Navigation Links
Researchers use new molecular inhibitors to successfully hit difficult cancer target
Date:2/5/2013

CINCINNATI Early laboratory tests are the first to successfully use an experimental molecular therapy to block a hard-to-target part of a protein complex linked to several types of invasive cancer.

Scientists report online Feb. 4 in PNAS Early Edition the rational design of a small-molecule inhibitor they call Y16. In laboratory tests, the inhibitor helped stop the spread of cultured human breast cancer cells, especially when it was used with another compound known as Rhosin/G04.

The study was conducted by researchers in the Cancer and Blood Diseases Institute at Cincinnati Children's Hospital Medical Center, who developed both of the small-molecule inhibitors.

"We are using the findings from this study to refine our compounds and test them on mouse models of Acute Myeloid Leukemia and certain metastatic tumors especially breast cancer, where the target pathway of this lead inhibitor is hyperactive," said Yi Zheng, lead investigator and director of Experimental Hematology/Cancer Biology at Cincinnati Children's.

Y16 and Rhosin/G04 appear to successfully target G-protein mediated Rho guanine nucleotide exchange factors (GEFs), which are part of the Rho GTPase complex of cell signaling proteins. Specifically, the compounds inhibit cell signaling that activates part of the protein complex involving a well-known enzyme, RhoA.

Under normal circumstances, the Rho GTPase complex helps maintain a delicate biological balance in regulating cell structure and function, including proliferation and movement. When the complex becomes dysfunctional, it can cause the hyper-activation of invasive cell growth and cancer.

Small molecule inhibitors are tiny organic compounds that attach to proteins to keep them from binding with other proteins. The intent is to block the activation of harmful biological pathways such as aberrant Rho activity that fuel disease. Used in a dose dependent manner, these compounds can
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers discover mutations linked to relapse of childhood leukemia
2. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
3. Leading researchers warn of brain drain as scientists struggle to find funding
4. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
5. Researchers help confirm value of flow-diverting device for most challenging aneurysms
6. Researchers improve medical units to reduce nursing fatigue, cut costs
7. Researchers find gene that turns up effect of chemotherapy
8. Israeli researchers to participate in European Commission flagship
9. Tumor cells engineer acidity to drive cell invasion, Moffitt Cancer Center researchers say
10. Researchers say its time to treat anemia seriously
11. Rush researchers studying stem cell therapy to repair damaged knee cartilage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... (PRWEB) November 27, 2014 This ... on Global Insulin industry. For an overview analysis, ... classification, application, industry chain structure, industry overview, policy ... global Insulin industry covers information on policy, ... product cost structure and much more. ...
(Date:11/27/2014)... GA (PRWEB) November 27, 2014 "The uglier, ... whole month of December is full of laughter as we ... Wilson won by making a sweater from scratch. " It ... Christmas tree, and if that weren't ridiculous enough, the Christmas ... top. , For those interested in participating this year, ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 VeloReality Inc. ... six new Real Life Videos (RLVs) of world-famous velo courses ... Trainer, as well as other popular indoor velo trainers. Two ... available worldwide before the end of November -- in ... the total number of rides in the VeloReality collection to ...
(Date:11/26/2014)... 2014 Healthpointe is proud to provide ... , and it will be led by a renowned ... field of Occupational Medicine and utilizes the latest medical ... delivers quality care for employers and their employees, and ... , As an Occupational Medicine physician, Dr. ...
(Date:11/26/2014)... Day is traditionally the day following Christmas Day, when ... "Christmas box", from their bosses or employers. (Source from ... Day, some people may worry about the boxing day ... it has recently announced its “ Tbdress Boxing Day ... customers. Then people can buy cheap pants, dresses, shoes ...
Breaking Medicine News(10 mins):Health News:Insulin Industry Analysis (Supply, Consumption) for China, America, Korea, France & Japan Research Now at ReportsnReports 2Health News:Insulin Industry Analysis (Supply, Consumption) for China, America, Korea, France & Japan Research Now at ReportsnReports 3Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 3Health News:Winter 2015 Weather Forecast Is Warm and Dry For VeloReality Riders With New RLV Offering 2Health News:Winter 2015 Weather Forecast Is Warm and Dry For VeloReality Riders With New RLV Offering 3Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 2Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 3Health News:Tbdress.com: Best Boxing Day Sales For Ladies Worldwide 2
... new robotic surgery technique appears promising for the removal ... report in the December issue of Archives of OtolaryngologyHead ... Typically, surgeons trying to remove tonsils of patients with ... area, according to background information in the article. If ...
... Erline Perkins McGriff Professor and dean of the College of ... College board of,trustees., A 1976 graduate of Skidmore, she ... holds fellow status in the New York Academy of Medicine.,Fulmer ... Gerontological,Society of America, and also the first nurse to be ...
... New Series "Celebrity Rehab with Dr. ... ..., Maybe Baby" and "Scott Baio is 46 ... and Pregnant" Kick Off The New ... ... 2008 with a full,slate of new premieres and returning series. For the first time VH1 ...
... dietician, certified personal trainer, marathoner, and wellness enthusiast will design individualized ... better, longer, healthier and younger ... ... be, better nutrition for active,lifestyles available exclusively at Target stores, announces ...
... 17 Diagnostic Health Corporation,(DHC) today announced that ... its home office operations to 22 Inverness Center ... imaging company created,by HealthSouth,s sale of its diagnostic ... most of DHC,s 1,000 employees work in its ...
... - Aspreva Pharmaceuticals,Corporation (NASDAQ: ASPV ; TSX: ... approved the proposed acquisition of,Aspreva by Galenica Group ... price of US$26.00 per share in cash. At ... transaction was approved,by over 99% of the votes ...
Cached Medicine News:Health News:Robotic device appears useful for surgical removal of cancer involving the tonsils 2Health News:Terry Thomas Fulmer, Dean of NYU's College of Nursing, Elected to Skidmore College Board 2Health News:VH1 Set to Continue Its Record-Breaking Pace Into 2008 with Brand New Premieres and Returning Series 2Health News:VH1 Set to Continue Its Record-Breaking Pace Into 2008 with Brand New Premieres and Returning Series 3Health News:VH1 Set to Continue Its Record-Breaking Pace Into 2008 with Brand New Premieres and Returning Series 4Health News:be(R) is Making Health Simple With Complimentary, Expert Online Diet, Nutrition and Exercise Advice 2Health News:Diagnostic Health Corporation Announces New Home Office Location 2Health News:Aspreva obtains shareholder approval for acquisition by Galenica 2Health News:Aspreva obtains shareholder approval for acquisition by Galenica 3Health News:Aspreva obtains shareholder approval for acquisition by Galenica 4
(Date:11/26/2014)... , Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... circulatory support therapies to save, support and restore failing ... upcoming investor conferences. On Tuesday, December 2, ... Annual Piper Jaffray Healthcare Conference.  D. Keith Grossman ... update on the company beginning at 11:30 a.m., Eastern ...
(Date:11/26/2014)... 2014  Genomic Health, Inc. (Nasdaq: GHDX ) ... Executive Officer and President, will participate in the 26 ... New York Palace Hotel in New York ... Eastern Time (ET). To access the live ... to the  Investor Relations  section of the company,s web ...
(Date:11/26/2014)... , November 26, 2014 Investor-Edge ... VVUS ), Horizon Pharma PLC (NASDAQ: ... and Johnson (NYSE: JNJ ), and Theravance Inc. ... companies can be accessed at: http://investor-edge.com/register . ... 4,758.25, up 0.07%, the Dow Jones Industrial Average edged 0.02% ...
Breaking Medicine Technology:Thoratec Announces Presentations At Investor Conferences For December 2014 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... to Receive Treatment Using Gated... -- BELLINZONA, Switzerland, Aug. 31 ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in data.results) ...
... TAINAN, Taiwan, Aug. 31 /PRNewswire-Asia/ -- ... ... var shortURL = ""; ... we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; ...
Cached Medicine Technology:Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 2Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 3Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 4Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 5Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 6Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 7Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems 8ScinoPharm to Invest in Tanvex Biologics 2ScinoPharm to Invest in Tanvex Biologics 3ScinoPharm to Invest in Tanvex Biologics 4ScinoPharm to Invest in Tanvex Biologics 5ScinoPharm to Invest in Tanvex Biologics 6
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
Medicine Products: