Navigation Links
Researchers uncover new insights into developing rapid-acting antidepressant for treatment-resistant depression
Date:6/12/2014

DALLAS June 12, 2014 UT Southwestern Medical Center researchers have generated fresh insights that could aid in the development of rapid-acting antidepressants for treatment-resistant depression.

The researchers found that by blocking NMDA receptors with the drug ketamine, they could elicit rapid antidepressant effects in patients with treatment-resistant depression. Ketamine was developed as an anesthetic, but is better known publicly for its abuse as the party drug Special K. Researchers are now seeking alternatives because ketamine can produce side effects that include hallucinations and the potential for abuse limiting its utility as an antidepressant.

Therefore, researchers had been investigating a drug called memantine, currently FDA-approved for treating moderate to severe Alzheimer's disease, as a potentially promising therapy for treatment-resistant depression. Memantine acts on the same receptors in the brain as fast-acting ketamine, said Dr. Lisa Monteggia, Professor of Neuroscience. However, recent clinical data suggest that memantine does not exert rapid antidepressant action for reasons that are poorly understood.

"Although, both ketamine and memantine have similar actions when nerve cells are active, under resting conditions, memantine is less effective in blocking nerve cell communication compared to ketamine, This fundamental difference in their action could explain why memantine has not been effective as a rapid antidepressant" said Dr. Monteggia, who holds the Ginny and John Eulich Professorship in Autism Spectrum Disorders.

The different effects of ketamine and memantine alter signals emanating from NMDA receptors, in particular those that determine antidepressant efficacy. Dr. Monteggia noted that the new findings point a way to blocking NMDA receptors to control depression with fewer side effects.

Dr. Monteggia's lab focuses on the molecular and cellular bases of neural plasticity, the fundamental property of nerve cells to alter their communication, as they pertains to neuropsychiatric disorders, as well as understanding the mechanisms underlying antidepressant efficacy.

Guidelines by the American Psychiatric Association suggest medications are the preferred treatment for moderate to severe depressive symptomatology. About one in 10 people in the U.S. aged 12 and over takes anti-depressant medication, and about 14 percent of those individuals taking antidepressant medication have done so for 10 years or longer.

Antidepressants were the third most common prescription drug taken by Americans of all ages between 2005 and 2008, and the most frequently used prescription drug by people 18 to 44 years old, according to surveys by the Centers for Disease Control. According to the CDC, comparing the 1988-1994 period with the 2005-2008 period, the average rate of antidepressant use in the U.S. among all ages increased nearly 400 percent.

Overall, women are two and a half times more likely to take antidepressant medication as men, with 23 percent of women aged 40 to 59 taking antidepressants more than in any other group.

The CDC estimates that nearly 8 percent of people over age 12 report being currently depressed, with women reporting higher rates of depression than males in every age group. Women between 40 and 59 years have the highest rates of depression (about 12 percent). Depression generates more than 8 million visits to physician offices, hospital outpatient and emergency departments, and nearly 400,000 in-patient stays, which average 6.5 days.


'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. Broad Institute, MGH researchers chart cellular complexity of brain tumors
2. Researchers uncover common heart drugs link to diabetes
3. Mayo Clinic researchers discover new form of cancer
4. Researchers recast addiction as a manageable disease
5. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
6. Berkeley Lab researchers create nanoparticle thin films that self-assemble in 1 minute
7. Study shows health policy researchers lack confidence in social media for communication
8. Researchers at the Gladstone Institutes find novel approach to reactivate latent HIV
9. UO researchers use rhythmic brain activity to track memories in progress
10. FAPESP announces the SPRINT -- Sao Paulo Researchers in International Collaboration
11. UCLA researchers identify new gene involved in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers uncover new insights into developing  rapid-acting antidepressant for treatment-resistant depression
(Date:1/17/2017)... ... ... Stalking Awareness Month (NSAM), now in its fourteenth year, when we turn the spotlight ... a very real danger to many in our community. We also take a look ... “Stalking: know it. Name it. Stop it.”—so reads the theme for this importance observance. ...
(Date:1/17/2017)... CA (PRWEB) , ... January 17, 2017 , ... ... concerned by the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting interview with ... magical moments that help everyone endure and pass through tough times, Dr. Bernie ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... century approach to infusing high speed technology into the fabric of an entire ... the advancement of healthcare and wellness in a yet-to-be-named, health focused campus. Leading ...
(Date:1/17/2017)... ... January 17, 2017 , ... Surgeons from New York’s fastest ... practitioners on the latest breakthroughs in the prevention, diagnosis and treatment of the ... to eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive Officer of SightMD and ...
(Date:1/17/2017)... ... January 17, 2017 , ... SC&H Group, a leading audit, tax, ... in its IT Advisory Services practice . Rossi is the third technology consulting ... for strategic IT guidance grows, and the practice continues to expand.     , Bringing more ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 2017  Market Research Future published a Half Cooked Research Report ... to reach USD 33.6 million during the period 2016 to 2022 ... ... Market has been examined as a swiftly growing market and expected ... for endoscopy device in various regions.  The increasing growth in endoscopy ...
(Date:1/17/2017)... Research and Markets has announced the addition of the ... their offering. ... The global fluoropolymer market in the healthcare industry to grow at ... Global Fluoropolymer Market in the Healthcare Industry 2016-2020, has been prepared ... The report covers the market landscape and its growth prospects over ...
(Date:1/17/2017)... , Jan. 17, 2017   Tocagen Inc ., a ... , Ph.D., executive vice president, research and pharmaceutical development at Tocagen, ... , to be held Jan. 17-20 in Miami ... follows: ... biotech oxymoron: exciting manufacturing for replicating viruses - what to do ...
Breaking Medicine Technology: