Navigation Links
'Resistance' to low-dose aspirin therapy extremely rare
Date:12/5/2012

PHILADELPHIA Roughly one-fifth of Americans take low-dose aspirin every day for heart-healthy benefits. But, based on either urine or blood tests of how aspirin blocks the stickiness of platelets blood cells that clump together in the first stages of forming harmful clots up to one third of patients are deemed unlikely to benefit from daily use. Such patients are called "aspirin resistant." Clots are the main cause of most heart attacks and strokes.

In people who have suffered a heart attack, low-dose aspirin reduces the chances of a second event by about one fifth, making it perhaps one of the most cost-effective drugs currently prescribed. Although consumed widely by the worried well, the relative usefulness of low-dose aspirin in patients who have never had a heart attack is more controversial. According to previous primary prevention studies, low-dose aspirin reduces this group's very low risk of a first attack by about the same number of serious stomach bleeds it causes.

In a study of 400 healthy volunteers published online this week in Circulation, the journal of the American Heart Association, scientists from the Perelman School of Medicine at the University of Pennsylvania, went looking for people who are truly resistant to the benefits of aspirin, such as might result from a particular genetic makeup. They failed to find one case of aspirin resistance; rather, they found "pseudoresistance," due to the coating found on most brands of aspirin, often preferred by patients for the protection it is claimed to provide the stomach. What's more, a urine biomarker of platelet stickiness was not able to find which volunteers were even pseudoresistant.

The study was led by Tilo Grosser MD, research assistant professor of Pharmacology, Susanne Fries, MD, research assistant professor of Pharmacology, and Garret FitzGerald, MD, FRS, director of the Institute for Translational Medicine and Therapeutics.

"When we lo
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New drug overcomes resistance in patients with rare sarcoma
2. Drug resistance biomarker could improve cancer treatment
3. Many Americans Still in the Dark About Antibiotic Resistance
4. Understanding antibiotic resistance using crystallography and computation
5. Recent findings may help to fight melanomas resistance to chemotherapy
6. Scripps Research Institute receives $20 million to shed light on HIV drug resistance
7. UCI researchers find cause of chemotherapy resistance in melanoma
8. Mutation breaks HIVs resistance to drugs
9. Protein linked to therapy resistance in breast cancer
10. New Strep Throat Guidelines Tackle Antibiotic Resistance
11. Environmental Gene-Swapping May Play Part in Antibiotic Resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Resistance' to low-dose aspirin therapy extremely rare
(Date:1/22/2015)... 2015 The federal court overseeing thousands of ... Court, Southern District of West Virginia has upheld a $2 ... first bellwether trial. In an Order dated January 21st, the ... finding that C.R. Bard had not proven a miscarriage of ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
(Date:1/22/2015)... 2015 As interest in the value of ... momentum worldwide, Rev. Eric J. Hall , president and ... (HCCN), will be the keynote speaker on January 27 at ... health system. , The conference, “Hope and Resilience: Innovative and ...
(Date:1/22/2015)... State Forestry Institute of Mecklenburg-Vorpommern in ... support from GEOSYSTEMS, a dedicated Hexagon Geospatial and Intergraph ... Hexagon Geospatial’s ERDAS APOLLO for cataloging, managing, ... point clouds and documents. This effort will enable the ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... which are a risk factor for diabetes and heart disease ... research from Wake Forest University Baptist Medical Center. Early results ... to the equation. ,“The message is very clear,” said ... Baptist and lead author. “Exercise is important to reducing the ...
... Minister V.S. Achuthanandan to immediately ban the sale of Coke ... may finally get its due. ,Despite the healthy, nourishing ... have been low. Now, with the controversy over the pesticide ... a furore again, the government is going to redouble efforts ...
... the presence of drugs and not the intoxication or damage caused ... will affect their performance? // Probably not," says Paul Dillon of ... for instance, detection could mean the impairment is from quite a ... month) and really has no effect on them at the time." ...
... tend to nap after a heavy lunch. When people are ... in the brain send signals that keep a person alert. ... prevents the nerve cells from sending alert signals and hence ... that when the body needs fuel in form of glucose, ...
... looks awful. Worse, it's a real possibility for men who smoke.// ... the papilla on the tongue, normally only one mm in length, ... brown, says Joachim Dissemond of the University of Essen. It occurs ... stem from a disturbance in the immune system that allows bacteria ...
... A balance is needed between geographic convenience and the ... patients in remote areas, according to an article// in ... (MJA). ,There is a developing trend towards ... to maintain service quality and care standards. ...
Cached Medicine News:Health News:Exercise Important in Reducing Size of Abdominal Fat Cells 2Health News:Bolster Rural Surgical Services 2
(Date:1/23/2015)... LONDON and BOSTON , January ... structure-guided drug discovery and development company, is delighted to announce ... has been awarded to Miles Congreve (Vice President ... co-founder) and Malcolm Weir (Chief Executive Officer and ...
(Date:1/22/2015)...  BiOptix is pleased to announce the appointment of Dr. ... and Biochemistry. Scott joins the company after previous scientific leadership ... the course of his nearly 20 year career in ... nationally recognized thought leader in the biosensor field and ...
(Date:1/22/2015)... 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the ... therapies for cardiovascular disease and overall health is pleased to ... 2014 and its outlook for 2015 from the CEO, Mr. ... We would like to take this opportunity to share ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
...  BSI,s Healthcare Solutions Group is hosting a free webinar on ... is scheduled for January 26 and is intended to address ... how to be prepared. (Logo: http://photos.prnewswire.com/prnh/20110405/NE77664LOGO ... to help the audience understand the current status and upcoming ...
... (Nasdaq: CDXS ) today announced that the Company,s ... his decision to resign as Chief Financial Officer in order ... Board of Directors will conduct an immediate search for a ... contributions to Codexis," said Alan Shaw, Ph. D, President and ...
Cached Medicine Technology:FREE Webinar: Revision of the In Vitro Diagnostic Directive 2
HemoNIR™ is a portable device that measures the ability of apersons blood to carry oxygen by monitoring functional vs. non functional hemoglobin....
... real-time PCR analysis of gene expression ... LightCycler 480 System combines amazing speed ... the needs of a broad range ... including array validation, gene-knockdown studies, and ...
... Vivid 3 - Vivid family system ... level of cardiovascular performance, and offer an ... vascular, pediatrics and the OR. , ,From ... to DICOM connectivity, the new Vivid 3 ...
... Wireless, internet-based ... provides compliance and ... complete system. The ... System incorporates communication ...
Medicine Products: