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Results From Landmark PROSPECT Trial Demonstrate the Ability of Volcano's VH(R) IVUS Imaging to Identify Plaques Most Likely to Cause Heart Attacks
Date:9/24/2009

i-bin/prnh/20090924/SF81669-e" target="_new">http://www.newscom.com/cgi-bin/prnh/20090924/SF81669-e)

"For years, interventional cardiologists have been focused on using angiography to identify blockages and to restore flow. PROSPECT teaches us that looking at the angiographic severity of the blockage is not enough, and we must understand the type of disease present in the vessel wall," said Gregg Stone, MD, of Columbia University Medical Center and Principal Investigator of PROSPECT. "With VH(R) IVUS we can clearly see two things: one, that "mild" lesions on angiography are capable of progressing quickly into events for the patient: and two, events also take place in locations of severe disease that are often missed by angiography. Understanding the risk of each lesion type is paramount to minimizing the occurrence of these future events. Current practice using angiography guidance alone is insufficient in that regard."

PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) is a first-of-its-kind multi-center, natural history study of acute coronary syndrome (ACS) patients. These patients underwent PCI to restore blood flow at baseline. Following the PCI procedure, an angiogram and a detailed IVUS image was captured in the three primary coronary arteries before the patient was sent home. If the patient had a subsequent event, they were readmitted, and again, an angiogram and IVUS imaging was performed. The core laboratory (Cardiovascular Research Foundation, New York, NY) then matched the location of the secondary event to the initial IVUS images to determine which locations progressed, and which lesions remained stable. Patient follow-up continued for three years.

"Angiography alone is not enough and more and more clinical data continues to support that conclusion," said Scott Huennekens, President and CEO of Volcano. "PROSPECT has shown that not all coronary dise
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SOURCE Volcano Corporation
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