Navigation Links
Researchers use computational models to study fear
Date:9/30/2009

COLUMBIA, Mo. The brain is a complex system made of billions of neurons and thousands of connections that relate to every human feeling, including one of the strongest emotions, fear. Most neurological fear studies have been rooted in fear-conditioning experiments. Now, University of Missouri researchers have started using computational models of the brain, making it easier to study the brain's connections. Guoshi Li, an electrical and computer engineering doctoral student, has discovered new evidence on how the brain reacts to fear, including important findings that could help victims of post-traumatic stress disorder (PTSD).

"Computational models make it much easier to study the brain because they can effectively integrate different types of information related to a problem into a computational framework and analyze possible neural mechanisms from a systems perspective. We simulate activity and test a variety of "what if" scenarios without having to use human subjects in a rapid and inexpensive way," Li said.

From previous experiments, scientists have found that fear can subside when overcome with fear extinction memory, but it is not permanently lost. Fear extinction is a process in which a conditioned response to a stimulant that produces fear gradually diminishes over time as subjects, such as rats in auditory fear experiments, learn to disassociate a response from a stimulus. One theory has concluded that fear extinction memory deletes fear memory, and another concluded that fear memory is not lost, but is inhibited by extinction memory as fear can recover with the passage of time after extinction.

"Fear extinction memory is not well understood, and our computational model can capture the neuron response well in rat during auditory fear conditioning with a mixture of mathematics and biophysical data," said Li. "Our main contribution is that our model predicts that fear memory is only partially erased by extinction, and inhib
'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers develop an integrated treatment for veterans with chronic pain and posttraumatic stress
2. UT Houston, Jamaica researchers launch autism study
3. Paul Marks prize recognizes 3 young cancer researchers
4. Van Andel Institute researchers find gene that could lead to new therapies for bone marrow disease
5. Mayo researchers find few side effects from radiation treatment given after prostate cancer surgery
6. U of T researchers create microchip that can detect type and severity of cancer
7. Researchers believe hormone therapy should not be stopped prior to mammograms
8. McMaster researchers discover a new antibacterial lead
9. BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
10. UCI researchers create new strategy for highly selective chemotherapy delivery
11. UCI researchers create new strategy for highly-selective chemotherapy delivery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... New Rochelle, NY, April 17, 2014U.S. military personnel ... "blast plus impact" concussive traumatic brain injury (TBI) ... were evacuated for other medical reasons. Differences in ... and depression 6-12 months after injury are reported ... , a peer-reviewed journal from Mary Ann Liebert, ...
(Date:4/17/2014)... older Americans suffer from depression, often brought on by ... a project that followed the lives of thousands ... that Internet use among the elderly can reduce the ... "That,s a very strong effect," said Shelia Cotten, a ... media who led the project. "And it all has ...
(Date:4/17/2014)... 2014-- Colic affects about one in five infants in ... visits during the first several months after birth. Research ... showing promise; however, the April 1, 2014 issue of ... reported on a study, "Probiotics and Infant Colic," concluding ... for infant colic did not reduce crying ...
(Date:4/17/2014)... School of Medicine (BUSM) have discovered that the ... experimental model. The findings, reported in the ... may lead to more effective treatments for alcoholism. ... the leading causes of illness and death in ... by limiting the productivity of workers and necessitating ...
Breaking Medicine News(10 mins):Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2
... convene for one week in Adelaide from Sunday 1 ... Medical Students Association (AMSA). ,The largest ... event brings students from each of Australias 17 medical ... week of activities. ,The Convention will feature ...
... toxicology reports have confirmed that she was drunk and had ... in Beverly Hills on Memorial Day weekend. ... the Mean Girls star had cocaine and nearly twice the ... arrested last month and cited for driving under the influence. ...
... Health Organization (WHO) has said that the risk of developing ... hours or more. ,In a research study of ... absolute risk of developing VTE, if seated and immobile for ... in 6000. ,According to the study, the two ...
... understand the mechanism by which cells grow and cancer ... Listeria Monocytogenes in their project. ,The research ... Keith Ireton, had recently found that a Listeria protein ... receptor known as Met, which has been implicated in ...
... the experts are happy about the significant improvement in ... discovery of a new virus carried by bats ... ,Health and veterinary experts have singled out Indonesia, ... bird flu contagion is particularly worrisome. ,FAO's ...
... provider in Andhra Pradesh, Thursday announced that it would ... to set up new state-of-the-art hospitals in six states. ... 10 years, plans to open new hospitals in Madhya ... ,The expansion plans were announced by eminent cardiologist and ...
Cached Medicine News:Health News:Thrombosis Risk in Travel Lasting Over Four Hours is Higher: WHO 2Health News:Study of Bacterial Pathogen may Give Insight to Cancer Development 2Health News:Avian Flu Seen in Others Birds too 2Health News:Avian Flu Seen in Others Birds too 3
(Date:1/15/2014)...  Novation, the leading health care supply chain expertise, analytics ... (VAR) national contracts that expand its portfolio to provide ... costs. These include manufacturer product and service agreements, as ... ongoing IT consulting support. New Novation ...
(Date:1/15/2014)... plc (LSE: SHP, NASDAQ: SHPG ) announces that it ... the announced tender offer for all of the outstanding shares of ... the waiver, the transaction is no longer conditional on OFT approval, ... 2014 following the currently scheduled expiration time, subject to the satisfaction ...
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2
... 8, 2011   SynCardia Systems, Inc. ( www.syncardia.com ), ... Canada and CE (Europe) approved Total Artificial Heart, has ... " America,s Most Promising Companies ." The list features ... management teams, notable customers , strategic partners and ...
... Biotechnology Corporation (OTCBB: GNBT.OB) today announced that positive interim ... a novel Ii-Key Hybrid-based HER-2/neu Peptide Vaccine (AE37) in ... 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium (SABCS) ... developed by its wholly-owned subsidiary, Antigen Express, Inc. ...
Cached Medicine Technology:Forbes Names SynCardia One of "America's Most Promising Companies" 2Forbes Names SynCardia One of "America's Most Promising Companies" 3Breast Cancer Vaccine Reduces Cancer Recurrence in Women: Interim Results From Phase 2 Clinical Trial Trend Toward AE37 Vaccine Benefit; Results Presented at SABCS 2Breast Cancer Vaccine Reduces Cancer Recurrence in Women: Interim Results From Phase 2 Clinical Trial Trend Toward AE37 Vaccine Benefit; Results Presented at SABCS 3Breast Cancer Vaccine Reduces Cancer Recurrence in Women: Interim Results From Phase 2 Clinical Trial Trend Toward AE37 Vaccine Benefit; Results Presented at SABCS 4Breast Cancer Vaccine Reduces Cancer Recurrence in Women: Interim Results From Phase 2 Clinical Trial Trend Toward AE37 Vaccine Benefit; Results Presented at SABCS 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: