Navigation Links
Researchers use immunocytochemistry to determine ALK status
Date:7/1/2013

DENVER Personalized medicine in lung cancer relies on the identification and characterization of cancer biomarkers and the availability of accurate detection systems and therapies for those biomarkers. The standard procedure for detection of predictive anaplastic lymphoma kinase (ALK)-rearrangements is fluorescence in situ hybridization (FISH), but FISH is both expensive and often challenging to interpret. Lung cancer is often diagnosed by cytology necessitating predictive molecular marker analyses on cytological specimens.

Now research published in the August issue of the Journal of Thoracic Oncology (JTO), says ALK immunocytochemistry is highly accurate for detecting ALK-rearranged non-small cell lung cancer (NSCLC) on cytological specimens.

Researchers retrospectively analyzed 41 specimens with available ALK FISH results with the 5A4 monoclonal antibody on a fully automated slide stained. The study population was enriched for consecutive ALK FISH-positive NSCLCs. Eighteen consecutive ALK FISH-negative NSCLCs with EGFR and KRAS wild-type were included as negative controls. Because ALK rearrangements are practically mutually exclusive to other known driver mutations, nine consecutive NSCLCs with EGFR mutations were also analyzed by ALK FISH and included as negative controls. The sensitivity, specificity and positive and negative predictive values for ALK immunocytochemistry compared to ALK FISH were 93.3 percent, 96 percent, 93.3 percent and 96 percent, respectively.

The researchers conclude that, cytological NSCLC specimens are well suited for ALK rearrangement testing. ALK ICC with the 5A4 mAb is feasible and highly accurate for the detection of ALK-rearranged NSCLC on conventional cytological specimens and cellblock preparations and can be used for prescreening NSCLCs.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers find 2 new methods to determine ALK status
2. CWRU researchers trace inner-city womens health issues to childhood traumas
3. Penn Medicine researchers discover link between fear and sound perception
4. UCI researchers awarded $2.27 million to create novel diabetes treatments
5. MS researchers determine that brain reserve independently protects against cognitive decline in MS
6. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
7. PhD Thesis Writing Expands the Scope of its Services for Doctoral Researchers
8. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
9. Researchers identify master coordinator for aortic rupture
10. Fate of the heart: Researchers track cellular events leading to cardiac regeneration
11. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Bradley, Illinois (PRWEB) January 22, 2015 Deer ... -- will host a Valentine’s Day Happy Hour from 3 p.m. ... located at 12500 Regency Parkway in Huntley, Illinois, serves adults with ... Happy Hour event will include Valentine's Day treats, games and sweetheart-themed ...
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... 2015 Angelweddingdress is a famous wedding dress ... customers to follow it on Facebook, Twitter, and Pinterest. The ... gift. Angelweddingdress draws a lottery every week. , Moreover, the ... 28, 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A new ... of experience and person-centeredness in the long-term care environment ... action across the continuum. The paper, “The Power of ... engages perspectives and practices of the patient, resident and ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved ... upcoming 32nd Annual Miami Breast Cancer Conference ... LLC (PER®) , shares that “a fast-growing, virulent” cancer ... she had not followed up her clean mammogram with ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... people are well aware of Kawasaki as a motorcycle rather ... when doctors informed that his 9 year old daughter, Utkarsha ... named so as it is prevalent among Korean and Japanese ... knew that Kawasaki was a disease,' remarked Dinesh Ghai. ...
... new study in Australia has found that babies born to ... poor birth weight and lower APGAR scores and are more ... ,These women have a higher number of previous pregnancies, smoke ... according to the study in the April issue of Alcoholism: ...
... It has been proposed by Caboolture Hospital management to offer ... emergency department //. In response to the above proposal, ... unconscionable. ,The popular Aspen Medical Group had advertised ... medicine department, with an attractive a remuneration package of $500,000-plus. ...
... was an 18-month-old baby who succumbed to HIV/AIDS infection that ... village mourns her death//. ,The infection was acquired ... five months ago . ,Rashmi was suffering from ... taken to the hospital fro blood transfusion. She returned home ...
... to be a heroin user.Pink started using drugs at the age ... reported ananova.com. , ,"Heroin is a horrible thing. I have ... is not pretty. I was never that much into it to ... drugs - you name it, I took it. I buried three ...
... to run all educational and charitable institutions operated in ... whose head was // detained in connection with a ... schools, hospitals and orphanages in the state. ... registration of the society and arrested its chief Samuel ...
Cached Medicine News:Health News:Low Awareness Of Kawasaki Disease In Capital: Parents Form Support Group 2Health News:Use Of Alcohol During Pregnancy Affects Newborns 2Health News:Rajasthan Plans To Run Christian Institutions 2
(Date:1/23/2015)... Biotherapeutics, Inc. (NASDAQ: NWBO )("NW Bio"), a U.S. ... inoperable solid tumor cancers, announced today that CEO Linda ... Phacilitate Immunotherapy Forum in Washington D.C. ... on January 26 at 10:30 a.m. EST at the Grand ...
(Date:1/23/2015)... Jan. 23, 2015  Pete Rose, baseball,s all-time hits leader, is ... pain reliever Myoflex, Ducere Pharma has announced. "Pete,s ... excited to have him on board with Myoflex," said Ducere ... a legendary player who is known across all generations. The ...
(Date:1/23/2015)... Blood America, Inc. ( www.cordblood-america.com ) (OTC Bulletin Board: ... Proxy Statement, Schedule 14A, with the U.S. Securities & Exchange ... shareholders detailing why a "YES" vote to increase the number ... As we reflect upon the 2014 fiscal year that ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Pete Rose bets on Myoflex to relieve aches and pains 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4
... New Zealand, Aug. 24 Rex Bionics Ltd., the ... walk, announced formation of an International Advisory Board that ... Williams .  Also named to the new board were ... of Virginia, Charlottesville, Va., and Frank Gardner, the BBC,s ...
... Bulletin Board: SNDZ ), announced today that it ... key brokers and funds.  The purpose of these meetings will ... facilitate funding for Sunridge to execute its business plan for ... this project," states G. Richard Smith, CEO of Sunridge.  "We ...
Cached Medicine Technology:Award-Winning U.S. Talk Show Host Montel Williams Joins Rex Bionics New International Advisory Board 2
BD Beaver DeBakey blade, 5 mm cutting width, sterile....
RM-1970 Mucotome ergonomic design with E-Type coupling, designed for mucosal repair surgery....
RM-1900 Dermatome developed for reconstructive plastic surgery with E-Type coupling. Dermatome with 50 mm cutting width....
... Model C Dermatome - reaching a new evolutionary ... forward to operate in the pulse mode, or ... the entire instrument and hose assembly is autoclavable ... in 2-, 3-, or 4-inch widths. Simply select ...
Medicine Products: