Navigation Links
Researchers target HER1 receptor for peptide cancer vaccine, therapeutic agents
Date:7/24/2013

COLUMBUS, Ohio -- Small proteins called peptides that consist of 10 to 50 amino acids are being studied as cancer vaccines and as possibly safer, more effective and less costly alternatives to the monoclonal-antibody-based drugs and small-molecule inhibitors now used to treat many malignancies.

Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) have identified two regions on the HER1/EGFR receptor, a protein important for cancer-cell growth and metastasis and for poor patient survival, as targets for peptide agents.

The receptor molecule protrudes from the surface of cancer cells in abnormally high numbers. It is activated by growth factors in the blood and released by other cells in the tumor, stimulating tumor growth.

"Our findings could lead to novel peptide vaccines and mimetic inhibitors that target HER1 in tumors of the breast, lung, colon and head and neck, and that overcome many of the significant shortcomings of antibody-based drugs such as cetuximab," says principal investigator Pravin Kaumaya, PhD, director of the division of vaccine development at the OSUCCC - James.

"Such peptide agents might enable the development of combination immunotherapies using either HER2 vaccines or VEGF therapy that avoid the mechanisms of resistance or secondary treatment failures sometimes experienced with antibody treatment," says Kaumaya, who is also professor of obstetrics and gynecology, of molecular and cellular biochemistry, and of microbiology at Ohio State.

The study is published in the Journal of Immunology.

HER1 is a member of the epithelial growth factor (EGF) family of cell-surface receptors, which includes the HER2 receptor. These receptors play a central role in the development of a variety of human cancers, including certain breast cancers, lung cancer, colorectal and head and neck cancers.

Kaumaya and his colleagues evaluated three sequences of peptides to determine which were the most specific and immunogenic (i.e., raised the strongest immune response in test animals), and therefore were best suited for use as vaccines or therapeutics. The three sequences, or epitopes, were based on the site of contact between HER1 and the growth factor that normally binds with it, epithelial growth factor (EGF). Key technical findings included:

  • Two of the sequences (382-410 and 418-435) were identified as best for use as cancer therapy or a cancer vaccine;
  • The 382-410 epitope overlaps the binding site of cetuximab, an antibody agent that inhibits HER1 binding; however, the 418-435 epitope significantly inhibited tumor growth in transplantable breast and lung cancer models;
  • The vaccine constructs were highly immunogenic and established immunological memory in a rabbit model. "Overall," Kaumaya says, "our results show that the 418-435 epitope has great potential for use as a vaccine or treatment option for HER1-expressing cancers."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. University of Hawaii Cancer Center researchers report
2. Mount Sinai researchers discover mechanism behind development of autoimmune hepatitis
3. Dead gene comes to life, puts chill on inflammation, Stanford researchers find
4. Researchers identify 146 contemporary medical practices offering no net benefits
5. Protein complex linked to cancer growth may also help fight tumors, Moffitt researchers say
6. Disney researchers use encoded audio signals to provide second screen experiences at most venues
7. Researchers Discover a Gene That Is Associated with Obesity
8. Researchers report a complete description of gene expression in the human retina
9. Researchers Find That Setting Weight Loss Ranges Are More Beneficial than Specifics, Making Weight Loss Via Supplements Like Prescopodene More Likely
10. Single dose of ADHD drug can reduce fall risk in older adults -- Ben-Gurion U researchers
11. UCLA researchers find link between intestinal bacteria and white blood cell cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... Backed by decades of ... each job, ensuring the best suited solution to meet regulatory requirements. Their professional ... their lab in Istanbul. , Metroloji Okulu specializes in MadgeTech’s line of medical ...
(Date:5/24/2016)... ... May 24, 2016 , ... Eggsurance, the first ... relaunch of its community and education hub for women considering fertility preservation, as ... create a safe and welcoming place for women to find cycle buddies, get ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... advancing the science and clinical practice of radiosurgery, is recognizing five medical residents ... radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). The awards will be presented at ...
(Date:5/24/2016)... ... May 24, 2016 , ... The ... 9.3 million people, or 10% over last year, according to data in the ... group policies was comparatively stable, with a slight decrease in risk-based groups and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Bio-Logic ... specialist for forty years and a trainer for Ageless Grace ( http://www.agelessgrace.com ) ... Talk Show on May 16, 2016. , Formerly a Northwestern University Literature Professor, ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 ... for the treatment of cancer and orphan genetic diseases, ... up to $4.4 million from the Israel Innovation Authority ... Israeli Ministry of Economy and Industry. The mission of ... entrepreneurship in various industries, including science and technology, while ...
(Date:5/23/2016)... May 23, 2016   Purdue Pharma L.P. ... an agreement with Egalet Corporation and Acura Pharmaceuticals, ... part of the agreement the companies will exchange ... all three companies to develop and sell several ... "This agreement reflects the commitment of Purdue Pharma ...
(Date:5/20/2016)... , May 20, 2016 ... 2016 to Medical Devices of its online business ... survey on the current state of the Titrator ... the industry like definitions, classifications, Specifications, applications and ... manufacturing process like Raw Material Suppliers, Equipment Suppliers, ...
Breaking Medicine Technology: