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Researchers uncover new insights into developing rapid-acting antidepressant for treatment-resistant depression
Date:6/12/2014

e new findings point a way to blocking NMDA receptors to control depression with fewer side effects.

Dr. Monteggia's lab focuses on the molecular and cellular bases of neural plasticity, the fundamental property of nerve cells to alter their communication, as they pertains to neuropsychiatric disorders, as well as understanding the mechanisms underlying antidepressant efficacy.

Guidelines by the American Psychiatric Association suggest medications are the preferred treatment for moderate to severe depressive symptomatology. About one in 10 people in the U.S. aged 12 and over takes anti-depressant medication, and about 14 percent of those individuals taking antidepressant medication have done so for 10 years or longer.

Antidepressants were the third most common prescription drug taken by Americans of all ages between 2005 and 2008, and the most frequently used prescription drug by people 18 to 44 years old, according to surveys by the Centers for Disease Control. According to the CDC, comparing the 1988-1994 period with the 2005-2008 period, the average rate of antidepressant use in the U.S. among all ages increased nearly 400 percent.

Overall, women are two and a half times more likely to take antidepressant medication as men, with 23 percent of women aged 40 to 59 taking antidepressants more than in any other group.

The CDC estimates that nearly 8 percent of people over age 12 report being currently depressed, with women reporting higher rates of depression than males in every age group. Women between 40 and 59 years have the highest rates of depression (about 12 percent). Depression generates more than 8 million visits to physician offices, hospital outpatient and emergency departments, and nearly 400,000 in-patient stays, which average 6.5 days.


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Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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