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Results From Landmark PROSPECT Trial Demonstrate the Ability of Volcano's VH(R) IVUS Imaging to Identify Plaques Most Likely to Cause Heart Attacks
Date:9/24/2009

rietary Eagle Eye Gold IVUS catheter not only visualizes and measures plaque burden but also collects signals for VH imaging allowing display of four plaque components.

Importantly, the absence of a fibroatheroma by PROSPECT definitions in imaged lesions was a strong predictor of lesion stability over three years as shown in the graph below. In lesions defined by PROSPECT having less than 10% Necrotic Core (red on VH IVUS), the likelihood of that lesion progressing to an event over three year was negligible, independent of other grayscale and angiographic factors.

It is widely believed that a hazard ratio of greater than 2.0 is a clinically meaningful predictor of an event. You can see from the chart below that the hazard ratio for a PROSPECT defined VH-TCFA is 3.8 with a p-value of < 0.0001 indicating a positive predictive value of causing an event that is statistically significant. The converse is true for PIT lesions which have a hazard ratio of only 0.2, indicating low likelihood of causing an event, which is also statistically significant.

"Healthcare reform has reached a boiling point," continued Huennekens. "The power of this study is quite simple: Angiography alone is not enough and we need more precise, targeted procedures. PROSPECT is not only important for identifying high-risk plaques so they can be treated to prevent future events. The findings are arguably just as important because they identify low-risk plaques, which do not need intervention which can decrease costs and future events. VH(R) IVUS is very different from non-invasive imaging technologies like CT and MRI, which have been accused of funneling too many procedures to the cath lab. In the case of IVUS, these patients are already in the cath lab, and are already getting an intervention. This tool simply allows physicians to further triage which lesions need to be stented, and which lesions can be treated with medical
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SOURCE Volcano Corporation
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