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Researchers unzip MRSA and discover route for vaccine
Date:1/16/2011

ated exactly how the antibody works. Since MRSA is inclined to grow rapidly, as single cells, they sought an antigen that forced the bacteria cells to clump. Electron microscopy images of the bacteria exposed to the anti-Gmd antibodies show evidence of exploding staph; however, additional research is being done to confirm this mechanism of action.

Second, researchers demonstrated that when mice were infused with the anti-Gmd antibody, and then exposed to MRSA, only about half of the mice developed the infection. As expected, Schwarz said, protection was dependent upon vaccine dose, with the lowest dose offering the least amount of protection.

"A vaccine in humans would probably not be a foolproof approach to preventing infection 100 percent of the time," Schwarz said. "However, even if we could reduce the risk of MRSA by 35 percent, that would be an enormous improvement in the field."

Researchers are seeking anti-Gmd agents with the best properties for binding to Gmd and making the bacteria less viable. This work is being led by scientists at Codevax LLC, a company started by the University of Rochester and private venture capitalists to co-develop and promote unlicensed vaccine technologies for infectious diseases. John Daiss, a scientist at Codevax, is leading the effort to find existing monoclonal antibodies with strong safety profiles such as those used to develop the cancer drugs Herceptin and Rituxan so that researcher can move quickly from the bench to initial clinical trials, Schwarz said.


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Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

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