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Researchers welcome new multiple sclerosis drug
Date:1/22/2010

The Food and Drug Administration has approved the drug fampridine-SR for the treatment of multiple sclerosis. Researchers at the University of Rochester Medical Center (URMC) have been evaluating the effects of the drug in MS for more than 10 years it is the first medication shown to enhance some neurological functions in people with the disease and their efforts helped pave the way for today's action by the FDA.

"This is a good day for people who suffer from multiple sclerosis," said Andrew Goodman, M.D., chief of the URMC Multiple Sclerosis Center. "Physicians will now have a new tool at their disposal that complements existing disease modifying therapies. For some patients, this drug will be a way to improve mobility and help regain some independence in their daily lives."

Researchers at URMC helped develop the study protocols and lead the clinical trials that demonstrated consistently improved mobility timed walking speed in more than a third of patients with multiple sclerosis. This is the first instance in which a drug for multiple sclerosis was found to improve function lost as a result of the disease. Goodman and his colleagues published the results of a Phase 3 clinical trial of the drug in the journal Lancet last February.

Fampridine-SR is being developed by Acorda Therapeutics and marketed under the name Ampyra. Goodman has been a consultant and advisor to Acorda for its fampridine studies in multiple sclerosis. The company submitted a new drug application to the FDA in February 2009. An expert advisory panel recommended approval of the drug in October and that recommendation was adopted by the FDA today.

Multiple sclerosis is a disease of the central nervous system and is the most common cause of neurological disability in young adults with an estimated 2.5 million people worldwide suffering from the disease. Some of the most common symptoms are gait difficulties, muscle weakness, numbness or
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Contact: Mark Michaud
mark_michaud@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center
Source:Eurekalert

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