Navigation Links
Researchers search for culprit behind dry eyes, mouths and more
Date:11/21/2011

Researchers want to find the main culprit behind the dry, irritated eyes, mouth, throat, skin, nose and more afflicting 1-3 percent of the population.

It's called Sjgren's syndrome, a painful condition affecting moisture production that takes an average of 6.5 years to diagnose and is difficult to treat. Georgia Health Sciences University researchers say learning more about how it develops should improve diagnosis and treatment.

"We want to identify the early events just after onset of the disease so it can be diagnosed more quickly," said Dr. Rafal Pacholczyk, immunologist in the GHSU Center for Biotechnology and Genomic Medicine. "Knowing more about how the disease unfolds also will help us identify more targeted ways to treat it."

Armed with a $1.9 million grant from the National Institutes of Health, he's using a variety of mouse models to parse how the immune system begins to attack saliva, tear and other moisture-producing glands. Sjgren's blocks receptors that activate one or more of these glands, impeding messages from the brain to make tears or saliva. Gland cells also can be destroyed. A key question is which immune cells are to blame for the friendly fire.

It's the dendritic cells that scour the body for invaders, typically taking their finds to the draining lymph nodes to show T cells. Effector T cells can then initiate an attack, such as prompting B cell production of antibodies that, in this case, block receptors and attack cells. Regulatory T cells are supposed to prevent the attack on "self" tissues that occurs in autoimmune diseases such as Sjgren's. Still unidentified genes likely increase disease risk; environmental factors such as an infection may pull the trigger.

Pacholczyk is tracking T cell development in mice that start to develop Sjgren's by 8-10 weeks of age, trying to determine what causes the cells to become harmful.

He wants to identify the T cell receptors that distinguish self fr
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. MU researchers develop tool that saves time, eliminates mistakes in diabetes care
2. Researchers discover new way to form extracellular vesicles
3. Researchers discover Achilles heel in lethal form of prostate cancer
4. Jackson Laboratory researchers uncover steps in synapse building, pruning
5. UCLA stem cell researchers uncover mechanism that regulates human pluripotent stem cell metabolism
6. Ben-Gurion University of the Negev researchers achieve male fertility breakthrough
7. Canadian researchers find potential new leukemia treatment with old antibiotic drug
8. FDA funds Rochester researchers to give chronic and acute pain clinical trials a makeover
9. Jefferson researchers study outcomes of carotid artery stenting following prior carotid procedure
10. Researchers gain insight into 100-year-old Haber-Bbosch process
11. New funding will help researchers learn how preschoolers move, battle early child obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers search for culprit behind dry eyes, mouths and more
(Date:8/3/2015)... ... 03, 2015 , ... Since 1978, the number of black males applying to ... released today by the AAMC (Association of American Medical Colleges). , Despite an ... decades, the number of black male applicants to medical school dropped to 1,337 in ...
(Date:8/3/2015)... Angeles, CA (PRWEB) , ... August 03, 2015 , ... According to an opinion ... calories out of person’s diet leads to one pound of weight loss may not be ... caloric reduction that translates to one pound of fat varies – based both on the ...
(Date:8/3/2015)... ... August 03, 2015 , ... BESLER Consulting today announced the ... , The MarketingProfs Bright Bulb B2B Awards celebrate the best marketing, communications, and ... launch of their Readmissions Analytics product was selected as one of four finalists ...
(Date:8/3/2015)... ... August 03, 2015 , ... A ... while an overwhelming number of Hispanics believe people can positively affect their diabetes, ... of participants queried said making diet changes was important. Far fewer participants mentioned ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... and amputation , AUGUST 3, 2015 – Since winning a South by Southwest® ... Not Impossible – an organization whose mission is to develop technology for the ...
Breaking Medicine News(10 mins):Health News:New Publication Focuses on the Decline of Black Males in Medicine 2Health News:New Publication Focuses on the Decline of Black Males in Medicine 3Health News:New Publication Focuses on the Decline of Black Males in Medicine 4Health News:Article Dispelling Weight Loss Myth Correctly Emphasizes the Complicated and Difficult Nature of Weight Loss, Says Dr. Michael Feiz 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4
... Genetic factors may be at play when it comes ... and vulnerability for depression// , according to a new ... the October issue of the journal Archives of General ... genetic analyses that showed that neuroticism is a strong ...
... Ooteman a Dutch researcher has stumbled upon some very ... of understanding// the biological and genetic characteristics of alcoholics, ... curb the irresistible urge to drink. ,The urge ... like Naltrexone and Acamprosate. The investigations done by the ...
... focus on U.S. soldiers seriously wounded or injured during ... //severity may predict the risk for posttraumatic stress disorder ... 2006 issue of The American Journal of Psychiatry, the ... study written by Thomas A. Grieger, M.D., and colleagues ...
... Manchester Been honored with a prized award for research ... suffer from chronic or acute back pain worldwide. ... Student annually at the Science, Engineering and Technology Student ... Ambury. ,She examined how special ‘Braces’ or ...
... immigration detention centers has been accused of providing inadequate ... the prison watchdog.// ,Chief Inspector of Prisons ... Wood Immigration Removal Centre in Bedfordshire following concerns raised ... Uganda. ,Although Owers praised the work of ...
... research reported that ragweed or hay fever symptoms could be ... vaccine developed at Johns Hopkins in Baltimore. ,Dr. ... and Allergy Center at the Johns Hopkins University School of ... fall ragweed seasons in Baltimore. ,The study was ...
Cached Medicine News:Health News:Link Between Neuroticism and Depression May be Genetic 2Health News:DNA vaccine for ragweed allergies 2
(Date:8/3/2015)... Pa. , Aug. 3, 2015 VWR ... laboratory products, services and solutions, announces the redesign of its ... customers. When visiting the new site, guests ... with bold colors and vivid images.  Each country site now ... an A to Z product menu; and , the ...
(Date:8/3/2015)... SPRINGS, Florida , August 3, 2015 /PRNewswire/ ... HOLD -- FN Media Group LLC, PIV757417 The ... Focus on Developing Orphan Drug Products & Treatments ... now OFF HOLD. Distribution time: 3 Aug 2015 ... agreements between biotech companies, military surgical research and ...
(Date:8/3/2015)... 2015  Charleston Laboratories, Inc., an emerging specialty ... development program with a Phase 1 study on ... CL-H1T contains fast-dissolving promethazine and sumatriptan.  This novel ... for migraine headache pain and migraine-induced nausea and ... migraine headaches also suffer from nausea and vomiting," ...
Breaking Medicine Technology:VWR's New Website Redesign Provides Improved Functionality for Customers 2/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 2/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 3/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 4/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 5/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 6Charleston Laboratories, Inc. Initiates Patient Enrollment in a Phase 1 Study of Charleston's Second Product, CL-H1T 2
... , AUSTIN, Texas, Dec. 9 Ascension ... recent hiring of two veteran executives, L. Robert Johnston, Jr. ... Vice President of Marketing. "These individuals bring a wealth of ... future growth of Ascension," said Guy Mayer, CEO. "As members ...
... Dec. 9 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX ) ... to the Company,s Board of Directors. Dr. Sanders brings ... physician and professor of medicine. , "We are ... said Zola P. Horovitz, Ph.D., Chairman of the Board of ...
Cached Medicine Technology:Ascension Orthopedics Hires Key Senior Executives 2BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 2BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 3BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 4
... Designed for High Throughput Screening (HTS), ... assays into HTS by sharing all ... of Analyst AD, fluorescence intensity, fluorescence ... Optimized for seamless integration into robotic ...
... for cell-based assays, the NOVOstar provides both ... the flexibility of an on-board reagent pipet. ... to plate or from three reagent stations ... unit has two injectors that can accurately ...
... High sensitivity and ... for eight different radiometric ... first system with true ... radiometric assays, by exploiting ...
This a new dedicated VICTOR2 model for fluorescence, fluorescence polarization and luminescence measurement with stacker and robotic loading....
Medicine Products: