Navigation Links
Researchers unveil vital key to cancer
Date:8/6/2008

rk will allow chemists to design an anti-cancer drug with fewer side effects, allowing scientists to assess the relative importance of Mps1 inhibition in different disease indications, including those that are currently hard to treat such as lung and pancreatic cancers.

Dr Eyers, whose findings are published in the Journal of Biological Chemistry (August 2008), said: "The crystallalographic structures of only a few key "mitotic" kinases are currently known so we are very early in the game. The scientific community has high hopes for developing novel "anti-mitotic" cancer therapies using this method of structure-based drug design.

"Mps1 is a rational target because of its critical role in preventing aneuploidy. We wanted to see what this protein looked like at the molecular level and, by revealing the active site "lock", help design a new inhibitory "key" to physically block the ATP-binding site.

His colleague Dr Lydia Tabernero added: "This work presents the first crystallographic structure of human Mps1, an important regulator of chromosomal stability and a potential target in cancer therapy. Our research has revealed several important structural features and additional binding sites that could be exploited for the development of specific Mps1 inhibitors."


'/>"/>

Contact: Mikaela Sitford
Mikaela.Sitford@manchester.ac.uk
01-612-752-111
University of Manchester
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... Brain not working? Functional medicine pioneer Datis ... minor brain problems as brain fog, memory loss, fatigue, ... indicate the brain may be degenerating—or aging—too quickly, raising ... and other neurological diseases. Why Isn’t My Brain ... is now available online at Amazon and ...
(Date:6/19/2013)... Chrysler made news recently when it refused to accept ... The Jeep models in question are the 1993-2004 Jeep Grand ... NHTSA are vulnerable to fire and explosion in a crash. ... and have been alleged to catch fire or explode upon ... 32 rear-end crashes, which resulted in 44 deaths and the ...
(Date:6/19/2013)... 2013 Citi Bike has come to New York ... David Perna to know for sure how many patients will choose ... they’ll have the option. In fact, he’s happy about anything ... also make it more convenient for them to visit his office ... of Complimentary Alternative Medicine at Back and Body Medical and an ...
(Date:6/19/2013)... Lawrence, KS (PRWEB) June 19, 2013 ... photographs is common with today’s computer software, it creates ... a form of misconduct. As an already published case ... of photo manipulation. , The Journal of Parasitology ... image manipulation in a 2004 article published in ...
(Date:6/19/2013)... LOS ANGELES (June 19, 2013) In what is ... with the most common form of hereditary dystonia ... experts in deep brain stimulation report good success ... director of the Movement Disorders Program at Cedars-Sinai Medical ... chief of the Division of Neurosurgery at Beth Israel ...
Breaking Medicine News(10 mins):Health News:Brain Not Working? Minor Symptoms Now Could Mean MS, Alzheimer's, or Parkinson's Later 2Health News:Brain Not Working? Minor Symptoms Now Could Mean MS, Alzheimer's, or Parkinson's Later 3Health News:Zinda & Davis PLLC: Why the Chrysler Recall Refusal Matters And May Set a Dangerous Precedent 2Health News:Zinda & Davis PLLC: Why the Chrysler Recall Refusal Matters And May Set a Dangerous Precedent 3Health News:New York City's Back and Body Medical Welcomes Citi Bike to Midtown Manhattan 2Health News:New York City's Back and Body Medical Welcomes Citi Bike to Midtown Manhattan 3Health News:Altered Photo in Journal Article Illustrates the Need for Manipulation Guidelines 2Health News:Long-term study reports deep brain stimulation effective for most common hereditary dystonia 2
... Joint distraction (the use of a surgical frame around a ... in severe end stage osteoarthritis (OA) of the knee, as ... EULAR 2008, the Annual Congress of the European League Against ... external fixation frame, with springs, was used to bridge the ...
... Paris, France, Friday 13 June 2008: Tocilizumab plus ... safety in patients with moderate to severe rheumatoid ... anti-tumour necrosis factor (anti-TNF) therapy, according to a ... Annual Congress of the European League Against Rheumatism ...
... WASHINGTON, June 13 A new "hospital ... gives the Department,s,health care system high marks, with ... commonly accepted by the health,care industry., "This ... of care VA,provides to our veterans," said Dr. ...
... Life Urges Congress to Preserve ... Compassionate End-of-Life Care, WASHINGTON, June 13 ... Commission (MedPAC),reported that the rapid growth of the Medicare hospice benefit ... spending per,beneficiary. According to the report, "Evaluating Medicare,s Hospice,Benefit," much more ...
... scene affected years later, with those injured suffering most , , ... after the World Trade Center terrorist attacks, one in eight ... post-traumatic stress disorder (PTSD), a New York City Health Department ... Manhattan residents is three times the usual rate and matches ...
... of cardiovascular disease (CVD) for people with rheumatoid arthritis (RA) ... CVD in people with type 2 diabetes, according to the ... Annual Congress of the European League Against Rheumatism in Paris, ... 8.6% of the RA population studied, a figure that was ...
Cached Medicine News:Health News:Joint distraction promotes structural repair in patients with severe knee osteoarthritis 2Health News:30 percent RA patients refractory to anti-TNFs achieve disease remission with tocilizumab plus metho 2Health News:Health Care 'Report Card' Gives VA High Marks 2Health News:More Data Needed Before Changing Medicare Hospice Funding, Report Finds 2Health News:More Data Needed Before Changing Medicare Hospice Funding, Report Finds 3Health News:PTSD High Among Witnesses to 9/11 2Health News:Rheumatoid arthritis is a risk factor for cardiovascular disease 2
(Date:6/19/2013)... June 19, 2013 The Physician-Patient Alliance for Health ... The need to urgently address this issue has ... Event Alert #50 , "Medical device alarm safety in hospitals." ... January 2008 and June 2012, there were 98 alarm related ... death (82%) , 13 resulted in permanent loss of ...
(Date:6/19/2013)... June 19, 2013   BioCision , a ... and handling in many areas of medical and ... patents by the U.S. Patent Office that apply ... to standardize sample handling to ensure the consistency ... common laboratory procedures. Patent number ...
(Date:6/19/2013)... 19, 2013 ... DrugPatentWatch to its extensive list of ...      (Logo: http://photos.prnewswire.com/prnh/20130128/590935) , ... pharmaceutical, drug patents and their expirations. ... business functions of patent agents and ...
Breaking Medicine Technology:Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 2Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 3BioCision Announces Two New U.S. Patents for Thermo-Conductive Products that Standardize Sample Handling in Laboratory Research 2Drug Patent Watch 2Drug Patent Watch 3
... of three test plates(6mm, 3mm, and 1.5mm thick), ... of 600 - 15 seconds. No special glasses ... detected if stereopsis is present. Test plates can ... patient learning the correct answer. Large stereo acuity ...
8 X 1 Red Filter. Color Filters are designed to filter out all other color regions of the visible spectrum except the specified color. Color Filters are excellent for contrast enhancement and color r...
Last 3-6 months average refrigeration will prolong life. Pupil gauge printed on penlight 4 1/2" long 1/2" around....
Doctors six-pack long lasting, disposable, diagnostic penlights. Constant use time of 30 minutes. One year shelf life warranty from date of purchase. Convenient clip-activated switch & imprinted medi...
Medicine Products: