Navigation Links
Researchers uncover cause of gum disease related to type 2 diabetes
Date:7/31/2014

Going to the dentist isn't fun for anyone, but for those with periodontal disease related to type 2 diabetes, a new research discovery may have them smiling. In a report appearing in the August 2014 issue of the Journal of Leukocyte Biology, one of the most important blood cells involved in the human immune response, B cells, are shown to promote inflammation and bone loss in type 2 diabetes-associated periodontal disease. These findings support the idea that treatments that manipulate the responses of B cells may treat or prevent this complication.

"Our study identified common inflammatory mechanisms shared by type 2 diabetes and periodontal disease. It paves the way for the development of novel therapeutics which aim to simultaneously treat both type 2 diabetes and its complications," said Min Zhu, Ph.D., a researcher involved in the work from the department of microbiology at Boston University School of Medicine in Boston, Massachusetts.

To make this discovery, scientists used an experimental model (mouse model) of periodontal disease and applied it to two groups. The first group had a genetic alteration that knocked out all B cells. The second group had normal B cell levels. When fed a low-fat diet, without development of obesity and type 2 diabetes, both groups demonstrated a similar extent of oral bone loss and inflammation. However, when they were fed a high-fat diet, became obese and developed type 2 diabetes, oral bone loss and inflammation occurred in the normal group with B cells, but did not develop in the group with the altered gene to knock out the B cells. This suggests that the B cell-response might be a viable target for pharmacological intervention in both type 2 diabetes and periodontal disease, as well as potentially in other type 2 diabetes complications.

"This is an exciting study that helps us better understand why some complications related
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. U-M researchers find protein that fuels repair of treatment-resistant cancer cells
2. Neuro researchers advocate for a shift in thinking for stroke rehabilitation
3. Penn researchers: Naltrexone may diminish impulse control disorders in Parkinsons disease patients
4. Brazilian researchers identify RNA that regulates cell death
5. Researchers take steps toward development of a vaccine against tick-transmitted disease
6. UTSW cancer researchers identify irreversible inhibitor for KRAS gene mutation
7. Researchers identify potential biomarker for AD
8. BU researchers discover that Klotho is neuroprotective against Alzheimers disease
9. Researchers discover new way to determine cancer risk of chemicals
10. A world first: Researchers identify a treatment that prevents tumor metastasis
11. Researchers unlock the protein puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... York, New York (PRWEB) May 05, 2015 ... lawsuits ( http://www.testosteronelawsuithub.com/ ) filed on behalf ... complications due to their use of prescription ... in the federal multidistrict litigation underway in ... According to court documents dated May 1st, ...
(Date:5/5/2015)... York, NY (PRWEB) May 05, 2015 The newly ... on the experiences of Dr. Brad Reedy from his ... Judith Regan was asked why she chose to publish a parenting ... as a parent (and publisher) is the idea that it is ... we and our children are on the trek sometimes together and ...
(Date:5/5/2015)... 05, 2015 Dr. Patricia George knows ... (PH). A pulmonologist and pulmonary hypertension specialist at the ... a work event when an initial idea entered her ... sitting in the audience at the 2010 PHA International ... healthcare providers – were recalling their climb up Mt. ...
(Date:5/5/2015)... 05, 2015 " QuickPick Travel ” was ... which takes a look small, medium, and large businesses making ... NewsWatch and a business expert, conducted the business review and ... plan up to three weeks of vacation for free. , ... friends, and explore the world. And when people are preparing ...
(Date:5/5/2015)... May 05, 2015 MAP Health Management, ... revenue cycle management for addiction treatment facilities, announced today ... President of Business Development. Mr. Mooney, who has more ... field, will be responsible for developing new strategic partnerships ... MAP’s core products and new initiatives. , Prior to ...
Breaking Medicine News(10 mins):Health News:Federal Testosterone Lawsuit Defendants Recently Submitted Answers to Master Long Form Complaint 2Health News:Federal Testosterone Lawsuit Defendants Recently Submitted Answers to Master Long Form Complaint 3Health News:Federal Testosterone Lawsuit Defendants Recently Submitted Answers to Master Long Form Complaint 4Health News:The Last Parenting Book You Will Ever Need: Veteran Publisher Judith Regan Releases A Provocative New Book By Dr. Brad Reedy, "The Journey Of The Heroic Parent" 2Health News:The Last Parenting Book You Will Ever Need: Veteran Publisher Judith Regan Releases A Provocative New Book By Dr. Brad Reedy, "The Journey Of The Heroic Parent" 3Health News:World PH Day: Team PHenomenal Hope Races to Spread the Word about Pulmonary Hypertension 2Health News:A Platform to Plan the Perfect Vacation was Featured on NewsWatch Television 2Health News:Jimmy Mooney, an Addiction Treatment Veteran, Named Vice President of Business Development at MAP Health Management, LLC 2
... This release is available in German . ... problem in AIDS . Shortly after an individual becomes infected ... in this organ for life. Many HIV-infected individuals experience disturbances ... dementia. How the virus causes brain disease is still unclear. ...
... Fla., March 4 Viles & Beckman,LLC revealed today ... killed or crippled by side effects, such as renal ... into patients while,undergoing open heart surgery -- Trasylol -- ... Trasylol was recalled from the US market in,November 2007 ...
... LA JOLLA, CA A nuclear receptor protein, known ... also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis ... to new research by scientists at the Salk Institute ... Health. , Their findings, reported in this weeks ...
... for shamans and herb women? Not at all, for many ... products or were developed on the basis of natural substances. ... made from yew trees. The popular periwinkle plant, which grows ... of vinca alkaloids that are effective, for example, against malignant ...
... Developer,s Foundation to Lead the ... Ending Global Hunger, Improving Nutrition, NEW YORK, March ... a $15 million challenge grant to transform The Hebrew,University ... in Rehovot, Israel. The gift will be the cornerstone ...
... in training have a 17 percent less chance of ... surgery at non-teaching hospitals, according to results of a ... the Annals of Thoracic Surgery. , Theres a ... because of training issues, and concerns are frequently voiced ...
Cached Medicine News:Health News:Neural progenitor cells as reservoirs for HIV in the brain 2Health News:Drug Risk Harms 10,000+ Floridians 2Health News:New potential drug target for the treatment of atherosclerosis 2Health News:New potential drug target for the treatment of atherosclerosis 3Health News:Screening the herbal pharmacy 2Health News:Robert H. Smith 'Feeding the Future' with $15 Million Gift to Hebrew University of Jerusalem 2Health News:Risk of surgery for lung cancer lower at teaching hospitals 2
(Date:5/5/2015)... SUNNYVALE, Calif. , May 5, 2015  Accuray ... scheduled to present at the Bank of America Merrill ... on Tuesday, May 12, 2015 at 2:20pm ... presentation will be available on the Investor Relations page ... webcast replay of the presentation will begin approximately one ...
(Date:5/5/2015)... , May 5, 2015  Image Stream Medical, a ... agreement with MedAssets, one of the largest group purchasing ... United States.  Under terms of the three-year agreement, Image ... services will be made available to MedAssets members beginning ... partnership, Image Stream Medical CEO Eddie Mitchell ...
(Date:5/5/2015)... , May 05, 2015 Research and ... the addition of the "Clinical Laboratory,Molecular Diagnostics ... 2015 to 2019 - Latin America, Africa and ... A market that just keeps on ... benefit from the explosion in biotechnology, especially genomics. ...
Breaking Medicine Technology:Image Stream Medical Announces Agreement with MedAssets 2Latin America, Africa and Middle East Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2
... VEGAS, June 28, 2011 The pharmacy made the decision ... of its customers. The fact Xpressdelivery.com offered cheapest Viagra ... of the world, and their desire to see more drugs ... was only logical. After giving the matter most careful consideration ...
... June 28, 2011 In strong collaboration with clinical ... compact version of the LokomatPro that offers greater system ... device in 2001, the LokomatPro has established itself as ... patients with neurological diseases and injuries resulting in gait ...
Cached Medicine Technology:Xpressdelivery.com Expanded Its Drug List Adding Most Demanded Generic Medications 2Hocoma Launches New Version of its Established Gait Training Device LokomatPro 2
... Analyzer (PCA) is used in conjunction ... a variety of parameters in whole ... 50 patient records and permits on-screen ... as transmission of records to a ...
... images and patient information from all ... in one central system. It simplifies ... cost-effectiveness so that healthcare professionals can ... helping people., ,Many Sources, One Solution ...
... The Attain 4194 Bipolar over-the-wire left-heart lead ... This new steroid-eluting lead has an angled ... a guidewire or a stylet delivery method, ... maneuver and position the lead in a ...
... Our Maxenon Xi300 is so bright many ... have higher gears to shift into when the ... features such as a true Hot Start and ... 300-watt xenon system that prevent failed start ups ...
Medicine Products: