Navigation Links
Researchers use light to measure cancer cells' response to treatment
Date:12/20/2011

WASHINGTON, Dec. 20Many cancer therapies target specific proteins that proliferate on the outside of some cancer cells, but the therapies are imperfect and the cancer does not always respond. Since it is beneficial for doctors to know as soon as possible how a cancer is affected by treatment, researchers from Vanderbilt University are striving to design tests that assess treatment response rapidly, accurately, and cost-effectively. The team has demonstrated a new way to optically test cultured cancer cells' response to a particular cancer drug. The results appear in the December issue of the Optical Society's (OSA (http://www.osa.org)) open-access journal Biomedical Optics Express (http://www.opticsinfobase.org/boe).

Certain cancer cells display a higher-than-normal number of proteins called human epidermal growth factor receptor 2 (HER2). In healthy cells, HER2 helps mediate cell growth, but overexpression of HER2 can mark one of the most aggressive forms of breast cancer. Drugs that bind to and block growth factor receptors have been shown to prolong life in some cancer patients, but about 30 percent of HER2 overexpressing tumors do not respond to the drug. Tests to identify these non-responding tumors early on would help doctors make important treatment decisions that could improve patient outcomes.

To design such a test, the Vanderbilt team took advantage of the fact that some cancer cells preferentially use a different metabolic pathway when compared to normal cells. The researchers visualized the relative use of the different pathways by shining the cells with frequencies of light that caused two different metabolic molecules to naturally fluoresce. They then calculated a ratio between the two levels of fluorescence, called an optical redox ratio. The team found that, of the different cell lines they tested, HER2 overexpressing cells had the highest optical redox ratio. They also found that when HER2 cancer cells were treated with an HER2-blocking drug, the ratio decreased. This decrease, however, was not observed in cancer cells that were resistant to the drug. The findings lay the groundwork for future in vivo studies and hold the promise that real-time tumor response to treatment might be measured optically.


'/>"/>
Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

Related medicine news :

1. MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain
2. MU researchers find pet kidney injuries are similar to human kidney injuries
3. UC Irvine researchers urge caution when buying noisy toys
4. Ohio State researchers discover hereditary predisposition of melanoma of the eye
5. Researchers investigate link between autoimmune diseases and wounds that dont heal
6. Researchers describe a new genetic program that converts static cells into mobile invasive cells
7. UIC researchers discover how cells limit inflammation in lung injury
8. Researchers identify phthalates in numeruous medicines and supplements
9. BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
10. Jefferson researchers mirror human response to bacterial infection and resolution in mice
11. Leibniz Prize 2012 to honor 11 outstanding researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Shamanic healer and teacher ... Healing and Spiritual Awakening, proudly presents her Sacred Peru retreat with world ... and spiritual journey during the Summer Solstice will also be her final international ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... are now offering treatments for sleep apnea and TMJ at their office. TMJ, ... apnea , specifically the obstructive type, is increasingly being treated at dental offices ...
(Date:3/24/2017)... ... ... who like to educate themselves on current issues and who enjoy gaining knowledge on ... to appreciate and love the "Informed" series, hosted by Rob Lowe. A new ... the world. , Running for charity has become a multi-million dollar enterprise ...
(Date:3/24/2017)... ... 2017 , ... Judy Buchanan, co-owner of Serenity Natural Health ... says, “I am passionate about sharing Reiki as a holistic, complementary therapy with ... time.” , A Certified Medical Reiki™ Master trained by Raven Keys Medical Reiki™ ...
(Date:3/24/2017)... , ... March 24, 2017 , ... “Vintage and Harvest ... retired minister and college Bible teacher residing in North Carolina with his wife, Anna ... have blessed them with six grandchildren. David is also the author of “Shadow and ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , Mar 24, 2017 The Board of ... company,s Annual Report 2016 including the complete 2016 Annual Accounts ... available on Nordic Nanovector,s website in the section Investor Relations/Reports ... ... enquiries: Tone Kvåle, Chief Financial Officer Cell: +47-91-51-95-76 Email: ...
(Date:3/23/2017)... Ala. , March 23, 2017 Mosaic Life Care, based in ... the patient registration process across its network of 58 clinics, located in 22 cities, ... seeking new and innovative ways to improve the delivery of health care to its ... Continue Reading ... Mosaic Life Care St. Joseph Medical ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market: Analysis By Procedure, Replacement Procedure By Technique, Repair Procedure By ... ... Valve Devices Market is forecasted to grow at a CAGR of ... devices is driven by rising aging population, growth in population with ...
Breaking Medicine Technology: