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Date:3/14/2008

arcinoma, said Stewart.

On March 14, Perry Shen, M.D. associate professor, section of surgical oncology, will report findings on the use of IPHC in patients with peritoneal cancer and hepatic metastases (HM), or liver cancer that has metastasized from colorectal cancer. The use of IPHC in patients with this presentation is controversial.

This was a retrospective study of 144 patients undergoing surgery to remove as much of the cancer as possible and IPHC between 1991 and 2007, said Shen. There were 17 patients with HM. Clinical and pathological information was obtained from a prospectively collected database and electronic medical record.

Median overall survival for patients with and without HM was 22.7 months and 15.8 months respectively, which was not a significant difference. Two- and four-year survival rates for the HM patients were 34.0 percent and 11.3 percent. Further analysis demonstrated the presence of malignant fluid in the abdominal cavity to be a significant predictor of decreased survival in patients with HM.

We concluded that patients with peritoneal carcinoma and hepatic metastases undergoing cytoreductive surgery and IPHC for colorectal cancer had no significant difference in overall survival compared to those without HM, said Shen. In select patients with peritoneal carcinoma and hepatic metastases, cytoreductive surgery and IPHC may have some benefit. Malignant ascites, an accumulation of fluid in the peritoneal cavity, predicted a poor outcome.


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Contact: Jonnie Rohrer
jrorher@wfubmc.edu
336-716-6972
Wake Forest University Baptist Medical Center
Source:Eurekalert

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