Navigation Links
Researchers use light to measure cancer cells' response to treatment
Date:12/20/2011

WASHINGTON, Dec. 20Many cancer therapies target specific proteins that proliferate on the outside of some cancer cells, but the therapies are imperfect and the cancer does not always respond. Since it is beneficial for doctors to know as soon as possible how a cancer is affected by treatment, researchers from Vanderbilt University are striving to design tests that assess treatment response rapidly, accurately, and cost-effectively. The team has demonstrated a new way to optically test cultured cancer cells' response to a particular cancer drug. The results appear in the December issue of the Optical Society's (OSA (http://www.osa.org)) open-access journal Biomedical Optics Express (http://www.opticsinfobase.org/boe).

Certain cancer cells display a higher-than-normal number of proteins called human epidermal growth factor receptor 2 (HER2). In healthy cells, HER2 helps mediate cell growth, but overexpression of HER2 can mark one of the most aggressive forms of breast cancer. Drugs that bind to and block growth factor receptors have been shown to prolong life in some cancer patients, but about 30 percent of HER2 overexpressing tumors do not respond to the drug. Tests to identify these non-responding tumors early on would help doctors make important treatment decisions that could improve patient outcomes.

To design such a test, the Vanderbilt team took advantage of the fact that some cancer cells preferentially use a different metabolic pathway when compared to normal cells. The researchers visualized the relative use of the different pathways by shining the cells with frequencies of light that caused two different metabolic molecules to naturally fluoresce. They then calculated a ratio between the two levels of fluorescence, called an optical redox ratio. The team found that, of the different cell lines they tested, HER2 overexpressing cells had the highest optical redox ratio. They also found that when HER2 cancer cells were treated with an HER2-blocking drug, the ratio decreased. This decrease, however, was not observed in cancer cells that were resistant to the drug. The findings lay the groundwork for future in vivo studies and hold the promise that real-time tumor response to treatment might be measured optically.


'/>"/>
Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

Related medicine news :

1. MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain
2. MU researchers find pet kidney injuries are similar to human kidney injuries
3. UC Irvine researchers urge caution when buying noisy toys
4. Ohio State researchers discover hereditary predisposition of melanoma of the eye
5. Researchers investigate link between autoimmune diseases and wounds that dont heal
6. Researchers describe a new genetic program that converts static cells into mobile invasive cells
7. UIC researchers discover how cells limit inflammation in lung injury
8. Researchers identify phthalates in numeruous medicines and supplements
9. BUSM researchers find link between pulmonary inflammation, diesel exhaust, house dust
10. Jefferson researchers mirror human response to bacterial infection and resolution in mice
11. Leibniz Prize 2012 to honor 11 outstanding researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... or dementia. However, many long-term care insurance companies have a waiver for care if ... the 90-day elimination period, when the family pays for care, is often waived, so ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... Chapel, FL (PRWEB) , ... October 12, 2017 , ... ... is holding a treadmill relay – Miles by Moonlight to raise money for the ... donating $300 or more. , Teams will work together to keep their treadmills ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
Breaking Medicine Technology: