Navigation Links
Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
Date:9/17/2012

NEW YORK (Sept. 17, 2012) -- The power of taxane-based chemotherapy drugs are misunderstood and potentially underestimated, according to researchers at Weill Cornell Medical College in the September 15 issue of the journal Cancer Research.

Most physicians and investigators believe that taxane chemotherapy (paclitaxel, docetaxel and cabazitaxel) just does one thing -- stop a cancer cell from dividing -- but the team of Weill Cornell scientists have revealed it acts much more powerfully and broadly, especially against prostate cancer.

"Taxanes are one of the best class of chemotherapy drugs that we can use to treat our cancer patients, but while they are effective against a wide range of tumors, they don't work in all of them, and often patients become resistant," says the study's senior investigator, Dr. Paraskevi Giannakakou, an associate professor of pharmacology in medicine and pharmacology and director of laboratory research for the Division of Hematology and Medical Oncology at Weill Cornell. "However, our new understanding of the precise action of taxanes in a cancer cell may help us overcome drug insensitivity or acquired resistance to the drugs and design therapies that can be used in combination with them to improve cancer control."

In their study, the researchers stress that investigators must shift their attention away from taxane's function during cell division to the drugs' effects on halting the everyday movement of proteins and protein-to-protein communication within cancer cells -- and to understanding how and why a cancer cell can still survive. Researchers suggest that cancers that are insensitive to taxanes -- or those that have become resistant to them -- may, for example, switch to alternate forms of "transportation" to shuttle proteins within cells in a way that does not depend on the cell's skeletal structure which is the target of taxane therapy.

Researchers showed in the study that the androgen
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... NY (PRWEB) , ... July 29, 2015 , ... CanAm ... approved by USCIS over the past month! I-829 approvals have been granted to investors ... Los Angeles, the Kimpton Lafayette Hotel project in Philadelphia, and the Valley Forge ...
(Date:7/29/2015)... ... July 29, 2015 , ... A June 10, 2015 article from the ... discussed the importance of having regular skin cancer screenings from an early age. Skin ... ultraviolet rays. When caught early, skin cancer is rarely fatal; however, if left alone ...
(Date:7/29/2015)... ... 29, 2015 , ... Several years ago, in order to be in the ... took a proactive stance and began planning the Children’s Village consisting of six homes. ... to building the third home. , “We are very pleased to have received the ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... a “forward thinker.” Since the late 1970s, Dr. Cottrell has been making predictions ... book, The New Earth, documents many of these prognostications. He warns that extreme ...
(Date:7/29/2015)... ... July 29, 2015 , ... National non-profit ... of life insurance, annuities, employee benefits and asset management, has joined as presenting ... event taking place in Charlotte, North Carolina on October 2-4, 2015. , Hosted ...
Breaking Medicine News(10 mins):Health News:More Than 60 New I-829 Approvals in Less Than 30 days for CanAm 2Health News:More Than 60 New I-829 Approvals in Less Than 30 days for CanAm 3Health News:Get Checked for Skin Cancer Early and Often 2Health News:Get Checked for Skin Cancer Early and Often 3Health News:Little City Receives $500,000 Matching Grant from The Coleman Foundation 2Health News:Little City Receives $500,000 Matching Grant from The Coleman Foundation 3Health News:Author Warns Public to Prepare for Imminent Environmental Disaster 2Health News:MetLife Joins World T.E.A.M. Sports’ Adventure Team Challenge North Carolina as Presenting Sponsor 2Health News:MetLife Joins World T.E.A.M. Sports’ Adventure Team Challenge North Carolina as Presenting Sponsor 3
... ... that Offer Style and Comfort at myShoes.com , ... (Vocus) May 18, 2010 -- myShoes.com , a new search ... According to health experts, ligaments in a woman’s lower back soften while pregnant and ...
... Patients, including many veterans, are at 8 times the risk ... News) -- People who are hospitalized for a traumatic brain ... major depression. , That,s the finding of a team led ... University of Washington School of Medicine in Seattle and first ...
... Institute of General Medical Sciences (NIGMS) of the ... of Missouri researchers $1.18 million to further develop ... MULTICOM. Using this system to understand protein structures ... a variety of diseases. "Proteins are fundamental ...
... Dr.Khanna helped ... ... Angeles Lasik surgeon Dr. Rajesh Khanna. Sherri found it was necessary to take care of the ... Sherri was impressed with the care and results of the LASIK surgery of her husband ...
... in German . Ball lightnings are ... large class of reports by eyewitnesses having experienced such events. ... fire balls for a long time. Now physicists at the ... long lightning strokes may produce the image of luminous shapes, ...
... ... since Scripps Health founded San Diego County’s first blood and marrow transplantation ... ... -- The outlook for patients with leukemia and other life-threatening blood cancers has improved ...
Cached Medicine News:Health News:MyShoes.com, a New Search Engine for Women's Shoes, Features Chic Shoes for Expectant Mothers 2Health News:MyShoes.com, a New Search Engine for Women's Shoes, Features Chic Shoes for Expectant Mothers 3Health News:Major Depression Often Follows Brain Injury 2Health News:Major Depression Often Follows Brain Injury 3Health News:System that predicts protein structures could help researchers design drugs 2Health News:Dr.Khanna is a Hero, Says Hero Actor 2Health News:Dr.Khanna is a Hero, Says Hero Actor 3Health News:Mysterious ball lightning: Illusion or reality? 2Health News:Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care 2Health News:Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care 3Health News:Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care 4Health News:Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care 5
(Date:7/29/2015)... Commenting on GSK,s Q2 performance, the first ... reveals sales rose during the period and that ... Ahead of a November R&D update day he reiterates ... interview and transcript are available now on http://video.merchantcantos.com ... webcasts with senior company executives. If you would like ...
(Date:7/29/2015)... July 29, 2015 Cogentix Medical, Inc. (NASDAQ: ... urology market, will release financial results for the first quarter ... the market close on Monday, August 10, 2015. ... to discuss these results on Monday, August 10, 2015 at ... Kill , President and Chief Executive Officer, and Brett ...
(Date:7/29/2015)... 2015  Cepheid (Nasdaq: CPHD ) today ... Xpert® Carba-R, with the addition of two newly ... molecular test also detects and differentiates among the ... KPC, NDM, VIM, IMP-1 and OXA-48. ... Superbugs, are a growing and expensive challenge for ...
Breaking Medicine Technology:Cogentix Medical to Announce First Quarter Fiscal 2016 Results on August 10, 2015 2'Superbug' Test Updated to Identify Newest Carbapenem-Resistant Organisms 2'Superbug' Test Updated to Identify Newest Carbapenem-Resistant Organisms 3'Superbug' Test Updated to Identify Newest Carbapenem-Resistant Organisms 4
... 2011 Accuray Incorporated (Nasdaq: ARAY ... today the first published five-year outcomes on low risk ... Radiosurgery System . The multi-center study, published in the January ... 93 percent of patients had no recurrence of their cancer ...
... Siemens Healthcare Diagnostics introduces Personalized Education Plan ... model focused exclusively on the individual. Healthcare professionals, ... able to plan a wide variety of product-specific, ... also tracks each individual,s training path, it becomes ...
Cached Medicine Technology:First Five-Year Outcomes Published on CyberKnife Radiosurgery for Prostate Cancer 2First Five-Year Outcomes Published on CyberKnife Radiosurgery for Prostate Cancer 3First Five-Year Outcomes Published on CyberKnife Radiosurgery for Prostate Cancer 4Siemens Launches PEP, a Personalized Education Plan for Clinical Laboratory and Healthcare Professionals 2Siemens Launches PEP, a Personalized Education Plan for Clinical Laboratory and Healthcare Professionals 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: