Navigation Links
Researchers see BPA effects in monkey mammary glands

PULLMAN, Wash.A new study finds that fetal exposure to the plastic additive bisphenol A, or BPA, alters mammary gland development in primates. The finding adds to the evidence that the chemical can be causing health problems in humans and bolsters concerns about it contributing to breast cancer.

"Previous studies in mice have demonstrated that low doses of BPA alter the developing mammary gland and that these subtle changes increase the risk of cancer in the adult," says Patricia Hunt, a geneticist in Washington State University's School of Molecular Biosciences. "Some have questioned the relevance of these findings in mice to humans. But finding the same thing in a primate model really hits uncomfortably close to home."

The research appears in the latest Proceedings of the National Academies of Sciences. Hunt and Tufts University School of Medicine researchers Ana Soto and Carlos Sonnenscheinall pioneers in the effects of BPAco-designed the study with Catherine VandeVoort at the University of California at Davis, where the study was performed.

The Tufts researchers compared the structure of newborn mammary glands from BPA-exposed and unexposed female rhesus macaques. Pregnant monkeys were fed a piece of fruit containing a small amount of BPA each day during the gestational period corresponding to the human third trimester of pregnancy, resulting in blood levels of BPA comparable to those of many Americans today.

The researchers found that, at birth, the density of mammary buds was significantly increased in BPA-exposed monkeys, and the overall development of the mammary gland was more advanced compared to unexposed monkeys. Previous studies in the Soto and Sonnenschein laboratories have shown that exposing rodents to tiny amounts of BPA can alter mammary gland development, leading to pre-cancerous and cancerous lesions when the animals exposed in utero reach adult age.

The researchers say the primate research makes them confident that the rodent mammary gland is a reliable model to study developmental exposures to chemicals like BPA that disrupt a mammal's estrogen activity.

"This study buttresses previous findings showing that fetal exposure to low xenoestrogen levels causes developmental alterations that in turn increase the risk of mammary cancer later in life," says Soto. "Because BPA is chemically related to diethylstilbestrol, an estrogen that increased the risk of breast cancer in both rodents and women exposed in the womb, the sum of all these findings strongly suggests that BPA is a breast carcinogen in humans and human exposure to BPA should be curtailed."


Contact: Pat Hunt
Washington State University

Related medicine news :

1. Geisel researchers sift through junk to find colorectal cancer clues
2. Email vacations decrease stress, increase concentration, researchers say
3. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
4. CNIO researchers describe new functions of cohesin relevant for human disease
5. Biomedical researchers receive Hartwell Foundation awards
6. Kessler Foundation researchers present at first International Congress on Cognition in MS
7. Researchers gain better understanding of mechanism behind tau spreading in the brain
8. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
9. Researchers determine vitamin D blood level for reducing major medical risks in older adults
10. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
11. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
Post Your Comments:
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... According to ... surgical robot is being more and more widely heralded as a breakthrough for performing ... Vinci method has over traditional laparoscopic surgery is that it can greatly reduce the ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... people across the country to celebrate their sobriety and show through pictures what ... “before and after” photos this Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would like to become more ... to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be ... As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 25, 2015, officials of ... network, announced the release of a new cutting edge recovery program that has been ... working with drug- and alcohol-addicted individuals with the purpose to free addicts from the ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... N.Y. , Nov. 25, 2015  Linden Care, ... and optimizing treatment outcomes for patients suffering from chronic ... request for a Temporary Restraining Order (TRO) enjoining Express ... the two companies. --> ... pursuing all of its legal options. ...
(Date:11/25/2015)... WILMINGTON, N.C. , Nov. 25, 2015 /PRNewswire/ ... announces the planned investment of at least $15.8 ... in Wilmington, NC . The ... services capacity to meet the growing demands of ... Wilmington site expansion will provide up ...
(Date:11/25/2015)... -- On Tuesday, November 24, 2015, the jury ... Medical Technology, Inc. for product liability and misrepresentation ... device, awarded $11 million in favor of Plaintiff ... three days of deliberations, the jury found that ... and unreasonably dangerous, and that Wright Medical made ...
Breaking Medicine Technology: