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Researchers use sugar to halt esophageal cancer in its tracks
Date:1/15/2012

Mahalthey found that there were different sugar molecules present on the surface of the pre-cancerous cells. This technology uses sugar binding proteins, known as lectins, to identify changes in sugars and pinpointed carbohydrate binding wheat germ proteins as a potential diagnostic. When the wheat germ proteins, attached to a fluorescent tag that glows under a specific type of light, were sprayed onto tissue samples, it showed decreased binding in areas of dysplasia, and these cells were clearly marked compared with the glowing green background.

"The rise in cases of oesophageal cancer both in the UK and throughout the Western world means that it is increasingly important to find ways of detecting it as early as possible," Fitzgerald said. "Our work has many potential benefits for those with Barrett's esophagus who have an increased risk of developing esophageal cancer."

"We have demonstrated that binding of a wheat germ protein, which is cheap and non-toxic, can identify differences in surface sugars on pre-cancerous cells," she added. "And when coupled with fluorescence imaging using an endoscopic camera, this technique offers a promising new way of finding and then treating patients with the highest risk of developing esophageal cancer, at the earliest stage."


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Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

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