Navigation Links
Researchers to use novel metabolomics technology for COPD

NEW YORK (July 12, 2012) -- at Weill Cornell Medical College were awarded a $6.5 million grant from the National Heart, Lung, and Blood Institute for a five-year investigation into metabolic changes occurring within airway epithelial cells in the lungs of chronic obstructive pulmonary disease (COPD) patients caused by cigarette smoking. In addition, researchers aim to identify which cigarette smokers are at highest risk of developing COPD as well as novel biomarkers to assist in the development of new therapeutic treatments for the disease.

One-fifth of the adult population in the United States smokes cigarettes, and each puff can burden the human lungs with a hundred trillion oxidants and more than 4000 chemical compounds. Cigarette smoking is a major cause of disease, including COPD, the fourth leading cause of death of Americans. There is currently no cure, no effective treatments beyond oxygen therapy and no biomarkers to diagnose the disease early.

"Twenty percent of smokers get COPD, so it is vital that we identify who is at the highest risk and why," says Dr. Ronald G. Crystal, co-principal investigator for the study and chairman of genetic medicine at Weill Cornell Medical College. "Gaining a better understanding of COPD's underlying biology and the metabolic changes forced by cigarette smoke to airway epithelial cells will help us effectively deal with this major health problem. We can use this information to develop new ways to protect the lungs."

Smoking-induced COPD patients can experience shortness of breath and loss of lung function due to the severe narrowing of their lung airways. COPD is associated with the progression of "ciliopathy," the cellular dysfunction within the airway epithelial cells that leads to the shortening of cilia cells, mucus accumulation and the impairment of infection defenses. The majority of epithelial cells are made up of cilia, important cells in lung health that play the crucial role of moving mucus and any inhaled pathogens, such as bacteria, up and out of the lungs to prevent infection.

"Ciliopathy occurs long before there are any clinical signs of smoking-induced COPD. However, the underlying genesis of smoking-induced airway ciliopathy is unknown," says Dr. Steven S. Gross, co-principal investigator of the study and professor of pharmacology and director of the Mass Spectrometry Facility at Weill Cornell. "The goal of our study is to fill this knowledge gap and identify what exactly drives ciliopathy in smokers with COPD."

The researchers hypothesize that ciliopathy is linked to the oxidant stress placed on airway epithelium cells by cigarette smoke and that smoking-induced COPD is associated with altered metabolism in lung tissue and serum. Researchers believe the profiling of metabolites in the biofluids of COPD patients will provide fundamental insight into the underlying molecular mechanisms of ciliopathy development and the pathogenesis of COPD.

"A biomarker for COPD would be useful to identify smokers that will develop COPD," says Dr. Crystal. "Success of this study would be a major step in developing new approaches for the screening and treatment of COPD patients."

In the study, Weill Cornell researchers will for the first time use metabolomics to broadly identify, analyze and profile abnormal changes in cell metabolism and metabolites for COPD in the airway of epithelial cells in the lungs. Using the latest state-of-the-art mass spectrometry based technology to assist in global metabolite profiling of lung serum and tissue samples of COPD patients, researchers will examine thousands of small molecules and measure changes in metabolite expression. Cell metabolism is the set of chemical reactions that occur inside the cell and metabolites are their small molecule products that participate in all aspects of cellular function.

"The use of metabolomics is a powerful new approach to discover how airway epithelial cells are disturbed by smoking and how this may lead to COPD," says Dr. Gross. "Global metabolite profiling represents an untapped route for defining which biochemical pathways are specifically altered in smokers with COPD."

In addition, researchers will combine metabolic profiling with in vitro studies of human subjects and murine airway epithelium. Serum, lung epithelial lining fluid and airway epithelium samples from human research subjects, as well as an extensive cohort of banked human clinical trial samples, will be analyzed and compared from a population of nonsmokers, smokers, COPD smokers and smokers with and without COPD that underwent smoking cessation.

The study is a collaboration between Weill Cornell and Cold Spring Harbor Laboratory. Other study investigators include: Dr. Yuliang Ma, Dr. Jason G. Mezey, Dr. Matthew Walters from Weill Cornell; and Dr. Grigori N. Enikolopov and Dr. Natalia Peunova from Cold Spring Harbor.

Weill Cornell's new award is part of a larger grant awarded to five institutions chosen to receive funding from the National Institutes of Health (NIH) to study the abnormal metabolism of cardiovascular and lung diseases. The five partnering institutions include: Washington University, Cleveland Clinic, Emory University, National Jewish Health and Weill Cornell. Washington University will serve as the coordinating center for the research program. The researchers from the five institutions will work together and with the NIH to inform new approaches and new ideas in each other's studies.


Contact: Lauren Woods
New York- Presbyterian Hospital/Columbia University Medical Center

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... The American Association of ... local poison centers through donations on Tuesday, Dec. 1, 2015. Since 2012, the ... that inspires people to collaborate in improving their local communities and help give ...
(Date:11/24/2015)... R.I. (PRWEB) , ... November 24, 2015 , ... With ... Amica Insurance is sharing safety tips to help protect your family and vehicle. , ... crashes around the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips ...
(Date:11/24/2015)... ... 2015 , ... Abington Hospital – Jefferson Health is pleased ... Surgery Facility for treating individuals living with morbid or extreme obesity. , Aetna ... its members to help them make informed decisions about their healthcare needs. In ...
(Date:11/24/2015)... M.D. (PRWEB) , ... November 24, 2015 , ... ... new award for its exceptional customer service: the TrustDale certification. The award recognizes ... The Baltimore stone honing , tile and grout, and hard surface restoration ...
(Date:11/24/2015)... New York, N.Y. (PRWEB) , ... November 24, 2015 , ... ... in Giving Tuesday, the global movement driven by social media and the generosity of ... Autism Speaks, then encourage their social media networks to give – and share the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... st  Scientific Assembly and Annual Meeting of the Radiological ... in Chicago on Nov-29 th through ... st  Scientific Assembly and Annual Meeting of the Radiological Society of ... Chicago on Nov-29 th through Dec-4 th ... will present its revolutionary whole body CZT digital SPECT/CT solution at ...
(Date:11/24/2015)... 2015 Teledyne DALSA , a Teledyne Technologies ... will introduce its CMOS X-Ray detector for mammography ... to December 3, at McCormick Place in Chicago ... and interventional imaging will be on display in the South ... advanced CMOS X-Ray detectors is the industry benchmark for high ...
(Date:11/24/2015)...  Boston Scientific Corporation (NYSE: BSX ) is ... Conference on December 8, in New York ... president, Investor Relations, will participate in a 30-minute question-and-answer ... a.m. ET. --> Susie Lisa , vice ... session with the host analyst beginning at approximately 8:35 ...
Breaking Medicine Technology: