Navigation Links
Researchers show that lipid nanoparticles are ideal for delivering genes and drugs
Date:2/28/2013

This press release is available in Spanish.

At the Faculty of Pharmacy of the Basque Public University (UPV/EHU) the Pharmacokinetics, Nanotechnology and Gene Therapy research team is using nanotechnology to develop new formulations that can be applied to drugs and gene therapy.Specifically, they are using nanoparticles todesignsystems for delivering genes and drugs; this helps to get the genes and drugs to the point of action so that they can produce the desired effect.

The research team has shown that lipid nanoparticles, which they have been working on for several years, are ideal for acting as vectors in gene therapy.Gene therapy is a highly promising alternative for diseases that so far have no effective treatment.It consists of delivering a nucleic acid, for example, a therapeutic gene, to modulate the expression of a protein that is found to be altered in a specific disease, thus reversing the biological disorder.

The main obstacle is that the genetic material cannot be formulated in conventional pharmaceutical ways, because it becomes degraded within the organism and cannot perform its function.To overcome this obstacle, viral vectors are normally used and they are able to deliver the therapeutic gene to the cells in which it has to act.However, as Dr Alicia Rodriguez explains, "viral vectors have a great drawback because they have a great potential to develop tumours.That is why there is a lot of interest in developing non-viral vectors, like vectors based on lipid nanoparticles."

"In this respect," adds Dr Rodriguez, "we have for several years been working to develop formulations for treating degenerative retina diseases, diseases for which there is currently no effective curative or palliative treatment and which causes blindness in the patients who in many cases are very young people."The research they have done has borne fruit already, and they have in fact managed to develop a vector capable of making a protein express itself in the eyes of rats after ocular delivery.The work has produced two patents and various papers published in top scientific journals, like Human Gene Therapy.

Aim:to improve drug absorption

Another application of lipid nanoparticles is to develop new formulations to deliver drugs that are not particularly soluble or which are difficult to absorb.Dr Rodriguez explained the problem with these drugs:"40% of the new pharmacologically active molecules are reckoned to be insoluble or not very soluble in water; that prevents many of these potentially active molecules from ever reaching the clinic because of the problems involved in developing a safe, effective formulation."

The Faculty of Pharmacy's research team has shown that the strategy of encapsulating drugs of this type in lipid nanoparticles is effective:"They are spheres made of lipids and they have very small particleswhich encase the drug.That way, the absorption of the drug given orally can be increased," points out Dr Rodriguez.

Part of the research was done in collaboration with the research team led by DrVroniquePrat, of the Catholic University of Louvain in Belgium.There they studied the capacity of the nanoparticles to pass through the intestinal barrier and therefore increase the permeability of the drug.The results of this work have been published in the Journal of Controlled Release, a leading journal within the specialty.

Furthermore, while considerable advances have been made in both areas (vectors for gene therapy and improvement in insoluble drug absorption), the researchers in the Pharmacokinetics, Nanotechnology and Gene Therapy team are working in a third area linked to hepatitis C in which they also hope to achieve positive results.
'/>"/>

Contact: Aitziber Lasa
a.lasa@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert  

Related medicine news :

1. Researchers at the UH Cancer Center discover protein that may control the spread of cancer
2. Now hear this: Stanford researchers identify forerunners of inner-ear cells that enable hearing
3. Researchers explore PKC role in lung disease
4. Baylor University researchers study barriers, resources to physical activity in Texas towns
5. Researchers identify variations in 4 genes associated with an increased risk of colorectal cancer
6. Researchers identify variations in four genes associated with an increased risk of colorectal cancer
7. NIH-funded researchers begin trial of Shigella vaccine candidates
8. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
9. Researchers guardians of trust in biobank research
10. Researchers Detect an Anti-Autism Advantage in Females
11. Einstein researchers present on imaging advances
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers show that lipid nanoparticles are ideal for delivering genes and drugs
(Date:9/25/2017)... ... September 25, 2017 , ... ... technology-enabled services supporting clinical research, today announces that 30 of its domain ... the drug development lifecycle at upcoming industry conferences and webinars. Drawing on ...
(Date:9/25/2017)... ... September 25, 2017 , ... Earlypicker is expanding its offerings ... shop for the hottest Korean cosmetics and fashion trends sweeping the nation. The decision ... already well-known for the great offerings that allow Koreans everywhere to look their best ...
(Date:9/25/2017)... , ... September 25, 2017 , ... “The Majestic Unicorn”: ... the great flood. “The Majestic Unicorn” is the creation of published author, Dayna Chantel, ... small, came from far and wide to march aboard the cypress ark-vessel. Male and ...
(Date:9/25/2017)... Philadelphia, PA (PRWEB) , ... September 25, 2017 , ... Emerald Ash Borers ... pest's destruction can be seen throughout the Philadelphia region. A video by Rob Nagy, ... is lined with Ash trees. While several are dead or showing signs of decline ...
(Date:9/24/2017)... ... ... Throughout the United States and the world, clinicians take a simple but ... providers work to give the best care possible to patients and communities, while seeking ... are threatening to tie our hands in carrying out that oath. The Graham-Cassidy legislation ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... 2017 ... coming to Washington DC ... Tuesday, September 12 th – Monday, September 18 th .The Brain ... MRI brain scans to the public.Where:  BTF,s Mobile ... 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road ...
(Date:9/9/2017)... 9, 2017  Eli Lilly and Company (NYSE: ... endpoint data for lasmiditan, an investigational, oral, first-in-class molecule ... significant improvements compared to placebo in the Phase 3 ... the 18th Congress of the International Headache Society (IHC) ... data presented today demonstrate lasmiditan,s potential to reduce pain ...
(Date:9/7/2017)... -- For nearly two decades, New Life Agency has been committed to providing ... New Life Agency announces a powerful three-way partnership designed to deliver substantial ... ... http://www.schrafts2.com/ ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ...
Breaking Medicine Technology: