Navigation Links
Researchers work to take the pressure off newborns' lungs
Date:7/27/2011

AUGUSTA, Ga. Children born with heart defects that pummel their lungs with up to three times the normal blood volume quickly find their lungs in jeopardy as well.

Georgia Health Sciences University researchers are working to take the pressure off by augmenting a natural recycling system that enables blood vessels to temporarily handle the extra workload until the heart problem is resolved.

They've found that system isn't getting enough energy to generate sufficient nitric oxide, the powerful blood vessel dilator. But drugs called PPAR agonists, already in use for adult lung injury and to lower blood glucose and lipids in diabetes, may provide the boost small, fragile blood vessels need.

"Our goal is to help protect the babies' lungs until their heart defect can be corrected," said Dr. Shruti Sharma, molecular biologist at GHSU's Vascular Biology Center. About 1 percent of newborns have a heart defect with half requiring surgery. Improved surgical and medical treatments have increased survival rates but the risk of related lung disease also can be deadly as the high blood flow turns flexible pulmonary blood vessels into narrow, rigid pipes. The result, pulmonary hypertension, also puts additional strain on the heart.

Sharma is principal investigator on a four-year American Heart Association grant to better define key steps of the recycling system and whether increasing PPAR signaling can help restore optimal functioning of the system when it's needed most.

It's known that the amino acid arginine interacts with nitric oxide synthase to form nitric oxide and while these babies have plenty of arginine, they can't access it. Studies at GHSU and elsewhere have shown that the arginine found in the endothelial cells which line blood vessels are most important for nitric oxide generation. That's where recycling comes in.

Under normal conditions, arginine helps nitric oxide synthase produce nitric oxide as well
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers work to take the pressure off newborns' lungs
(Date:9/21/2014)... 2014 Expert witness work is in! ... from its 2014 Expert Witness Fees & Practices Survey. ... demand and compensation for qualified and credentialed expert witnesses ... 16-year history. , The nearly 600 experts surveyed ... expert work, an increase of 3.2% from ExpertPages’ 2012 ...
(Date:9/21/2014)... "I wanted to be able to obtain ... foul-tasting energy drinks," said an inventor from Fresh Meadows, ... drink plain, old coffee. That is why I came ... ENERG CHEWING GUM to provide a healthy energy boost ... contains nutritious vitamins, minerals and antioxidants. It also features ...
(Date:9/21/2014)... September 21, 2014 "I want to ... and back but haven’t the money for chiropractors," said ... to have such a product for myself." , The ... to stretch the thigh muscles and align the spine ... as relieves discomfort of pinched nerves. Compact and easy ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 Best Cheap ... recently announced that Arvixe, Bluehost and GreenGeeks are the ... to find a good reseller hosting supplier. Actually, these ... server speed and customer support. People can get the ... manager says. , According to the manager, reseller ...
(Date:9/21/2014)... To accommodate the ever-growing customer base, Angeldress.co.uk decided ... items. Recently, the company has unveiled its 2014 ... elegant wedding gowns, Angeldress.co.uk wants to make sure that ... easy way. Its high quality vintage wedding outfits are ... to 62% off. , Online shopping is becoming more ...
Breaking Medicine News(10 mins):Health News:ExpertPages 2014 Survey Reports Expert Witness Hourly Fees Record All-Time Highs as Demand for Qualified Experts Continues to Grow 2Health News:Best Cheap Hosting USA Announces The Best Reseller Hosting Suppliers In 2014 2Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2
... Nov. 17 Shopko Stores Operating Co., LLC announced the ... www.shopko.com . Shopko partnered with SpeedFC, a ... advance the Company,s online selling initiatives. , The new online ... in apparel, home, accessories, gift cards and more. The site ...
... is one of 12 sites nationwide participating in the ... treatment for Alzheimer,s disease. The study is the first ... The experimental treatment utilizes a viral-based gene transfer ... naturally occurring protein that helps maintain nerve cell survival ...
... a new model of comprehensive health care for people ... Economics Award for Innovation in Practice Improvement from the ... Teachers of Family Medicine (STFM) and Medical Economics magazine. ... the Guided Care study and director of the Roger ...
... Hughes Medical Institute (HHMI) today committed four years, ... program between Rice University and the University of ... program -- founded with a 2006 HHMI grant ... bioengineering program and M.D. Anderson,s internationally renowned clinical ...
... ... successfully blended custom EDM machining and lights-out automation for greater speed and accuracy for ... are critical to optimized performance. , ... Tucker, GA (PRWEB) November 17, 2009 -- A proprietary new technology ...
... might help reduce heart attacks, researchers say , ... soybeans boosts levels of an important omega-3 fatty acid in ... U.S. researchers say. , They created soybeans that produce oils ... body into an omega-3 fatty acid called eicosapentaenoic acid (EPA). ...
Cached Medicine News:Health News:Shopko Announces Launch of e-Commerce Platform 2Health News:Mount Sinai researchers to test first gene therapy For Alzheimer's patients 2Health News:'Guided Care' receives Award for Innovation in Practice Improvement 2Health News:New funds for Rice, M.D. Anderson program 2Health News:Proprietary EDM Machining Technology Boosts Speed and Accuracy for Medical Components 2Health News:Biotech Soybeans Good Source of Omega-3 2
(Date:9/19/2014)... , Sept. 19, 2014  Diplomat, the nation,s largest ... David Dreyer to the Board of Directors on ... and will also serve as chair of the Audit ... years of accounting, financial, compliance and operating experience in ... has served as chief financial officer, chief operating officer ...
(Date:9/19/2014)... WOONSOCKET, R.I. , Sept. 19, 2014 Five MinuteClinic ... Memphis metropolitan area. Three clinics opened in ... earlier this month. A fourth clinic will be added in ... in Bartlett is expected to open October ... medical clinics in the United States . ...
(Date:9/19/2014)... According to market research ... Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, Surgical ... & Geography - Global Trends & Forecast to ... lyophilization market on the basis of various types, ... the market size of each of these segments ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3
... Inc., (Ticker: AVTC) ( www.autoretail.com ), is a leading ... for use in hospitals, pharmacies, medical offices and clinics. ... reduce and even eliminate prescription medicine dispensing errors.   ... of Pharmacy Practice reviewed 60 research papers that analyzed ...
... of reusable medical device cleaning validations, resulting from the U.S. ... CFR 610 , is discussed in a new management brief ... . The FDA,s proposed amendments to 21 CFR ... Register on June 21, 2011, for review and comment, ...
Cached Medicine Technology:Automated Medicine Dispensing Units Developed by AVT Can Reduce Errors 2Summary of Proposed Changes to 21 CFR 610 is Detailed in New Management Brief from Microtest Laboratories 2
... LH Ovulation Predicting Test is a qualitative ... Hormone (hLH) in human urine to predict ... by the elevation of human luteinizing hormone ... period starts, hLH has a brief, significant ...
The Pach IV is the premier product for cornea thickness measurement in conjunction with Glaucoma screening....
... The Shandon Varistain 24-4 ... stainer designed to offer simplicity ... cytology staining applications. It is ... load and continuous throughput. ...
The Shandon Linistat Linear Stainer is a compact answer to H&E frozen section protocols, with a footprint that fits on top of most cryostas to streamline workflow during frozen sectioning....
Medicine Products: