Navigation Links
Researchers uncover gene's role in rheumatoid arthritis, findings pave way for new treatments
Date:1/24/2013

ANN ARBOR, Mich. University of Michigan research sheds new light on why certain people are more likely to suffer from rheumatoid arthritis paving the way to explore new treatments for both arthritis and other autoimmune diseases.

The new UMHS research in mice identifies how a specific group of genes works behind the scenes to activate the bone-destroying cells that cause severe rheumatoid arthritis, a debilitating health issue for millions of Americans.

"We believe this could be a significant breakthrough in our understanding of why certain genes are associated with higher risk of rheumatoid arthritis and other autoimmune diseases a link that has been a mystery in the field for decades," says lead author Joseph Holoshitz, M.D., professor of internal medicine and associate chief of research in the division of rheumatology at the U-M School of Medicine.

"We hope that this improved understanding will open the door to future design of drugs to treat this crippling disease and autoimmune disease in general."

The research appeared in The Journal of Immunology and was highlighted by Nature Reviews Rheumatology.

Rheumatoid arthritis is a chronic inflammatory disorder that damages the lining of joints and causes bone erosion, joint deformity and disability. The disease is an autoimmune disorder, characterized by the body's immune system mistakenly attacking the body's tissues.

Researchers have long studied the phenomenon of why certain versions of an inherited group of genes known as "human leukocyte antigen" (HLA) are associated with autoimmune disorders. One subset of these HLA genes that codes a protein sequence called "shared epitope" represents the most significant genetic risk factor for rheumatoid arthritis, affecting disease susceptibility and severity. However, until now, the reason for this strong link has been unclear.

A common theory in the field has been that the association between particular HLA genes and autoimmune diseases is a result of mistakenly identifying body tissues as foreign making the body the target of the immune system and setting off an attack on self-tissues, which results in disease.

The UMHS research challenges this long-held theory. The study shows, for the first time, how this subset of HLA genes causes arthritis by activating inflammation-causing cells, as well as bone-destroying cells (known as osteoclasts). This leads to severe arthritis and bone erosion.

"We showed how the shared epitope is directly triggering osteoclasts, the very cells that are responsible for joint destruction in people with the disease," says Holoshitz.

"Understanding these mechanisms at play could be a significant piece of future drug development. Because we now know the molecular mechanism that activates arthritis-causing cells, we have the potential to block that pathway with simple chemical compounds that could be used to treat rheumatoid arthritis and other diseases."


'/>"/>

Contact: Beata Mostafavi
bmostafa@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. New drug improves survival in multiple myeloma relapse, Moffitt Cancer Center researchers say
2. Researchers discover promising prognostic marker for aggressive breast cancer
3. Researchers design a new imaging technique for identifying the age and sex of a corpse
4. Researchers map emotional intelligence in the brain
5. Researchers find that simple blood test can help identify trauma patients at greatest risk of death
6. Mayo Clinic researchers identify enzyme involved in deadly brain tumors
7. UNC researchers use luminescent mice to track cancer and aging in real-time
8. Gothenburg researchers make world top 10
9. Autism Researchers Surprised by Impaired Brain Connections
10. Researchers identify ways to improve quality of care measurement from electronic health records
11. Researchers identify genetic mutation for rare cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers uncover gene's role in rheumatoid arthritis, findings pave way for new treatments
(Date:2/24/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals (iaedp) announces the ... body image mannequin art competition. Selected from 15 submissions from around the nation, the ... the 31st annual iaedp Symposium, March 22 – 26 in Las Vegas. , This ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... The ... for excellence in radiology marketing programs at the annual Building Better Radiology Marketing ... Renaissance Fort Worth Hotel in Fort Worth, Texas. Nine awards are given out in ...
(Date:2/24/2017)... Emeryville, CA (PRWEB) , ... February 24, 2017 ... ... Esparza for qualifying into the Senior International Elite division on February 12th. ... All Around divisions at the elite qualifier competition held in Las Vegas, Nevada. ...
(Date:2/23/2017)... TX (PRWEB) , ... February 23, 2017 , ... ... announced an official 2017 partnership with The Jensie Gran Fondo of Marin. For ... and UVB rays with Thinksport’s broad-spectrum, mineral-based sunscreen. , “We are thrilled to ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... The 89th ... the winner of the 2016 National Education Policy Center Bunkum Award. We invite you ... in 2016. , This year’s Bunkum winner is the Center for American Progress (CAP), ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Feb 23, 2017 Research and Markets has ... and Strategies - 2016" report to their offering. ... The latest research Oesophageal ... data and benchmarks in the global Oesophageal Cancer market. ... What are the key drugs marketed for Oesophageal Cancer and their ...
(Date:2/23/2017)... CITY, Calif. , Feb. 23, 2017 /PRNewswire/ ... pharmaceutical company focused on the development and commercialization ... acute pain, announced that it will release fourth ... on Thursday, March 2nd, 2017. AcelRx management will ... Eastern Time (1:30 p.m. Pacific Time) on March ...
(Date:2/23/2017)... 2017 Obese people are seldom ... varicose veins in their body. The rising number of ... adoption of endovenous laser therapy for treatment of varicose ... therapy market, published by Future Market Insights, indicates ... consequences of obesity have collectively factored the growth in ...
Breaking Medicine Technology: