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Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
Date:4/21/2010

in the bud."

To confirm the in vitro results, the team has treated mice that are genetically predisposed to develop colorectal adenomas with NO-naproxen and naproxen and are awaiting the results of this study.

NSAIDs have been shown to reduce the risk of colon cancer and precancerous polyps in people. However, some of the agents have been taken off the market due to cardiovascular toxicity. With that in mind, Clapper says, "If we can find something in the same arena that is effective and nontoxic, it will be extremely valuable."

NO-naproxen and other NO-donating NSAID derivatives are a new class of agents being developed with the aim of reducing gastrointestinal toxicity, a relatively common side effect associated with NSAIDs.


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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

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