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Researchers uncover approach for possibly eradicating HIV infection
Date:6/21/2009

the body. In-effect, HIV uses the body's own defense system as a hideout.

The research team was also successful in identifying how these HIV-infected memory T-cells replenish themselves. When populating T-cells, HIV does not replicate itself as it does in other cell types on the body. Instead, HIV persists in memory T-cells through cell division a finding that holds significant implications for possibly stopping the disease.

"Based on this research, we believe one possible method for eliminating HIV in the body is to use a combined approach," said Dr. Skaly. "We propose the use of medications that target viral replication of HIV throughout the body, in combination with drugs that prevent infected memory T-cells from dividing. We believe that by attacking the disease in these distinct two ways at once for an extended period of time, we can eliminate the reservoirs of HIV that currently persist within the human body, leaving an individual disease-free."

The next step for researchers is to begin testing their proposed treatment method using animal models and newly developed therapies.

"While this is a preliminary finding, we are hopeful that this research discovery will guide us in eradicating HIV infection in the body," said Dr. Skaly.


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Contact: Danielle Visconte
visconte@ohsu.edu
772-345-4782
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

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