Navigation Links
Researchers suggest new paradigm for breast cancer screening

Washington, DC -- Should we spend more money urging women to use mammography screening on a regular basis or should those dollars and effort be used for discovering and developing better early detection tests?

In an editorial published online June 29 in issue 14 of the Journal of the National Cancer Institute (JNCI), Jeanne S. Mandelblatt, MD, MPH, of the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center in Washington, DC, and Diana S.M. Buist, PhD, MPH of Group Health Research Institute in Seattle, suggest the latter, pointing to the limitations of mammography and calling it an "imperfect technology."

Their editorial accompanies a review and meta-analysis by Sally W. Vernon, MD, and colleagues of the effectiveness of intervention strategies such as educational outreach, counseling and simple reminders to encourage women to get repeat mammograms. In their editorial, Mandelblatt and Buist call the results "sobering" because behavioral interventions appear to only increase repeat screening rates by a small or moderate amount with insufficient evidence to know which approaches are the most effective.

"These results are all the more discouraging since the reviewed studies focused on getting women to undergo only one to two repeat screening examinations, not the 12 to 13 presently recommended for average risk women biennially from age 50 to 74," they write.

The reasons why interventions fail could be because "women are making an informed choice not to use an imperfect technology" the authors write. They point to media attention highlighting the fact that mammograms miss many cancers while detecting lesions that are false positives or ones that are never destined to become cancer.

Noting studies that suggest women with an increased risk of developing breast cancer have greater adherence to routine screening, the authors say interventions might be more effective in such subgroups, though this was not examined by the meta-analysis.

Mandelblatt and Buist also support the use of modeling to help understand the various factors that impact screening. Specifically, they highlight the work of the NCI-funded Cancer Intervention and Surveillance Modeling Network (CISNET) as an excellent example of the application of modeling to determine the most profitable avenues for intervention. Mandelblatt and others from CISNET are collaborating with Buist and her colleagues from the Breast Cancer Surveillance Consortium on modeling research to examine how risk level affects choice of screening modality and optimal ages of use.

Still, the authors offer a strong recommendation in order to realize the promise of eliminating the burden of cancer. "It could be reasonably argued that we should better spend our efforts in discovering better early detection tests.

"New paradigms guided by evidence from modeling, novel trials and new scientific discovery will be needed."


Contact: Karen Mallet
Georgetown University Medical Center

Related medicine news :

1. Of lice and man: Researchers sequence human body louse genome
2. AcademyHealth honors leading health services researchers
3. UCLA researchers, US military collaborate to open center for traumatic brain injury
4. UCSD researchers receive $2.5 million in new stem cell grants
5. Researchers find key to getting estrogens benefits without cancer risk
6. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
7. WSU researchers find mothers of children with autism pay price in workplace
8. Free Resources from EBSCO Publishing Providing Useful Information to Researchers
9. University of Utah researchers fight genetic killer of infants and toddlers
10. Researchers identify key enzyme in melanoma cell development
11. Researchers predict human visual attention using computer intelligence for the first time
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert ... Organizations, One Beat ” campaign. The partnership between the two groups began in 2014 ... MAP International’s cause. , MAP International was founded in 1954 and is an international ...
(Date:11/25/2015)... ... ... On November 25, 2015, officials of Narconon Arrowhead , the drug rehabilitation ... new cutting edge recovery program that has been 50 years in the making. ... with the purpose to free addicts from the symptoms and negative behaviors of addiction. ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study conducted by an ... IL, UV Angel is evaluating the efficacy of its product and its disinfection protocol. ... 30 beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical ...
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
(Date:11/25/2015)...  Today AVACEN Medical announced the issue of United States patent No. ... ". This patent shields the company,s AVACEN 100 dry heat therapy medical device and specific methods ... Photo - ... ... ...
(Date:11/25/2015)... , Nov. 25, 2015 USP 800 ... drug preparations (e.g. pharmacists, pharmacy technicians, nurses, physicians, ... technicians). The chapter also covers all entities which ... pharmacies, hospitals, other healthcare institutions, patient treatment clinics, ... --> --> What is ...
Breaking Medicine Technology: