Navigation Links
Researchers see differences in Autism brain development as early as 6 months

New York, N.Y. -- The changes in brain development that underlie autism spectrum disorder (ASD) may be detectable in children as young as 6 months, according to research reported online today in the American Journal of Psychiatry. While core behaviors associated with ASD (impaired social communication and repetitive behaviors) tend to be identified after a baby's first birthday, researchers found clear differences in brain communication pathways as early as 6 months in infants who later received a definitive diagnosis of ASD.

As part of the Infant Brain Imaging Study (IBIS), senior author Joe Piven, M.D., director of the University of North Carolina's Carolina Institute for Developmental Disabilities in Chapel Hill, and his colleagues studied early brain and behavior development in 92 infants. These infants had older siblings on the autism spectrum and, so, were at elevated risk of developing ASD themselves.

"These results offer promise that we may one day be able to identify infants at risk for autism before the behavioral symptoms are present," says study co-author Geri Dawson, Ph.D., Autism Speaks chief science officer. "The goal," she adds, "is to intervene as early as possible to prevent or reduce the onset of disabling symptoms." One promising area of follow-up research is to identify the specific genetic and biological mechanisms behind the observed differences in brain development.

In their report, the researchers describe using a magnetic resonance imaging technology called diffusion tensor imaging to evaluate the brains of infants at 6 months, 1 year and 2 years of age. This allowed them to create three-dimensional pictures showing changes over time in each infant's "white matter." White matter represents the part of the brain that is particularly rich in the nerve fibers that form major information pathways between different brain regions.

The 28 infants who went on to develop ASD showed different white matter development for 12 of the 15 major brain pathways studied compared with 64 infants who did not go on to develop ASD. At 6 months, there was evidence that the white matter fiber tracts were different in infants who later developed ASD from those of infant siblings who did not develop ASD, and over time it appears that there is a slowing in white matter development. It is a brain marker that differs in children who go on to be classified with autism. These developmental differences may suggest slower white matter development during early childhood, when the brain is making and strengthening vital connections.

"It's too early to tell whether the brain imaging techniques used in the study will be useful in identifying children at risk for ASD in early infancy," Piven says. "But the results could guide the development of better tools for predicting the risk that a child will develop ASD and perhaps measuring whether early intervention therapies improve underlying brain biology."

This work was supported by grants from the National Institutes of Child Health and Development, Autism Speaks and the Simons Foundation. Further support was provided by the National Alliance for Medical Image Computing, funded by a National Institute of Biomedical Imaging and Bioengineering grant. With funding from Autism Speaks, the IBIS team is also looking at the genetic and environmental influences on brain and behavior development in these high-risk infants.

Contact: Jane E. Rubinstein
Autism Speaks

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
Related Image:
Researchers see differences in Autism brain development as early as 6 months
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative ... has initiated cultivation and processing operations at its production facility, and opened its ... Puradigm is the manufacturer of a complete system of proactive air and surface ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... National recruitment ... a life sciences executive with extensive sequencing and genomics experience, as Vice President of ... position, Ms. Hill will be responsible for leading the sales team in the commercialization ...
(Date:6/24/2016)... Gaithersburg, MD (PRWEB) , ... June 24, 2016 ... ... and protocols for human induced pluripotent stem (iPS) cells and other difficult to ... PluriQ™ G9™ Cloning Medium. The PluriQ™ G9™ Gene Editing System is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
Breaking Medicine Technology: