Navigation Links
Researchers uncover approach for possibly eradicating HIV infection
Date:6/21/2009

ST. LUCIE, FL Researchers from the newly-established VGTI Florida and the University of Montreal have uncovered a possible method for eradicating HIV infection in the human body. The researchers have also revealed new information which demonstrates how HIV persists in the body - even in patients receiving drug treatments - and how the virus continues to replicate itself in individuals undergoing treatment. The research findings will be published in the online version of the journal Nature Medicine on June 21 and will be featured in an upcoming print edition of the journal.

Medical advancements in the past 20 years have significantly increased the survival rates of AIDS patients. In fact, approximately 90 percent of patients infected with AIDS can survive with the disease as long as they are treated with a complex series of antiretroviral drugs.

"Current medications allow us to control HIV and limit its progression in most cases," explained Rafick-Pierre Skaly, Ph.D., current scientific director for VGTI Florida, a former scientist at the University of Montreal, and senior author of the research paper. "However, the medications do not eradicate the disease. Instead, the disease persists within the body much like water in a reservoir - and is never fully destroyed. We believe our latest research may help scientists and physicians overcome this hurdle."

The research team was able to identify a possible new way of attacking HIV by first identifying the specific cells where HIV infection persists in patients currently undergoing treatment. They found that the disease is able to survive within two subsets of memory T-cells. Memory T-cells are a portion of the body's immune system and have the ability to learn, detect and attack certain types of infectious diseases.

By infecting cells within the body's own immune system, HIV is able to avoid antiviral treatments that are effective in stopping HIV in other cell types in the body. In-effect, HIV uses the body's own defense system as a hideout.

The research team was also successful in identifying how these HIV-infected memory T-cells replenish themselves. When populating T-cells, HIV does not replicate itself as it does in other cell types on the body. Instead, HIV persists in memory T-cells through cell division a finding that holds significant implications for possibly stopping the disease.

"Based on this research, we believe one possible method for eliminating HIV in the body is to use a combined approach," said Dr. Skaly. "We propose the use of medications that target viral replication of HIV throughout the body, in combination with drugs that prevent infected memory T-cells from dividing. We believe that by attacking the disease in these distinct two ways at once for an extended period of time, we can eliminate the reservoirs of HIV that currently persist within the human body, leaving an individual disease-free."

The next step for researchers is to begin testing their proposed treatment method using animal models and newly developed therapies.

"While this is a preliminary finding, we are hopeful that this research discovery will guide us in eradicating HIV infection in the body," said Dr. Skaly.


'/>"/>

Contact: Danielle Visconte
visconte@ohsu.edu
772-345-4782
Oregon Health & Science University
Source:Eurekalert

Related medicine news :

1. UGA researchers achieve breakthrough in effort to develop tiny biological fuel cells
2. Mayo researchers: Dramatic outcomes in prostate cancer study
3. Researchers compare different systems of measuring treatment intensity in hypertension care
4. Jackson, Rockefeller obesity researchers share Shaw Prize
5. TGen and USC researchers find genetic markers to help fight diabetes
6. Vanderbilt researchers pioneer an advanced sepsis detection and management system
7. USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma
8. Researchers identify 4 new targets for breast cancer
9. Researchers at Case Western Reserve discover a new way the body fights fungal infection
10. Off-label morning sickness drug deemed safe for fetuses -- Ben-Gurion U. researchers
11. Researchers identify four new targets for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... Santa Clara, Calif. (PRWEB) , ... May 26, ... ... technology, announces the integration of the CareFusion NOX-T3 portable sleep monitor with its ... that provides a consistent, browser-based interface for diagnostic device operations. With this platform, ...
(Date:5/26/2017)... , ... May 26, 2017 , ... After raising nearly ... Top gadget will continue to be available at a discounted crowdfunding price on ... stress wherever they are, I also wanted to bring a fidget toy to the ...
(Date:5/26/2017)... ... May 26, 2017 , ... “When the Stars Lead ... is the creation of published author Laura Weigel Douglas, an avid reader who lives ... a house that sometimes feels like Green Hills Adventure Camp. She couldn’t be more ...
(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of ... District had left education officials with a number of critical issues to address before ... had to be accomplished with little or no disruption to class schedules. Second, the ...
(Date:5/24/2017)... San Diego, California (PRWEB) , ... May 24, ... ... patient care through innovative medical image management and interpretation, has received U.S. Food ... technology. , Nucleus.io is a web-based, scalable and secure cloud platform for ...
Breaking Medicine News(10 mins):
(Date:5/11/2017)... 11, 2017  Thornhill Research Inc. ( ... an $8,049,024 USD five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery contract by ... Commercial Corporation (CCC) ( Ottawa, Ontario, Canada ... administer general anesthesia to patients requiring emergency medical ... US Marine Corps have been a longtime partner ...
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)... , May 9, 2017  Oramed Pharmaceuticals Inc. ... a clinical-stage pharmaceutical company focused on the development ... the Canadian Intellectual Property Office has granted Oramed ... Administration of Exenatide". The patent covers Oramed,s invention ... GLP-1 is an incretin hormone that stimulates ...
Breaking Medicine Technology: