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Researchers study how chemicals in drugs and around us impact stem cells
Date:1/17/2012

tes the need for animals in the toxicology testing. The stem cells used in the study are human adult neural stem cells and adult mesenchymal stem cells (which are grown in our connective tissue). The work will provide a baseline of fundamental knowledge on how stem cells are impacted by the chemicals around us.

The ultimate goal of the research is to develop a high-throughput and inexpensive system that manufacturers can use to quickly screen thousands of chemicals for their effects on stem cells, according to Dordick.

"One of the goals would be that we would add a stem cell screening component to the safety testing of a pharmaceutical candidate or to the assessment of the health effect of a chemical in the environment, say on our food," he said. "This would give us a much broader understanding of how the human body will respond to these chemical compounds."

The work is an extension of Dordick's previous work conducted in a long-standing collaboration with Douglas Clark, the Warren and Katharine Schlinger Distinguished Professor and Chair, Department of Chemical and Biomolecular Engineering at the University of California, Berkeley. He is co-investigator in the current project, to develop inexpensive high-throughput toxicology tests and reduce the use of animals in such testing. Information on their previous research can be found here.

The grant is over a four-year period. Dordick, Schaffer, and Clark will be joined in the research by Robert Linhardt, Ann and John H. Broadbent Jr. '59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer.


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Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert

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