic, hemp and medical ... a presence in the sector, and recently partnering with the ... hemp and medical marijuana, iMD is committing to bring its ...
(Date:1/23/2015)... Jan. 23, 2015   Leatt Corporation  (OTCQB: LEAT), a ... for all forms of sports, including extreme motor sports, ... announced today that the UISP Lega Motociclismo Lombardia, an ... riders to wear a neck brace during its racing ...
Breaking Medicine Technology:Pete Rose bets on Myoflex to relieve aches and pains 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
... Nov. 22, 2011 Avanir Pharmaceuticals, Inc. (NASDAQ: ... the Piper Jaffray 23rd Annual Health Care Conference. ... Wednesday November 30, 2011 2:00 p.m. ET ... this presentation will be available at http://www.avanir.com . ...
... Board of Directors of BD (Becton, Dickinson and Company) (NYSE: ... per common share, an increase of 4 cents per share, or ... payable on December 30, 2011 to holders of record on December ... year 2012 would be $1.80 cents per share. ...
Cached Medicine Technology:BD Board Increases Dividend 2
... 14A and 14C have been approved. The three ... the variations in the size of the individual ... are designed to stabilize the capsule and have ... of U.S. ophthalmologists. For implatations of the ...
... is a device designed for permanent implantation ... removal surgery. It provides secondary capsular bag ... The CTR is a uniplanar, 270-degree, semi-circle ... absorbing polymethylmethacrylate (PMMA) with one manipulation eyelet ...
Stainless steel cartilage scissors....
Hannum rongeur/grasper with teth in jaws and non-locking design....
Medicine Products: