Navigation Links
Researchers study potential health benefits of natural chemicals in muscadine grape seeds
Date:10/24/2007

WINSTON-SALEM, N.C. Could some of the natural chemicals found in plants be powerful enough to improve cardiovascular health" Researchers at Wake Forest University Baptist Medical Center are conducting the first-ever clinical study to evaluate the potential cardiovascular health effects of Natures Pearl Muscadine Grape Seed Supplement.

The scientists are evaluating the influence of this supplement on blood vessel function in 50 participants who have cardiovascular disease or are at high risk for developing it. Theyll also determine whether there are effects on cholesterol and other fats in the blood, blood sugar levels and vessel inflammation, which are all associated with increased risk of cardiovascular disease.

Natures Pearl is prepared in a way that generates a high concentration of plant chemicals, including gallic acid, ellagic acid, oligomeric proanthocyanidins (OPCs) and resveratrol. These are known to be antioxidants, or nutrients that can prevent or slow the oxidative damage to the body. The role of oxidative stress in blood vessel disease has generated interest in dietary sources of antioxidants, including black and green tea, grape seeds, olive oil and cocoa.

Muscadine grapes have been shown to be more potent in antioxidants than any other variety of grapes, and laboratory studies have suggested that grape seeds have higher antioxidant capacity than grape skins. Studies in humans have shown improved antioxidant capacity when grape seed supplement is added to the diet, as well as improvements in blood vessel function. However, the studies did not specifically include muscadine grapes, which have extremely high levels of antioxidant and anti-inflammatory compounds when compared to other fruits.

The goal of the current study is to determine if daily doses of the Natures Pearl supplement, which is specially prepared to maximize its natural antioxidant and anti-inflammatory concentrations, will have a favorable effect on cardiovascular risk factors, said David Herrington, M.D., M.P.H., lead investigator and a professor of cardiology.

Study participants are patients at Wake Forest Baptists Family Medicine and Internal Medicine practices and are between 18 years and 65 years old. For the first four weeks of the study, participants are randomly assigned to take either 1,300 mg. (two capsules) of the Natures Pearl Muscadine Grape Seed Supplement (grape seeds) daily or a placebo (inactive capsule).

For the next four weeks, participants do not take capsules to allow the product to wash out of their systems. Then, the groups will switch so that those who took placebo originally will take the supplement for four weeks.

Ultrasound technology is used to determine blood vessel function or reactivity. Blood flow in the brachial artery, the major vessel in the arm, is measured both before and after the arteries are constricted with a blood pressure cuff. In a healthy subject, the artery dilates after the constriction. Decreased reactivity is a sign of reduced artery function and is thought to be a precursor to atherosclerosis, the buildup of fatty deposits in the vessels that can lead to heart attack or stroke.

The test is used in the brachial arteries because the hearts arteries cannot be directly imaged with ultrasound. However, atherosclerosis is a disease that affects vessels throughout the body, and the test is considered a good indicator of overall vessel function.

The study will also measure any effects on total cholesterol, low-density lipoprotein or bad cholesterol, triglycerides, high-density lipoprotein or good cholesterol, blood sugar levels and markers for inflammation, such as C-reactive protein and interleukin-6.

Patients have been recruited and the results are expected to be analyzed in early 2008.

Cardiovascular disease is a significant problem in this country so it is worthwhile to examine foods that may have medicinal benefits, said Herrington. In this case, our goal is to determine whether the Natures Pearl supplement, which looks promising because of its extremely high antioxidant and anti-inflammatory content, will positively affect artery health.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers identify the early makers of Neonatal Sepsis
4. OHSU Researchers Announce New Discovery
5. Researchers Identify Gene Connected To Bipolar Disorder
6. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
7. Researchers trick Alzheimers Enzyme
8. Researchers find new HIV hiding place
9. Gene researchers make Malaria-resistant mosquito
10. New Hair in 15 Days Could Now Be A Possibility Say Researchers
11. Researchers developed world’s smallest toothbrus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 08, 2016 , ... A man who has struggled to quit smoking, a man who has ... determined to find solutions to his problems – and he did. Now Nabat, a serial ... to introduce his breakthrough inventions to the world and better people's lives. His own experience ...
(Date:2/8/2016)... Hilton Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... Head and surrounding areas with a vital new community enrichment program, has teamed up ... to local women and children suffering from intimate abuse. To support all those victimized ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... today that nominations will be accepted February 8, 2016 through May 8, ... Awards include the Information Security Executive® of the Year, which recognizes executives ...
(Date:2/8/2016)... ... February 08, 2016 , ... Discover the Rocky Mountain region’s longest ... and 700 companies. Attendees also get to see the most incredible gardens and ... Home Show , at the Colorado Convention Center - 700 14th St. Denver CO, ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... speaking on how healthcare companies can use newly released government data on populations ... a population and intervene and capture the value they create to succeed in ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 2016 The life of Dr. Jan Vilcek ... anything but ordinary.  Twists of fate, combined with sheer grit, ... the constraints of communist Czechoslovakia to New York ... on to make history by playing a key role in ... the world, Remicade.  Dr. Vilcek brings readers along his improbable ...
(Date:2/9/2016)... 2016 The new report "Global Anti-Bacterial Drugs Market Assessment ... Consulting group reveals that the North America ... 38.9% in 2014 that translated into revenues worth US$ 16,907.3 million. ... , Asia-Pacific , Latin America ... . The global anti-bacterial market is inclined towards ...
(Date:2/8/2016)... , Feb.8, 2016 Alzheimer Diagnostic ... Summary Medical Devices sector report , ... 2015" provides an overview of Alzheimer Diagnostic Tests ... comprehensive information on the pipeline products with comparative ... development. The report reviews major players involved in ...
Breaking Medicine Technology: