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Researchers to develop next generation immunotherapy for children with deadly solid tumors
Date:4/3/2013

en with neuroblastoma and is estimated to open before the end of the year. Stephan Grupp, M.D., Ph.D., Professor of Pediatrics at the Children's Hospital of Philadelphia, will direct the trial in collaboration with Michael Pulsipher, M.D., Professor of Pediatrics at the Primary Children's Medical Center/University of Utah, and Carl June, M.D., the Director of Translational Research at the Abramson Cancer Center at the University of Pennsylvania, who led the altered T-cell/HIV study.

Today, children with relapsed high-risk neuroblastoma have little or no options to cure their disease through traditional methods, including chemotherapy, surgery and radiation. Early clinical studies utilizing cancer immunotherapies such as modified T-cells have demonstrated initial success and promising potential as more effective treatment options in some blood cancers, including chronic myelogenous leukemia in adults and acute lymphoblastic leukemia in children.

"The ACT FAST initiative aims to bring the newest engineered T cell therapies to pediatric solid tumors. The ACT FAST approach is rigorous, highly focused and intensely translational. By collaborating with pediatric physician-scientists across institutions through ACT FAST, we will not only be able to advance research into engineered T-cell treatments, but just as importantly, offer cutting-edge cancer immunotherapy clinical trial options rapidly to children whose cancer recurs or resists current treatment," said Dr. Grupp.


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Contact: Jenny Song
jenny@solvingkidscancer.org
212-588-6625
Solving Kids' Cancer
Source:Eurekalert

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