Navigation Links
Restoring appropriate movement to immune cells may save seriously burned patients
Date:6/19/2013

Advances in emergency medicine and trauma surgery have had a significant impact on survival of patients in the days immediately after major injuries, including burns. Patients who survive the immediate aftermath of their injuries now are at greatest risk from infections particularly the overwhelming, life-threatening immune reaction known as sepsis or from inflammation-induced multiorgan failure. Now, a device developed by Massachusetts General Hospital (MGH) investigators that measures the movement of key immune cells may help determine which patients are at greatest risk for complications, and a novel treatment that directly addresses the cause of such complications could prevent many associated deaths.

"One in every three patients with burn injuries that dies in an intensive care unit does so because of septic complications," says Daniel Irimia, MD, PhD, of the MGH Department of Surgery, corresponding author of a report in the June FASEB Journal. "In the days immediately after injury, white blood cells called neutrophils can lose their ability to move to the site of an injury. In an animal model of burn injury, we found that death due to septic complications can be prevented by a treatment that restores the proper movement of neutrophils."

The most abundant type of white blood cell, neutrophils are part of the innate immune system and the body's first line of defense against infections. Normally, neutrophils are drawn towards the site of a infection by chemical signals from bacteria or injured cells. However, it has recently been discovered that in patients with serious burn injuries neutrophils' ability to follow these signals becomes impaired soon after the injury. Not only does that impairment reduce the availability of the cells to fight infection at the site of injury, but misguided neutrophils also can attack healthy tissue, contributing to organ failure. The current study was designed to analyze changes in the speed and direction of neutrophil movement after burn injury and to investigate whether recently identified molecules called resolvins, which normally act to terminate the inflammatory process after an infection has cleared, could also restore normal neutrophil motion after burns.

Using a microfluidic device that measures neutrophil movement developed at the MGH BioMEMS Resource Center, the investigators first confirmed that the ability of neutrophils from burn-injured rats to move towards a chemical signal of injury progressively deteriorates in both speed and accuracy as time passes. While cells from uninjured animals moved quickly and directly through a series of microchannels towards the injury signal, cells from blood samples taken 9 days after the injury became trapped in the device or reversed direction. The researchers then showed that application of resolvin D2 significantly improved the in vitro migratory ability of neutrophils from burned animals.

Experiments in living rats revealed that treatment with resolvin D2 restored appropriate neutrophil motion, an effect that lasted at least two days after treatment ended. In addition, when burn-injured animals were subjected to a second sepsis-inducing injury, treatment with resolvin D2 significantly increased survival. For example, in a group of rats injected with a bacterial toxin nine days after a burn injury, all of those pre-treated with resolvin survived, while all untreated animals died.

"Our ability to measure neutrophil movement in great detail gave us the information we needed to develop the optimal dosage and duration of resolvin treatment for the burned rats. Our results also indicate that neutrophil motility could be a useful biomarker for the actual risk of septic complications in patients," says Irimia, an assistant professor of Surgery at Harvard Medical School who is also affiliated with Shriner's Hospital for Children. "Our experiments in the animal model suggest that a resolvin-based treatment could prevent those complications by restoring the body's own resources, allowing it to respond to secondary infections, which could save hundreds of patients with burns every year. "


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. In Rat Study, Eye Device Shows Promise for Restoring Sight
2. Drug kills cancer cells by restoring faulty tumor suppressor
3. Prosthetic retina offers simple solution to restoring sight
4. RMAX International to donate Recuper8 - a free, health - restoring program to Everyone in Uniform
5. ACE, the Accreditation for Cardiovascular Excellence, Cited as Effective Program for Restoring Hospital Reputation
6. New technique shows promise in restoring near vision without glasses
7. PharmaNet system dramatically reduced inappropriate prescriptions of potentially addictive drugs
8. Study shows how to reduce inappropriate shocks from implanted defibrillators
9. Doctors call for evidence-based appropriateness criteria for elective procedures
10. ACC/HRS release appropriate use criteria for ICDs and CRT
11. Nearly a third of antibiotic prescriptions for dialysis patients inappropriate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... PA (PRWEB) , ... July 24, 2017 , ... Summer ... rain storms wreak havoc across communities and often result in massive tree damage requiring ... actions homeowners can take now including tree trimming, tree cabling and hazardous tree removal. ...
(Date:7/24/2017)... Falls Church, VA (PRWEB) , ... July 24, ... ... is figuring out how to change manufacturers future. , The agency is hammering ... Century Cures Act, one of the farthest-ranging laws ever to affect FDA-regulated firms. ...
(Date:7/24/2017)... ... July 24, 2017 , ... Advanced Dermatology, ... Bellmore, New York, (516) 784-5858. The office opened earlier this summer and is ... Friedman and Fruma Leah Wiederman. , Advanced Dermatology, P.C. founder and medical ...
(Date:7/24/2017)... ... 24, 2017 , ... “Nana Nana Boo Boo”: a delightful tale of a ... “Nana Nana Boo Boo” is the creation of published author Michael Rush, a Deputy ... Faith Publishing, Michael Rush’s new book presents the importance of manners in a way ...
(Date:7/24/2017)... ... ... “Journey to the Light: The Quest for Happiness and Love. . . ... finding herself. “Journey to the Light: The Quest for Happiness and Love. . ... of newsletters, manuals, and articles, who has recently decided to expand her literary horizons ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... Pace Analytical, a company of over 2,000 employees and a leader in environmental ... Sciences, further solidifying their position as the top American owned and operated environmental ... ... Analytical ... Mt Juliet, TN , enhances Pace Analytical,s capability as an innovative full ...
(Date:6/30/2017)... June 30, 2017 In vitro diagnostics market ... of May, at least ten diagnostic companies have successfully ... public offerings and a loan facility.  The size of ... $80 million.  Kalorama Information provides a monthly IVD ... Diagnostics Knowledge Center. ...
(Date:6/27/2017)... June 27, 2017  Therapix Biosciences Ltd. (Nasdaq: ... specializing in the development of cannabinoid-based drugs, today announced ... Opening Bell in New York, NY ... its initial public offering (IPO) of American Depository Shares ... 2017. Dr. Elran Haber, Ph.D., Chief Executive ...
Breaking Medicine Technology: