Navigation Links
Researchers use zebrafish to identify new gene linked to melanoma
Date:4/5/2011

NEW YORK (April 5, 2011) -- Thanks to the zebrafish, there is new hope for people with melanoma, an aggressive skin cancer that is responsible for approximately 8,700 deaths each year in the United States.

In a study that was published in the March 24th issue of the journal Nature, and featured on the cover, researchers identified SETDB1 as a new gene that promotes the growth of melanoma and may play a role in up to 70 percent of malignant melanomas.

"We hope our discovery will ultimately lead to better therapeutic strategies for patients with melanoma," says study co-first author Dr. Yariv J. Houvras, assistant professor of medicine in the Departments of Surgery, Medicine, and Cell and Developmental Biology at Weill Cornell Medical College.

Although melanoma accounts for less than 5 percent of skin cancer cases, it causes a large majority of skin cancer deaths. The American Cancer Society estimates that about 68,000 were diagnosed in the United States last year -- 39,000 in men and 29,000 in women. The incidence of melanoma continues to increase at a rate faster than that of the seven most common cancers; according to the National Cancer Institute, between 1992 and 2004 the melanoma incidence increased 45 percent.

The report in Nature originated in the laboratory of Dr. Leonard Zon, director of the Stem Cell Program at Children's Hospital Boston, where Dr. Houvras worked prior to joining Weill Cornell earlier this year. Dr. Houvras and colleagues created "MiniCoopR," a transposon-based vector to deliver candidate human test genes into a specially engineered strain of zebrafish that harbors a mutated BRAF gene. The researchers screened more than 3,000 zebrafish and found one gene that dramatically accelerated melanoma formation: SETDB1, which encodes a histone methyltransferase enzyme. Fish melanomas with elevated levels of SETDB1 are highly invasive and have a set of deregulated genes that are present in human
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... (PRWEB) December 22, 2014 Explorys, the ... additions to its leadership team: Greg Yarrington as Vice ... Engineering, and Patrick Wells as Vice President of Solutions. ... add 80 new jobs in 2015 to support client ... of its platform-as-a-service offerings, and growth of its partner ...
(Date:12/22/2014)... 22, 2014 In recognition of Veteran’s ... to Hero Reward, a local organization that provides services ... , Located on a couple hundred acres in ... offers lodging, world class fishing, hunting, hiking, horseback riding, ... founded several years ago to support U.S. Service men ...
(Date:12/22/2014)... New York NY (PRWEB) December 22, 2014 ... reports that a federal panel of judges has granted ... lawsuits in the U.S. District Court, Eastern District ... (JPML) issued an order on December 12 to transfer ... actions–pending in 22 districts to the Louisiana court for ...
(Date:12/22/2014)... 2014 Luxury Linen purveyor Peacock Alley ... Dallas to provide logistics and support for one of ... has a long history of giving back to the community ... this year's Toy Drive were Whataburger® and 99.5 The Wolf. ... the holidays. Providing gifts to children who would otherwise not ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 NAPW ... 2014 Professional Woman of the Year. She is recognized ... the largest, most recognized networking organization of professional women ... the National Association of Professional Women is a vibrant ... Local Chapters. , Ms. Kreider is passionate and committed ...
Breaking Medicine News(10 mins):Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:National Association of Professional Women Announces Cheryl A. Kreider, President / CEO of Kreider Health Solutions, LLC, a 2014 Professional Woman of the Year 2
... of in-hospital care by various physician types, findings show that ... to patients. , Study results are reported in the ... Medicine. , Findings show that compared to general internists, ... shortened by 12 percent, or nearly half a day, and ...
... Laboratories,Inc. (Nasdaq: IDXX ), announced today that it ... W. Ayers, Chairman,President and CEO, is scheduled to make ... at 8:00 a.m. (PT), at the Westin St. Francis ... webcast of,the presentation through a link on the home ...
... Who Are Becoming COMPLAINT,FREE, KANSAS CITY, Mo., Dec. ... exploded into a worldwide phenomenon and become,a popular New ... their health, relationships and careers are improving as a ... a very simple idea," said Complaint Free World founder ...
... Dec. 19 Speaker Nancy Pelosi,issued the following statement ... and SCHIP Extension Act. The bill, which extends SCHIP,through ... that no,children currently enrolled will be dropped from their ... signature into law:, "While President Bush and a ...
... introduce NutreStore(TM) in spring 2008, TORRANCE, ... a,Torrance, California based pharmaceutical company, announced today ... agreement with Cato BioVentures of,Research Triangle Park, ... brand L-Glutamine. Under this agreement, Emmaus will,commercialize ...
... 19 In 1991, Kharma Amos,dressed up as ... in Tulsa, OK., (Photo: http://www.newscom.com/cgi-bin/prnh/20071219/DC10343-a , ... year, 16-year-old Joshua Love began volunteering for lesbian,gay, ... Santa,Fe, NM. He wanted to combat homophobia and ...
Cached Medicine News:Health News:Benefits of hospitalist care confirmed in new study 2Health News:A 'Happy New You' in the New Year 2Health News:Emmaus Medical, Inc. Enters Into Sub-License Agreement for Treatment of Short Bowel Syndrome 2Health News:Emmaus Medical, Inc. Enters Into Sub-License Agreement for Treatment of Short Bowel Syndrome 3Health News:A New Year, A New Opportunity: Metropolitan Community Church Leaders Urge Faith Leaders to Address HIV and Crystal Meth Use Among LGBT Youth 2Health News:A New Year, A New Opportunity: Metropolitan Community Church Leaders Urge Faith Leaders to Address HIV and Crystal Meth Use Among LGBT Youth 3
(Date:12/19/2014)... , Dec. 19, 2014  Monarch America Inc. (OTCQB: ... Corp.) is pleased to provide this review of the ... in 2015. "Over this past year, we ... I am extremely proud to say that Monarch America ... than it has ever been," stated Eric Hagen ...
(Date:12/19/2014)... 18, 2014 Somewhere between dropping five pounds ... forgotten. But Audicus , a next-generation hearing aids ... new year. Hearing loss is the third ... though it is often unaddressed. Forty-eight million Americans have ... hearing aid, mainly due to price. Hearing aids traditionally ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... the United States will increase to a ... be primarily driven by expansion in the large direct ... devices will be increasingly adopted due to the advantages ... Other key findings from Decision Resources Group,s coverage ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Audicus Will Help People Resolve to Hear Better in 2015 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3
... Neb., Dec. 29, 2010 Transgenomic, Inc. (OTC Bulletin ... has closed the acquisition of Clinical Data, Inc.,s (Nasdaq: ... price of $15.5 million.  In addition, the company has ... LLC, a leading life sciences investment firm, to fund ...
... MeridianRx is pleased to welcome Health Plan of Michigan ... MeridianRx will handle processing and payment of prescription ... (HPM). HPM is the state,s largest managed Medicaid plan, serving ... Benefit Manager (PBM) program, creates savings for clients by using ...
Cached Medicine Technology:Transgenomic Announces Closing of the Acquisition of Clinical Data's Diagnostic Business and the Closing of a $6 Million Financing 2Transgenomic Announces Closing of the Acquisition of Clinical Data's Diagnostic Business and the Closing of a $6 Million Financing 3Transgenomic Announces Closing of the Acquisition of Clinical Data's Diagnostic Business and the Closing of a $6 Million Financing 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: