Navigation Links
Response to vaccines could depend on your sex
Date:5/12/2010

Biological differences between the sexes could be a significant predictor of responses to vaccines, according to researchers at the Johns Hopkins Bloomberg School of Public Health. They examined published data from numerous adult and child vaccine trials and found that sex is a fundamental, but often overlooked predictor of vaccine response that could help predict the efficacy of combating infectious disease. The review is featured in the May 2010 issue of The Lancet Infectious Diseases.

"Sex can affect the frequency and severity of adverse effects of vaccination, including fever, pain and inflammation," said Sabra Klein, PhD, lead author of the review and an assistant professor at the Bloomberg School's W. Harry Feinstone Department of Molecular Microbiology and Immunology. "This is likely due to the fact that women typically mount stronger immune responses to vaccinations compared to men. In some cases, women need substantially less of a vaccine to mount the same response as men. Pregnancy is also a factor that can alter immune responses to vaccines."

Researchers conducted a review of existing literature on several vaccines including yellow fever, influenza, measles, mumps and rubella, hepatitis and herpes simplex to obtain evidence of the difference in responses between women and men. They also examined the effect hormonal changes that occur during pregnancy have on vaccine efficacy. Researchers found that despite data supporting a role for sex in the response to vaccines, most studies did not document sex-specific effects in vaccine efficacy or induced immune responses.

"Understanding the biological differences between men and women to vaccines could have led to better distribution of the 2010 H1N1 vaccine during the early months. Our review of the literature found that healthy women often generated a more robust protective immune response to vaccination when compared to men," said Andrew Pekosz, PhD, associate professor at the Bloomberg School's W. Harry Feinstone Department of Molecular Microbiology and Immunology. "An understanding and appreciation of the effect of sex and pregnancy on immune responses might change the strategies used by public health officials to start efficient vaccination programs, optimizing the timing and dose of vaccines so that the maximum number of people are immunized." added Klein.


'/>"/>

Contact: Natalie Wood-Wright
nwoodwri@jhsph.edu
410-614-6029
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Related medicine news :

1. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
2. Babies Responses to Prenatal Stress Differ by Gender
3. A stress-response system in the ear protects against hearing loss
4. Patients whole genome reveals risk of diseases and adverse drug responses
5. Merely seeing disease symptoms may promote aggressive immune response
6. Protein in Breast Tumors May Predict Chemo Response
7. Bodys Response to Foods Smell, Taste Could Be Diabetes Risk Factor
8. NOW Foods Response to Fish Oil and PCB Concerns
9. Tips for Safe Charitable Giving in Response to Earthquakes in Chile and Haiti
10. International Medical Corps Emergency Response Team on Standby as It Monitors Situation in Chile and Potential Tsunami Areas
11. Aggressive response helped Chilean hospital improve H1N1 influenza outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... 2017 , ... Secure Exchange Solutions, the leading provider of ... health information exchanges, physicians and patients, announced today that SES Direct earned the ... IT Module Certification via Drummond Group LLC, an Authorized Certification Body (ACB). This ...
(Date:2/22/2017)... ... February 22, 2017 , ... In a 2012 survey, over ... not filling a prescription because they could not afford to pay for it. ... were 30-60%*. At the same time, hospitals, pharmacies, manufacturers and nursing ...
(Date:2/22/2017)... ... February 22, 2017 , ... Using the power of the ... simple online checklist. Over a period of just 24 months, thousands of individuals interested ... online checklist called T.A.D. , “The internet is not getting quieter. In fact it’s ...
(Date:2/22/2017)... ... 2017 , ... Bellus Medical, a leader in medical aesthetics, ... of Platelet Rich Plasma (PRP). PRP systems are used by physicians in areas ... and provide a faster and more efficient healing process. There are many systems ...
(Date:2/22/2017)... ... , ... Super-Sod will attend the Athens Home Show with a brand new ... from Super-Sod’s simple Athens Home Show booth of 2016, this year’s exhibit space includes ... Chris Roquemore constructed furniture from recycled pallet wood at the Super-Sod farm in Fort ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017  Corin Group announced today ... device used to treat patients with both a massive ... arthritis. The condition, known as cuff tear arthropathy, causes ... The Humelock Reversed Shoulder System, which ... technology company based near Lyon, France ...
(Date:2/22/2017)... , Feb. 22, 2017  Known for selling ... cabinets, the widow of prominent California ... should know something else about the British conglomerate that ... immorally by attempting to steal her late husband,s invention, ... and operated by Dr. Gilbert until his violent death ...
(Date:2/22/2017)... PUNE, India , February 22, 2017 /PRNewswire/ ... Allied Market Research, titled, "Radiology Information System Market by Type, ... Industry Forecast, 2014-2022," the radiology information system market was valued ... $941 million by 2022, growing at a CAGR of 5.9% ... held over three-fifths share of the total market in 2015. ...
Breaking Medicine Technology: