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Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
Date:9/10/2007

. The overall size of the cortex stayed the same.

Our findings imply that Emx2 and COUP-TF1 work in opposing ways, says OLeary. While Emx2 works in a positive manner to specify the area identity of visual neurons, the presence of COUP-TF1 prevents progenitor cells from taking on a motor area identity.

Although the mice lacking COUP-TF1 in their cortex do not have any obvious sensory or motor problems, the researchers believe that a closer look will reveal substantial deficits. Their prediction is based on a study published by OLeary and his colleagues earlier this year. They found that individual areas must be the right size relative to each other or mice will underperform in tests of their skills at the relevant behaviors.


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Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

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