Navigation Links
Researchers unlock new mechanism in pain management
Date:9/3/2014

It's in the brain where we perceive the unpleasant sensations of pain, and researchers have long been examining how calcium channels in the brain and peripheral nervous system contribute to the development of chronic pain conditions.

Neuroscientist Gerald Zamponi, PhD, and his team at the University of Calgary's Hotchkiss Brain Institute have discovered a new mechanism that can reverse chronic pain. Using an animal model, their research has found that pain signals in nerve cells can be shut off by interfering with the communication of a specific enzyme with calcium channels, a group of important proteins that control nerve impulses.

Their Canadian Institutes of Health Research (CIHR) funded study was published in the September issue of Neuron one of the most influential journals in the field of neuroscience.

Zamponi is now applying his research and partnering with the Centre for Drug Research and Development (CDRD) in Vancouver to develop a drug that could one day improve the lives of those with inflammatory pain such as arthritis, irritable bowel disease or neuropathic pain. Their approach may be able to reduce the pain associated with these conditions.

"Chronic pain can be a debilitating condition that affects many people and is often poorly controlled by currently available treatments. Therefore, new treatment avenues are needed. Our discovery opens the door towards new treatments, and based on the data that we have so far, it is a viable strategy," says Zamponi, the lead author of the study and senior associate dean of research at the Cumming School of Medicine.

With CDRD, Zamponi and his team are screening over 100,000 molecules in hopes of finding one that would stop the enzyme from communicating with the calcium channel. If they can isolate the right molecule, they can potentially turn it into a drug. So far, they have already found two viable molecules that have been validated by his group as painkillers in animals.

Commercialization of the project is possible as Zamponi and his team are one of six successful projects funded through the competition of the Alberta/Pfizer Translational Research Fund Opportunity. "AIHS is delighted that the strong partnership created with Pfizer, Western Economic Diversification, and Alberta Innovation and Advanced Education is helping to develop promising innovations from basic research into technologies, drugs, and tools to improve health," says Dr. Cy Frank, President & CEO of Alberta Innovates Health Solutions."


'/>"/>

Contact: Marta Cyperling
mcyperli@ucalgary.ca
403-210-3835
University of Calgary, Faculty of Medicine
Source:Eurekalert

Related medicine news :

1. Researchers demonstrate direct brain-to-brain communication in human subjects
2. Event Gathers World-Renowned Researchers and Community Leaders to Find a Cure for Rare Disease, Friedreich’s Ataxia
3. Prions can trigger stuck wine fermentations, researchers find
4. UTHealth researchers find up to 3,000 times the bacterial growth on hollow-head toothbrushes
5. University Of Iowa Celebrates The Dedication Of The Fraternal Order Of Eagles Diabetes Research Center - 100 Researchers Help Identify New Treatments & Cures For Diabetes
6. Influenced by Self-Interest, Humans Less Concerned About Inequity To Others, Researchers Find
7. Researchers examine impact of race and ethnicity in motor complete spinal cord injury
8. Researchers identify potential risk factors for urinary tract infections in young girls
9. Researchers found an important clue to potential treatments for absence seizures
10. Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma
11. Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... , ... ANGLESTRONG , the new recovery management app with multiple innovative ... Store and Google Play . Florida-based Sober Network, Inc., the premier provider ... with Angle to build ANGLESTRONG. The new recovery management app is a passion project ...
(Date:2/22/2017)... ... February 22, 2017 , ... Bellus Medical, a leader in ... the delivery of Platelet Rich Plasma (PRP). PRP systems are used by physicians ... tissue synthesis and provide a faster and more efficient healing process. There are ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... and 72 percent of those report that family members or friends have also ... they suffer from hearing loss wear hearing aids. One reason, suggested by 89 ...
(Date:2/22/2017)... ... February 22, 2017 , ... Pet obesity in the ... of dogs, according to the Association for Pet Obesity Prevention (APOP). During the ninth ... food issues such as the benefits of corn and grains, value of raw and ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... BrightStar ... several sponsors of the Medical University of South Carolina (MUSC) Center on Aging’s ... Pleasant, SC. “MUSC’s Center on Aging is a tremendous resource in our community. We ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... -- According to a new market research report "Gynecology ... (Laparoscopy, Colposcopy, Hysteroscopy, D&C, Ablation, Biopsy), & End User (Hospital, Clinic, ... the global market is expected to reach USD 2.44 Billion by ... 7.1% during the forecast period. Continue ... ...
(Date:2/22/2017)... PUNE, India , February 22, 2017 ... titled, "Automated Radio Synthesis Modules Market: Global Opportunity Analysis and ... market was worth $20 million in 2015 and projected to ... 6.6% from 2016 to 2022. North America ... market revenues and unit volumes, whereas Asia-Pacific ...
(Date:2/22/2017)... Conn. , Feb. 22, 2017   Protein ... maker of Flublok® Influenza Vaccine , announced today ... Partnership for Influenza Vaccine Introduction (PIVI) and the Mongolian ... devastating impacts of the flu.  The doses of Flublok ... Mongolia for health care workers, ...
Breaking Medicine Technology: