Navigation Links
Researchers unlock new mechanism in pain management
Date:9/3/2014

It's in the brain where we perceive the unpleasant sensations of pain, and researchers have long been examining how calcium channels in the brain and peripheral nervous system contribute to the development of chronic pain conditions.

Neuroscientist Gerald Zamponi, PhD, and his team at the University of Calgary's Hotchkiss Brain Institute have discovered a new mechanism that can reverse chronic pain. Using an animal model, their research has found that pain signals in nerve cells can be shut off by interfering with the communication of a specific enzyme with calcium channels, a group of important proteins that control nerve impulses.

Their Canadian Institutes of Health Research (CIHR) funded study was published in the September issue of Neuron one of the most influential journals in the field of neuroscience.

Zamponi is now applying his research and partnering with the Centre for Drug Research and Development (CDRD) in Vancouver to develop a drug that could one day improve the lives of those with inflammatory pain such as arthritis, irritable bowel disease or neuropathic pain. Their approach may be able to reduce the pain associated with these conditions.

"Chronic pain can be a debilitating condition that affects many people and is often poorly controlled by currently available treatments. Therefore, new treatment avenues are needed. Our discovery opens the door towards new treatments, and based on the data that we have so far, it is a viable strategy," says Zamponi, the lead author of the study and senior associate dean of research at the Cumming School of Medicine.

With CDRD, Zamponi and his team are screening over 100,000 molecules in hopes of finding one that would stop the enzyme from communicating with the calcium channel. If they can isolate the right molecule, they can potentially turn it into a drug. So far, they have already found two viable molecules that have been validated by his group as painkillers in animals.

Commercialization of the project is possible as Zamponi and his team are one of six successful projects funded through the competition of the Alberta/Pfizer Translational Research Fund Opportunity. "AIHS is delighted that the strong partnership created with Pfizer, Western Economic Diversification, and Alberta Innovation and Advanced Education is helping to develop promising innovations from basic research into technologies, drugs, and tools to improve health," says Dr. Cy Frank, President & CEO of Alberta Innovates Health Solutions."


'/>"/>

Contact: Marta Cyperling
mcyperli@ucalgary.ca
403-210-3835
University of Calgary, Faculty of Medicine
Source:Eurekalert

Related medicine news :

1. Researchers demonstrate direct brain-to-brain communication in human subjects
2. Event Gathers World-Renowned Researchers and Community Leaders to Find a Cure for Rare Disease, Friedreich’s Ataxia
3. Prions can trigger stuck wine fermentations, researchers find
4. UTHealth researchers find up to 3,000 times the bacterial growth on hollow-head toothbrushes
5. University Of Iowa Celebrates The Dedication Of The Fraternal Order Of Eagles Diabetes Research Center - 100 Researchers Help Identify New Treatments & Cures For Diabetes
6. Influenced by Self-Interest, Humans Less Concerned About Inequity To Others, Researchers Find
7. Researchers examine impact of race and ethnicity in motor complete spinal cord injury
8. Researchers identify potential risk factors for urinary tract infections in young girls
9. Researchers found an important clue to potential treatments for absence seizures
10. Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma
11. Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Lori G. Cohen and ... will speak at the American Conference Institute’s 21st Drug & Medical Device Litigation ... Lead Sponsor of the conference. , Cohen, who chairs the firm’s Pharmaceutical, Medical Device ...
(Date:12/2/2016)... ... 2016 , ... More than 100 business, civic, community and ... the UNCF Dothan-Wiregrass Mayor’s Luncheon Dec. 9, 2016. This inaugural event, hosted by ... support to UNCF-member institutions, including Miles College, Oakwood University, Tuskegee University, Stillman College ...
(Date:12/2/2016)... ... 2016 , ... The annual time frame to change Medicare health and prescription ... December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current plan ... to make changes during this period order for their new policy to go into ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi Hovsepian, ... included in the 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive ... of their education, experience, and professional associations. , One the most frequently ...
(Date:12/2/2016)... Hawaii (PRWEB) , ... December 02, 2016 , ... ... 2016 at the Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, offering ... in the field of pain management. , The demand for supplemental training ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... in the ECG Cables And ECG Leadwires Market owing to ... devices. On the other hand, the Asia-Pacific ... rate during the forecast period. The market players ... plc ( Ireland ), Koninklijke Philips N.V. ( ... ( China ), held major share of the ...
(Date:12/2/2016)... 2016 Quantum Radiology,s Mobile Breast Center (QR ... directly to women at the workplace, thereby maximizing convenience ... Delta Air Lines and SunTrust Bank, and community health ... of wellness initiatives. "I think it,s a ... them to have a mammogram without taking a large ...
(Date:12/2/2016)... Dec. 2, 2016  Eli Lilly and Company (NYSE: ... for 2017 and provide updated financial guidance for 2016 ... a conference call on that day with the investment ... guidance. The conference call will begin at ... can access a live webcast of the conference call ...
Breaking Medicine Technology: