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Researchers to use novel metabolomics technology for COPD
Date:7/16/2012

ng mucus and any inhaled pathogens, such as bacteria, up and out of the lungs to prevent infection.

"Ciliopathy occurs long before there are any clinical signs of smoking-induced COPD. However, the underlying genesis of smoking-induced airway ciliopathy is unknown," says Dr. Steven S. Gross, co-principal investigator of the study and professor of pharmacology and director of the Mass Spectrometry Facility at Weill Cornell. "The goal of our study is to fill this knowledge gap and identify what exactly drives ciliopathy in smokers with COPD."

The researchers hypothesize that ciliopathy is linked to the oxidant stress placed on airway epithelium cells by cigarette smoke and that smoking-induced COPD is associated with altered metabolism in lung tissue and serum. Researchers believe the profiling of metabolites in the biofluids of COPD patients will provide fundamental insight into the underlying molecular mechanisms of ciliopathy development and the pathogenesis of COPD.

"A biomarker for COPD would be useful to identify smokers that will develop COPD," says Dr. Crystal. "Success of this study would be a major step in developing new approaches for the screening and treatment of COPD patients."

In the study, Weill Cornell researchers will for the first time use metabolomics to broadly identify, analyze and profile abnormal changes in cell metabolism and metabolites for COPD in the airway of epithelial cells in the lungs. Using the latest state-of-the-art mass spectrometry based technology to assist in global metabolite profiling of lung serum and tissue samples of COPD patients, researchers will examine thousands of small molecules and measure changes in metabolite expression. Cell metabolism is the set of chemical reactions that occur inside the cell and metabolites are their small molecule products that participate in all aspects of cellular function.

"The use of metabolomics is a powerful new approach to discover how a
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Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Columbia University Medical Center
Source:Eurekalert

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