Navigation Links
Researchers use cell 'profiling' to detect abnormalities -- including cancer
Date:1/25/2011

COLUMBUS, Ohio -- An Ohio State University mathematician and his colleagues are finding ways to tell the difference between healthy cells and abnormal cells, such as cancer cells, based on the way the cells look and move.

They are creating mathematical equations that describe the shape and motion of single cells for laboratory analysis.

Though this research is in its early stages, it represents an entirely new way of identifying cell abnormalities, including cancer. It could one day be useful in gauging future stages of a disease -- for example, by detecting whether cancer cells are aggressive and likely to spread throughout the body, or metastasize.

In a paper published online in the Bulletin of Mathematical Biology, researchers describe a mathematical model which analyzes image sequences of single, live cells to determine abnormalities manifested in their shape and behavior. A brain tumor cell was one of the cell types they analyzed in the study.

Huseyin Coskun, visiting assistant professor of mathematics at Ohio State and leader of the project, described their novel approach as a first step toward developing mathematical tools for diagnosing cell abnormalities and for giving potential prognoses.

Because the technique would allow doctors to view how cancer cells behave under different physical or chemical conditions, it could also be used to test different treatment strategies for each individual patient -- such as determining the most efficient dose of chemotherapeutic agents or radiation -- or even to test entirely new treatments.

In addition, Coskun sees his technique as a tool for also pathologists, who typically look at photographs of biopsied cells to identify cancer and judge how advanced the cancer may be.

"A pathologist can diagnose cancer, but as far as predicting the future, they don't have many tools at their disposal -- particularly if a cancer is in its early stages," Coskun said. "That's why I believe that one of the most important applications of this research is profiling cancer cells. Given a cell's motion and its morphological changes, we want to be able to determine what's happening inside the cell. If it looks like a cancer cell, and a particularly aggressive one, we would like to quantify how likely it is that the cancer cells will invade the body."

In a very basic sense, diagnosing a "sick" cell such as a cancer cell by its appearance, motion, and behavior is analogous to diagnosing a sick human, he said. "When we get sick, our behavior changes. We may stay in bed, sleep a lot -- maybe we are coughing or sneezing. These are basic symptoms that a doctor will consider to determine if we're sick. Abnormalities oftentimes manifest themselves as behavioral changes in all living organisms. Therefore, a careful analysis of and profiling the behavioral patterns of single cells could provide valuable information."

Cell motion is important for all life, he continued. White blood cells move when they attack microbes that have invaded the body. A wound heals when newly grown cells move in to close it. But something about aggressive cancer cells causes them to move from the tumor where they originated into the blood stream, where they migrate to different organs and grow out of control.

Living cells often change shape, expand, or contract, and Coskun believes that he and his colleagues can create unique "personality profiles" of cancer cells.

Coskun and his colleague, Hasan Coskun, assistant professor of mathematics at Texas A&M University-Commerce, used a branch of physics called continuum mechanics to derive equations that describe cells' appearance and behavior. They compared their model outcomes to findings from past cancer studies, which indicated that cancer cells are more deformable than normal cells.

The researchers discovered that their model results agree with those experimental findings.

Obtaining data from live cell image sequences to use as an input in the mathematical models is not easy. For this, Coskun collaborated with Hakan Ferhatosmanoglu, an associate professor, and his then-student, Ahmet Sacan, both of computer science and engineering at Ohio State. They created open source software called CellTrack to extract data from movies of cell motion.

Given a movie of live cells under the microscope, CellTrack tracks individual cells, extracts data that can be used in the mathematical models, and provides other useful statistical information about the motion.

Huseyin Coskun acknowledged the current limits of his methodology. The researchers were able to show that their mathematical models can be applied to analyze single cell motion and obtain useful information. They were also able to hypothesize a biological explanation for very complex mechanism of cell motion based on their mathematical model outcomes. But he and his partners need many more high-resolution movies of healthy cells and cancer cells to build upon this initial work. That's why Coskun is setting up collaborations with medical researchers at Ohio State and other universities.

Coskun believes that mathematical techniques such as his are becoming more common in the biomedical sciences because they allow researchers to perform studies that would be too difficult, time-consuming or expensive in real life. He hopes his technique could be used to answer emerging questions in cell biology.


'/>"/>

Contact: Huseyin Coskun
coskun.5@osu.edu
614-292-5131
Ohio State University
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Looking for a last-minute Valentine’s ... the tips of your toes. Foot massage, whether administered by a professional masseuse or ... relaxation. The American Board of Multiple Specialties in Podiatry (ABMSP) has taken ...
(Date:2/5/2016)... Rafael, CA (PRWEB) , ... February 05, 2016 , ... ... with ChildLight Yoga Studio in Dover, NH to direct high-performance kids yoga training. ChildLight ... New Hampshire’s seacoast, just one hour from Boston. , ChildLight Yoga Studio founder Lisa ...
(Date:2/5/2016)... ... 05, 2016 , ... Give To Cure today announced that it ... to Give To Cure’s campaign that is crowdfunding clinical trials to help find cures ... payments through a smart device. In 2015 alone, Venmo processed $7.5 billion in transactions ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Dr. Justin ... announce their 2nd Annual No Cost Dental Day to individuals in need. The event ... purpose of this No Cost Dental Day is to provide dental care to community ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... In sleep, ... form as a dream. A hallmark feature of patients with eating disorders is significant ... The eating disorder behaviors and obsessions are regarded as maladaptive means for coping with ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... 4, 2016  Montoya Love is recognized by Continental ... of Pharmaceuticals. Montoya is the Regulatory Systems Operations Manager ... Manufacturing and selling a broad ... provides healthcare institutions, clinical laboratories and life science ... across the globe. ...
(Date:2/4/2016)... 2016 Frontier Pharma: Chronic Obstructive Pulmonary ... Chronic Obstructive Pulmonary Disease (COPD) ... of the airways and lungs. Persistent breathing difficulties ... disease one of the leading causes of morbidity ... world. COPD is linked to cumulative exposure to ...
Breaking Medicine Technology: