Navigation Links
Researchers solve first structure of a key to intact DNA inheritance
Date:12/20/2007

HOUSTON - Researchers have solved the structure of a DNA-protein complex that is crucial in the spread of antibiotic resistance among bacteria. Knowing this structure also provides fundamental insight into how cells successfully divide into two new cells with intact DNA

The report in the Dec. 20th issue of Nature focuses on how DNA separates and maintains its integrity when a cell divides. Using X-ray crystallography, the team led by structural biologists at The University of Texas M. D. Anderson, with colleagues at the University of Sydney, Australia, produced clear 3-D images of the structure that results when two proteins connect with a DNA site to "segregate" DNA during cell division.

"We solve structures to answer questions about how molecules carry out their biological functions. Without knowing the structure, you can't understand molecular mechanisms at a detailed level," says lead author Maria Schumacher, Ph.D., associate professor in M. D. Anderson's Department of Biochemistry and Molecular Biology.

In this case, Schumacher and colleagues answer a basic science question and flag a possible target for clinical attack on antibiotic-resistant Staphlococcus Aureas, a tenacious and often lethal staph infection.

"The plasmid segregation system we are working on, called pSK41, is found in S. aureus and confers resistance to multiple antibiotics, including the drug of last resort, vancomycin," Schumacher says. "Because the segregation systems are essential for the retention of these multidrug resistant plasmids, they represent wonderful drug targets."

Plasmids are additional strips or circles of DNA found in bacteria that provide the bacterium with some mechanism of defense - in this case, protection against antibiotics. Plasmids can be transferred from one type of bacteria to another through a number of mechanisms.

Plasmids are also a great model for understanding cell division and segregation, Schuma
'/>"/>

Contact: Scott Merville
smervil@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 2014 Today, the Diamond in the ... to be held, Sunday, October 19, 2014 at the ... annual awards show honors the dare-devil stuntwomen of film ... stars. Over 12 categories will be recognized in ... Mayne. , Special honors will be given to ...
(Date:9/16/2014)... 16, 2014 The Fertility Centers of ... Fairfax Egg Bank. The collaboration will give patients access ... egg offering at the Fertility Centers of New England. ... offers the nation’s largest selection of frozen donor eggs. ... reasons:, , The Donor is already ...
(Date:9/15/2014)... September 16, 2014 Club wear is provocative, ... a sensual atmosphere with a very relaxed dress code. There ... to clubs based on the location of the club, the ... club wear manufacturer and retailer, has delightedly pronounced its new ... offered at incredibly low prices. , A nightclub (also known ...
(Date:9/15/2014)... Web-based training targeted at college-aged men is an effective ... U.S. campuses, according to a researcher in the School ... RealConsent program reduced sexually violent behavior and increased the ... sexual assault, said Dr. Laura Salazar, associate professor of ... the paper, “A Web-Based Sexual Violence Bystander Intervention for ...
(Date:9/15/2014)... Authors Christine Snow and Donna Albury highlight the ... alcoholics. Born out of love and pain and the authors’ ... The Life... ” (published by Xlibris) reveals the struggles with ... the same fate. , Night life is popular among ... this. This book chronicles a typical night in the life ...
Breaking Medicine News(10 mins):Health News:Hollywood's Action Icon Awards to Honor Legendary Stuntwomen In A Star-Studded Gala and Awards Ceremony 2Health News:FCNE Announces Partnership with Fairfax Egg Bank 2Health News:Delicate Club Wears Are For Sale At Fecbek.com 2Health News:Study: Web Based Training Can Reduce Campus Rape 2Health News:Authors show perils of alcohol abuse in new graphic novel 2Health News:Authors show perils of alcohol abuse in new graphic novel 3
... researchers hope will cast a lifeline to HIV patients ... in long-awaited trials, The Lancet reports on Saturday. ... an alternative for patients who are resistant to a ... ,An international consortium of doctors has been ...
... pet turtle, while 22 other people were infected by the ... authorities said. ,The Centers for Disease Control and ... Friday reminding Americans of the health risks associated with small ... infect children. ,The infant girl was taken to ...
... took part in a "Running of the Nudes" Thursday to ... Spanish town of Pamplona . ,The demonstrators ran ... as the traditional red bandana worn by those who take ... of the bulls involves the release of bulls every morning ...
... Hippel-Lindau disease may suddenly experience hearing loss because of a ... study in the July 4 issue of JAMA. ... sporadically but may be associated with von Hippel-Lindau disease (VHL; ... tumors in the retina of the eye and in the ...
... felt the desire to imbibe reported fewer heavy drinking days ... pill, but both groups reported marked reductions in heavy drinking ... heavy drinkers in Finland, who took either a placebo or ... has a robust and sustained effect in reducing harmful heavy ...
... is just no end to bizarre things that can happen in ... ,A 3-year-old girl is attacked savagely by her mothers boyfriend, ... some treatment for the poor child, but she would not betray ... are arrested. ,,New Bedford police in Massachusetts announced Wednesday ...
Cached Medicine News:Health News:New "second-line" AIDS Drug Shows Promise in Trials 2Health News:US Baby Dies of Salmonella from Pet Turtle 2Health News:Genetic Disease Causes hearing loss 2Health News:New Strategy to Counter Problem Drinking 2Health News:New Strategy to Counter Problem Drinking 3Health News:Boyfriend Bites Off Lip and Ear of 3-year-old Daughter of His Girlfriend 2
(Date:9/15/2014)... 15, 2014 myMatrixx has extended its contract ... with an expanded role that includes direct involvement in ... a nationally recognized physiatrist and pain management specialist, published ... and workers, compensation, is Board Certified in physical medicine ... of Pain Medicine and subspecialty boarded by the American ...
(Date:9/15/2014)... The Society of Corporate Compliance and ... than 4,500 compliance and ethics professionals from across ... corporate fines and settlements.  The SCALENDAR is designed ... ready reference to demonstrate to employees the consequences ... to help compliance and ethics officers looking for ...
(Date:9/15/2014)... 15, 2014 Research and Markets ... Transfer Systems to 2020" report to their offering. ... to humans has been receiving increasing amounts of scrutiny ... become more clearly understood. For caregivers and their patients, ... attempts to mitigate exposure to cytotoxic drugs is clinical ...
Breaking Medicine Technology:myMatrixx Announces Expanded Role for Medical Director Steven P. Stanos, Jr., DO 2More than $55 billion in fines and settlements added by SCCE to its 2015 Corporate Scandal Calendar 2Closed Drug Transfer Systems to 2020 2Closed Drug Transfer Systems to 2020 3
... Nov. 5, 2010 EnVivo Pharmaceuticals today announced it ... agonist, possesses a novel mechanism not previously seen in ... Acetylcholine (ACh) to enhance cognition. By acting ... makes it possible for smaller amounts of naturally occurring ...
... Nov. 5, 2010 Cadence Pharmaceuticals, Inc. (Nasdaq: ... developing and commercializing proprietary product candidates principally for use ... the three and nine months ended September 30, 2010. ... U.S. Food and Drug Administration (FDA) approved OFIRMEV™ (acetaminophen) ...
Cached Medicine Technology:EnVivo Pharmaceuticals Research Shows EVP-6124 Acts as Acetylcholine Co-Agonist 2EnVivo Pharmaceuticals Research Shows EVP-6124 Acts as Acetylcholine Co-Agonist 3Cadence Pharmaceuticals Reports Third Quarter 2010 Financial Results 2Cadence Pharmaceuticals Reports Third Quarter 2010 Financial Results 3Cadence Pharmaceuticals Reports Third Quarter 2010 Financial Results 4Cadence Pharmaceuticals Reports Third Quarter 2010 Financial Results 5Cadence Pharmaceuticals Reports Third Quarter 2010 Financial Results 6
... the corrosion resistance of stainless steel ... copper, SANYO offers an electro-polished copper-alloy-stainless ... maintenance-free. The sterile environment promotes the ... and the safety of laboratory staff. ...
ArcticTemp Upright Freezer -20C. Quick, even freezing. Heavy duty compressor. Deep door racks. Front gated bottom shelf. Interior light. Locks One year warranty on unit and 5 year warranty on compres...
Undercounter Freezer -25C. White. Front opening freezer. 4 cubic ft capacity. Reversible door. Three slide-out drawers. Extra thick CFC insulation. Front lock. Front indicator lights. Attractive tabl...
... F 265 is a highly accurate portable, waterproof ... temperature measurements. Temperature compensated pH results can be ... or a 3-in-1 electrode. • This GLP/GMP compliant ... a printer or a computer. Up to 100 ...
Medicine Products: