Navigation Links
Researchers unlock new mechanism in pain management
Date:9/3/2014

It's in the brain where we perceive the unpleasant sensations of pain, and researchers have long been examining how calcium channels in the brain and peripheral nervous system contribute to the development of chronic pain conditions.

Neuroscientist Gerald Zamponi, PhD, and his team at the University of Calgary's Hotchkiss Brain Institute have discovered a new mechanism that can reverse chronic pain. Using an animal model, their research has found that pain signals in nerve cells can be shut off by interfering with the communication of a specific enzyme with calcium channels, a group of important proteins that control nerve impulses.

Their Canadian Institutes of Health Research (CIHR) funded study was published in the September issue of Neuron one of the most influential journals in the field of neuroscience.

Zamponi is now applying his research and partnering with the Centre for Drug Research and Development (CDRD) in Vancouver to develop a drug that could one day improve the lives of those with inflammatory pain such as arthritis, irritable bowel disease or neuropathic pain. Their approach may be able to reduce the pain associated with these conditions.

"Chronic pain can be a debilitating condition that affects many people and is often poorly controlled by currently available treatments. Therefore, new treatment avenues are needed. Our discovery opens the door towards new treatments, and based on the data that we have so far, it is a viable strategy," says Zamponi, the lead author of the study and senior associate dean of research at the Cumming School of Medicine.

With CDRD, Zamponi and his team are screening over 100,000 molecules in hopes of finding one that would stop the enzyme from communicating with the calcium channel. If they can isolate the right molecule, they can potentially turn it into a drug. So far, they have already found two viable molecules that have been validated by his group as painkillers in animals.

Commercialization of the project is possible as Zamponi and his team are one of six successful projects funded through the competition of the Alberta/Pfizer Translational Research Fund Opportunity. "AIHS is delighted that the strong partnership created with Pfizer, Western Economic Diversification, and Alberta Innovation and Advanced Education is helping to develop promising innovations from basic research into technologies, drugs, and tools to improve health," says Dr. Cy Frank, President & CEO of Alberta Innovates Health Solutions."


'/>"/>

Contact: Marta Cyperling
mcyperli@ucalgary.ca
403-210-3835
University of Calgary, Faculty of Medicine
Source:Eurekalert

Related medicine news :

1. Researchers demonstrate direct brain-to-brain communication in human subjects
2. Event Gathers World-Renowned Researchers and Community Leaders to Find a Cure for Rare Disease, Friedreich’s Ataxia
3. Prions can trigger stuck wine fermentations, researchers find
4. UTHealth researchers find up to 3,000 times the bacterial growth on hollow-head toothbrushes
5. University Of Iowa Celebrates The Dedication Of The Fraternal Order Of Eagles Diabetes Research Center - 100 Researchers Help Identify New Treatments & Cures For Diabetes
6. Influenced by Self-Interest, Humans Less Concerned About Inequity To Others, Researchers Find
7. Researchers examine impact of race and ethnicity in motor complete spinal cord injury
8. Researchers identify potential risk factors for urinary tract infections in young girls
9. Researchers found an important clue to potential treatments for absence seizures
10. Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma
11. Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... April 30, 2016 , ... The ... , a program to critically evaluate and rank health-focused applications and connected devices ... to provide independent, unbiased and accurate information to help accelerate patient and provider ...
(Date:4/30/2016)... (PRWEB) , ... April 30, 2016 , ... Orlando-based Maximized ... as they go for gold in Rio. Under the care of Maximized Living ... golds! , In an unprecedented showing, Maximized Living is sending the largest contingent of ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... notified by the Accreditation Council for Graduate Medical Education (ACGME) that it has ... This is the first accreditation of three residency programs that Memorial is currently ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... ... advocating optimistic healthcare awareness and author of best seller "LOVE, MEDICINE and MIRACLES") ... Radio Monday, May 2, 2016 and podcasted thereafter . Dr. Bernie Siegel, ...
(Date:4/29/2016)... ... 2016 , ... Spine Team Texas, a comprehensive spine physician group specializing in ... physicians has been invited to be a featured speaker at the Texas Society of ... April 30, 2016. , Dr. R. Scott McPherson, a physical medicine and rehabilitation ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... Switzerland , April 27, 2016 ... AG announced the launch of a Phase 2 clinical ... residual hearing in patients undergoing cochlear implantation (CI) surgery. ... recruiting patients in Germany and ... into the middle ear at the time of surgery. ...
(Date:4/26/2016)... 26, 2016 Hill-Rom Holdings, Inc. (NYSE: ... at the Deutsche Bank 41 st Annual Health Care ... You are invited to listen to the live ... access it directly at http://edge.media-server.com/m/p/mr4uxgas . A recorded replay ... of the live event and accessible at the links above ...
(Date:4/26/2016)... , April 27, 2016 Research ... "Global Molecular Diagnostics Market 2016-2020" report to their ... , ,The global molecular diagnostics market is projected to ... 2016-2020. Molecular diagnostics is a technique that ... the molecular level to detect changes in biochemical pathways. ...
Breaking Medicine Technology: