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Researchers use zebrafish to identify new gene linked to melanoma
Date:4/5/2011

thod for investigating malignancies, including melanoma, leukemia and sarcoma. "The melanoma model allowed us to integrate data from human genomic studies with the zebrafish. This made it possible to create thousands of transgenic animals and look for animals with more aggressive disease," Dr. Houvras says. "The zebrafish is an emerging organism in cancer biology. It has been an important organism for developmental biology and now we want to demonstrate that it has a unique set of attributes that we can use to discover new genes and treatments for patients with cancer."

Research with zebrafish has a practical side as well. The small, translucent embryos help make some processes, such as angiogenesis or genomic instability, more transparent. "For the melanoma studies, we designed and executed a study with more than 3,000 adult animals. It would have been very hard to do this kind of research with mice. I'm very excited about finding the right niche for zebrafish in cancer research. There are certain questions in cancer research that zebrafish are perfectly suited toward addressing. There is a great environment at Weill Cornell in the Departments of Surgery and Medicine for cancer research, and I am grateful that they provided me with a lab and a zebrafish facility to continue my research," Dr. Houvras says.


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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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