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Researchers use cell 'profiling' to detect abnormalities -- including cancer
Date:1/25/2011

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Obtaining data from live cell image sequences to use as an input in the mathematical models is not easy. For this, Coskun collaborated with Hakan Ferhatosmanoglu, an associate professor, and his then-student, Ahmet Sacan, both of computer science and engineering at Ohio State. They created open source software called CellTrack to extract data from movies of cell motion.

Given a movie of live cells under the microscope, CellTrack tracks individual cells, extracts data that can be used in the mathematical models, and provides other useful statistical information about the motion.

Huseyin Coskun acknowledged the current limits of his methodology. The researchers were able to show that their mathematical models can be applied to analyze single cell motion and obtain useful information. They were also able to hypothesize a biological explanation for very complex mechanism of cell motion based on their mathematical model outcomes. But he and his partners need many more high-resolution movies of healthy cells and cancer cells to build upon this initial work. That's why Coskun is setting up collaborations with medical researchers at Ohio State and other universities.

Coskun believes that mathematical techniques such as his are becoming more common in the biomedical sciences because they allow researchers to perform studies that would be too difficult, time-consuming or expensive in real life. He hopes his technique could be used to answer emerging questions in cell biology.


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Contact: Huseyin Coskun
coskun.5@osu.edu
614-292-5131
Ohio State University
Source:Eurekalert

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