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Resisting lung cancer recurrence
Date:2/4/2008

he protein that marks the cell as being a cancer cell.

LICR and the Cancer Research Institute, both head-quartered in New York, supported the study under the auspices of the Cancer Vaccine Collaborative, with the clinical component conducted by Dr. Nasser Altorki at New York Presbyterian Hospital / Weill Medical College of Cornell University.

Cancer vaccines have two principal components. One component, the adjuvant, stimulates the immune system in a general way, and the other component, the tumor antigen in this case, the MAGE-A3 antigen directs the immune response specifically against the cancer cell. Last month, another LICR-sponsored clinical trial within the Cancer Vaccine Collaborative showed that a cancer vaccine based on the tumor antigen NY-ESO-1 stimulated an immune response in women with ovarian cancer. The results from that trial were suggestive that a similar boost strategy could be beneficial for long-term immunological memory in that disease also.

A completely unexpected finding from the present study was that the inital formulation and delivery of the tumor antigen to the immune system is critical and suggests that the combination of the antigen with an immunological adjuvant is key. The original, small clinical study, conducted three years ago by the Cancer Vaccine Collaborative, showed that the adjuvant was necessary for activation of the immune system; patients who received antigen alone failed to mount specific immune responses. Surprisingly, these same patients also failed to mount immune responses even when they received the full vaccine adjuvant plus antigen as a booster shot.

This is such a surprising result, says LICRs Dr. Lloyd Old, another author on the study and Director of the Cancer Vaccine Collaborative. In the vaccine field, boosters are given to convert negative or weak reactions to positive ones, and we really thought we would see the same thing. One intriguing possibility is that regulator
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Contact: Sarah L. White, Ph.D.
swhite@licr.org
917-379-0398
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2 3

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