Navigation Links
Researchers uncover gene's role in rheumatoid arthritis, findings pave way for new treatments
Date:1/24/2013

ANN ARBOR, Mich. University of Michigan research sheds new light on why certain people are more likely to suffer from rheumatoid arthritis paving the way to explore new treatments for both arthritis and other autoimmune diseases.

The new UMHS research in mice identifies how a specific group of genes works behind the scenes to activate the bone-destroying cells that cause severe rheumatoid arthritis, a debilitating health issue for millions of Americans.

"We believe this could be a significant breakthrough in our understanding of why certain genes are associated with higher risk of rheumatoid arthritis and other autoimmune diseases a link that has been a mystery in the field for decades," says lead author Joseph Holoshitz, M.D., professor of internal medicine and associate chief of research in the division of rheumatology at the U-M School of Medicine.

"We hope that this improved understanding will open the door to future design of drugs to treat this crippling disease and autoimmune disease in general."

The research appeared in The Journal of Immunology and was highlighted by Nature Reviews Rheumatology.

Rheumatoid arthritis is a chronic inflammatory disorder that damages the lining of joints and causes bone erosion, joint deformity and disability. The disease is an autoimmune disorder, characterized by the body's immune system mistakenly attacking the body's tissues.

Researchers have long studied the phenomenon of why certain versions of an inherited group of genes known as "human leukocyte antigen" (HLA) are associated with autoimmune disorders. One subset of these HLA genes that codes a protein sequence called "shared epitope" represents the most significant genetic risk factor for rheumatoid arthritis, affecting disease susceptibility and severity. However, until now, the reason for this strong link has been unclear.

A common theory in the field has been that the associa
'/>"/>

Contact: Beata Mostafavi
bmostafa@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New drug improves survival in multiple myeloma relapse, Moffitt Cancer Center researchers say
2. Researchers discover promising prognostic marker for aggressive breast cancer
3. Researchers design a new imaging technique for identifying the age and sex of a corpse
4. Researchers map emotional intelligence in the brain
5. Researchers find that simple blood test can help identify trauma patients at greatest risk of death
6. Mayo Clinic researchers identify enzyme involved in deadly brain tumors
7. UNC researchers use luminescent mice to track cancer and aging in real-time
8. Gothenburg researchers make world top 10
9. Autism Researchers Surprised by Impaired Brain Connections
10. Researchers identify ways to improve quality of care measurement from electronic health records
11. Researchers identify genetic mutation for rare cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers uncover gene's role in rheumatoid arthritis, findings pave way for new treatments
(Date:12/19/2014)... (PRWEB) December 19, 2014 From November 24, ... teacher training for the year 2014 in its Goa ... this year. Through the Indian winters, from November to March, ... the beautiful beach of Arambol, Goa. The Goa training sessions ... previous intakes of yoga teacher training, the 10th intake is ...
(Date:12/19/2014)... Dallas, TX (PRWEB) December 19, 2014 ... current state of the global Gliquidone industry with a ... statistics on the market status of the Gliquidone manufacturers ... for companies and individuals interested in the industry. , ... industry including its definition, applications and manufacturing technology. Then, ...
(Date:12/19/2014)... 18, 2014 (HealthDay News) -- Being in good shape seems ... They looked at data from more than 57,000 Americans, ... treadmill tests between 1991 and 2009. Those in the ... having high blood pressure at the start of the study, ... levels of fitness. Of the more than 8,000 people ...
(Date:12/19/2014)... HealthDay Reporter THURSDAY, Dec. 18, ... exposed to high levels of air pollution late in pregnancy ... study suggests. Researchers found that of nearly 1,800 U.S. ... to the most air pollution during pregnancy were twice as ... exposure during the third trimester, specifically, showed the strongest correlation ...
(Date:12/19/2014)... News) -- Prostaglandin analogue eye drops -- a common ... of vision loss in patients with the eye disease, ... David Garway-Heath, of the Moorfields Eye Hospital and UCL ... than 500 people newly diagnosed with open-angle glaucoma -- ... of the leading causes of blindness. About 45 ...
Breaking Medicine News(10 mins):Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 3Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 2Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 3Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 4Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 5Health News:Gliquidone Industry Global and China Analysis for 2019, Now Available at ReportsnReports.com 6Health News:Being Fit Keeps Blood Pressure in Check 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 3Health News:Study Supports Benefit of Widely Used Glaucoma Drug 2
... uncertainty about risks and benefits of mastectomies or lumpectomies. ... the women diagnosed with early-stage breast cancer clearly understand ... breast-conserving lumpectomy plus radiation, even after they have one ... If the woman is black or Hispanic, the chances ...
... CNS Response,Inc. (OTC Bulletin Board: CNSO) ... roll out referenced-EEG(R) (rEEG(R)) availability with an,undisclosed, ... enables psychiatrists under the management of the ... to treat their most,therapy-challenged patients suffering any ...
... LCA-Vision Inc. (Nasdaq:,LCAV), a leading provider of ... the opening of its 76th LasikPlus(R) vision,center in ... vision center opened this year, and the second ... a LasikPlus(R) vision,center in Paramus in April 2006., ...
... surgeons precise fingertip power control during laparoscopic procedures while, ... first in ... the healthcare industry, BOULDER, ... unique opportunity to offer surgeons greater control,and precision during surgeries ...
... 31 Ingenuity Systems, the,leading provider of ... that Path Designer, the new pathway publishing ... Best New Product by the scientific community ... San Francisco. Path,Designer enables researchers to create ...
... the United States face strikingly high levels of stigma, according ... AIDS Research. , The amfAR survey results will be ... 9 a.m. at the National Press Clubs 13th Floor First ... The press conference will be followed by a briefing in ...
Cached Medicine News:Health News:Many Women Unclear About Breast Cancer Treatments 2Health News:CNS Response, Inc. Enters Agreement to Introduce rEEG(R) Platform to Managed Behavioral Health Organization 2Health News:CNS Response, Inc. Enters Agreement to Introduce rEEG(R) Platform to Managed Behavioral Health Organization 3Health News:CNS Response, Inc. Enters Agreement to Introduce rEEG(R) Platform to Managed Behavioral Health Organization 4Health News:LCA-Vision Announces the Opening of its 76th LasikPlus(R) Vision Center in Woodbridge, New Jersey 2Health News:Encision Moves Power and Safety to Surgeons' Fingertips 2Health News:Ingenuity's Path Designer is Selected as Best New Product by Life Science Community at 2008 Molecular Medicine Conference 2Health News:Ingenuity's Path Designer is Selected as Best New Product by Life Science Community at 2008 Molecular Medicine Conference 3Health News:Stigma clings stubbornly to women living with HIV/AIDS 2Health News:Stigma clings stubbornly to women living with HIV/AIDS 3
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 ... ;  Sorrento), an oncology company developing new treatments ... a privately-held immuno-oncology company developing proprietary Neukoplast ® ... therapy, announced today that the companies have entered ... generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the ...
(Date:12/19/2014)... 18, 2014 Research and Markets ... the "Micro Market Monitor: North American Dermatology ... http://photos.prnewswire.com/prnh/20130307/600769 ... steadily, which has resulted in fueling the overall ... main purpose of these dermatology devices is to ...
(Date:12/19/2014)... CITY, Calif., Dec. 18, 2014 Capnia, ... the development of medical diagnostics based on its ... gas flow, today announced financial results for the ... 2014. "Following the completion of our ... positioned to maximize the recently initiated CoSense® commercial ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8
... The Varitronics' Chan Wristrest is the standard for ... Its height is easily adjustable and its bar ... to the patient's eye. It allows the surgeon ... maximum control of the fine finger movements necessary ...
Titanium. Straight shafts with curved lower tip. Upper tip fits into positioning hole while lower jaw stabilizes the lens. Flat smooth handle with dull finish. Most popular size or model....
Hydroview insertion forcep with very thin jaws to allow insertion through tunnel or clear cornea incision. Locking. Made in titanium....
... Hall inserter is ideal for insertions of the ... jaws are textured to prevent migration of the ... flattened round handle eases fingertip manipulations of the ... A lock is provided for ease of loading ...
Medicine Products: