Navigation Links
Researchers train the immune system to deliver virus that destroys cancer in lab models
Date:12/18/2007

s back into the mouse. Researchers found that once the T-cells returned to the lymph nodes and spleen, the virus detached itself from the T-cells, found the tumor cells, selectively replicated within them and extracted tumor cells from those areas.

CANCER VACCINE

The procedure used in this study triggered an immune response to cancer cells, which means that it could be used as a cancer vaccine to prevent recurrence.

We show that if you kill tumor cells directly in the tumor itself, you can get a weak immunity against the tumor, but if you use this virus to kill tumor cells in the lymph nodes, you get a higher immunity against the tumor, Dr. Vile says.

RESULTS

The technique used in this study successfully treated the cells of three different diseases: melanoma, lung cancer and colorectal cancer. The results include:

  • Two days after treatment, the presence of melanoma tumor cells in lymph nodes was significantly less, but not completely gone. There were no cancer cells in the spleen.

  • Ten-to-14 days after a T-cell transfer, both the lymph nodes and spleen were free of melanoma tumor cells.

  • Mice treated with a single dose of the T-cells transfer developed a potent T-cell response against melanoma tumor cells.

  • Although the procedure was not intended to treat the primary melanoma tumor, significant reductions in tumor cells were observed.

  • In mice with lung cancer metastasis, cancer cells were significantly reduced in one-third of mice and completely eradicated in two-thirds of mice. Efforts to clear metastases from colorectal tumors were similarly effective.

  • Lung and colorectal tumor cells were purged from lymph nodes. Also, the spleens of mice that had lung cancer developed immunity to the cancer after the treatment.

The technology already exists to extract T-cells from patie
'/>"/>

Contact: Amy Reyes
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... The Institute for Integrative Nutrition ... to announce its new partnership with California ... university offering graduate programs featuring flexible learning. Graduates ... now eligible to receive six graduate credits towards ... , “I’m so thrilled to announce this new ...
(Date:8/20/2014)... "I decided that there needed to be ... manner without the hassles associated with using conventional oral ... patent-pending DR. GATES ORAL-HYGIENE TOOL provides an easy way ... good oral hygiene and fresh breath, and it eliminates ... affordable, eco-friendly and easy to use, the device is ...
(Date:8/20/2014)... acellular allogeneic nerve, from which Schwann cells, ... removed, reduced postoperative immune rejection. Simultaneously, chemically ... and base materials, such as the bottom ... a good scaffold in the process of ... similar to autologous nerve transplantation, can guide ...
(Date:8/20/2014)... 20, 2014 Doctors at the University of ... out mesothelioma in laboratory mice by injecting them with a ... details of the study on its website. Click here ... Hong Kong University’s AIDS Institute of Microbiology created a vaccine ... PD-1. By altering DNA, the vaccine is designed to prevent ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Attendees of ... a sneak peak at Los Angeles’ first multi-faceted food ... tour of a blossoming 1.5-acre high school campus urban ... shipping container farm in the L.A. Art District. , ... of sustainable urban agriculture, will kick off Seedstock’s “Reintegrating ...
Breaking Medicine News(10 mins):Health News:Integrative Nutrition Announces New Partnership with California Institute of Integral Studies 2Health News:Integrative Nutrition Announces New Partnership with California Institute of Integral Studies 3Health News:New Research Study Finds Vaccine Stops Mesothelioma in Lab Mice, According to Surviving Mesothelioma Website 2Health News:Seedstock Sustainable Agriculture Conference’s Urban Farm Field Trip to Offer First Look at Los Angeles’ Premier Food Business Incubator 2Health News:Seedstock Sustainable Agriculture Conference’s Urban Farm Field Trip to Offer First Look at Los Angeles’ Premier Food Business Incubator 3
... to minimize risk, experts say , TUESDAY, Jan. 19 (HealthDay ... such as heart disease, high blood pressure and diabetes, to ... challenge for an anesthesiologist to care for during surgery. , ... Dr. Kumar Belani, a professor of anesthesiology at the University ...
... causes problems similar to MS in humans, findings show ... in a gene called ZFP191 causes central nervous system ... occurs in humans with multiple sclerosis, new research has ... body attacks and destroys the myelin sheath that insulates ...
... The ... sclerosis) announced today that it has appointed Gordon S. LaVigne as chief development and ... ... , the nation’s leader in the fight against the disease ALS (amyotrophic laterals sclerosis) ...
... 11 A.M. , Justin Herman Plaza ... , www.walkforlifewc.c o m , Speakers and ... Jan. 19 A woman who walked away from her job as a ... a group intent on exposing abuses in the abortion industry will speak at the ...
... , PORT-AU-PRINCE, Haiti , ... Oxfam is working to overcome the challenges of delivering aid ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080221/DC14723LOGO ) , Although aid is beginning ... Haitian and international staff, the logistical challenges combined with a ...
... , JACKSONVILLE, Fla. and ... Medicine, Inc. ( www.USPreventiveMedicine.com ) will partner with the Iowa Chronic ... members not yet eligible for Medicare reduce health risks and live ... in equal amounts by a grant/cooperative agreement from the Centers for ...
Cached Medicine News:Health News:Excess Weight Poses Anesthesia Challenge 2Health News:Excess Weight Poses Anesthesia Challenge 3Health News:Gordon S. LaVigne Appointed ALS Association Chief Development and Communications Officer , 2Health News:Gordon S. LaVigne Appointed ALS Association Chief Development and Communications Officer , 3Health News:6th Annual Walk for Life West Coast Saturday, January 23, 2010 2Health News:Haiti Earthquake: One Week Later, Aid Agencies Facing Challenges 2Health News:Iowa Farm Bureau Introduces Bold Initiative to Improve Health Care for Rural Iowans 2Health News:Iowa Farm Bureau Introduces Bold Initiative to Improve Health Care for Rural Iowans 3Health News:Iowa Farm Bureau Introduces Bold Initiative to Improve Health Care for Rural Iowans 4
(Date:8/20/2014)... 2014   Ventana Medical Systems, Inc.  (Ventana), ... that its VENTANA System for Primary Diagnosis 1 ... Union for routine pathology, including primary diagnosis with ... Virtuoso software coupled with either the VENTANA iScan ... provides automated digital slide creation, case management and ...
(Date:8/20/2014)... BURLINGTON, Mass. , Aug. 20, 2014 ... Japanese electrophysiology (EP) mapping and ablation device ... increasingly use ablation to treat atrial fibrillation ... a primary treatment option for AF will ... for this application, such as advanced loop ...
(Date:8/20/2014)... 2014  Amerigen Pharmaceuticals Ltd. announces that its ... received Chinese FDA (CFDA) approval and has subsequently ... the China domestic market.  ... agreement with Sinochem Jiangsu Pharmaceutical Co., Ltd., Amerigen ... approved and China CFDA certified oral solid dose ...
Breaking Medicine Technology:Full digitization of the anatomic pathology lab is here with the VENTANA System for Primary Diagnosis 2Full digitization of the anatomic pathology lab is here with the VENTANA System for Primary Diagnosis 3Electrophysiology Mapping and Ablation Device Market in Japan to Reach $1.1 Billion by 2023 2Electrophysiology Mapping and Ablation Device Market in Japan to Reach $1.1 Billion by 2023 3Amerigen Pharmaceuticals Ltd. announces that its Chinese subsidiary, Suzhou Amerigen Pharmaceuticals Co. Ltd., has received Chinese FDA (CFDA) approval and has subsequently launched its generic Mecobalamin 0.5 mg Tablets into the China domestic mark 2
... Sequenom, Inc. (Nasdaq: SQNM ) today announced ... company at the following conferences in November. ... ) Lazard Capital Markets 7th Annual ... York, NY Presentation date: Tuesday November 16, 2010 ...
... Pharmaceuticals today announced it has discovered that EVP-6124, its ... not previously seen in the scientific community: it acts ... By acting as a co-agonist and sensitizing ... amounts of naturally occurring ACh, typically found in individuals ...
Cached Medicine Technology:Sequenom to Present at Two Financial Conferences in November 2EnVivo Pharmaceuticals Research Shows EVP-6124 Acts as Acetylcholine Co-Agonist 2EnVivo Pharmaceuticals Research Shows EVP-6124 Acts as Acetylcholine Co-Agonist 3
Stylish yet conservative, these classics are reliable, comfortable and durable....
Safilo Design, a state-of-the art ophthalmic collection that blends technology with minimalist sophistication. Each style comes with a sleek silver-colored hard case with magnetic closure....
Inquire...
Classic, stylish, and preppy, this collection features men's, women's and unisex styles....
Medicine Products: