Navigation Links
Researchers reveal most effective treatment for common kidney disorder
Date:1/9/2013

The results of a pioneering UK-wide clinical trial that compared treatments for patients with a common type of kidney disease has found one to be significantly more effective. The results of the study, published online in The Lancet today [9 Jan], will be recommended to clinicians worldwide as the most effective approach to treating the condition.

The Medical Research Council-funded study, led by researchers from the University of Bristol's Academic Renal Unit based in Southmead Hospital, compared three treatment approaches in a type of kidney disorder known as 'membranous nephropathy'.

The condition, which leads to changes and inflammation of the structures inside the kidney that help filter wastes and fluids, is usually managed with immunosuppressive drugs but has a high risk of causing kidney failure in patients. Previous studies of the disorder, which is costly to treat (kidney failure treatments cost $40 billion in the US in 2008), show that once kidney function starts to decline, continued deterioration can be expected.

The research team, led by Professor Peter Mathieson, Dean of the Faculty of Medicine and Dentistry, carried out a randomised controlled trial involving 108 patients with 20 per cent decline in renal function at 37 renal units across the UK. The patients were randomised to one of three treatment approaches and followed up by the team over three years.

The team evaluated results from 33 patients who were treated with prednisolone and chlorambucil, 37 patients with ciclosporin and 38 who were provided with supportive therapy alone.

They found that for patients with membranous nephropathy, six months' therapy with alternating monthly cycles of prednisolone and chlorambucil was the most effective option. This approach was shown to be the most effective in preventing further renal decline in patients with the benefits maintained over the three-year study period and thus the recommended treatment approach.

Professor Mathieson, the study's lead author and Dean of the Faculty of Medicine and Dentistry at the University, said: "Kidney failure is a devastating condition that is difficult and expensive to treat and our best strategies are to aim to prevent it wherever possible by more effective treatment of the underlying kidney problems. This clinical trial took a very long time to complete and I was helped by kidney specialists, research nurses and patients in Bristol and all over the UK. The results improve the evidence-base for our treatments in this form of kidney disease."


'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Related medicine news :

1. Researchers identify new target for common heart condition
2. USF and VA researchers find long-term consequences for those suffering traumatic brain injury
3. Pesticides and Parkinsons: UCLA researchers uncover further proof of a link
4. Mayo Clinic researchers find new molecule to target in pancreatic cancer treatment
5. Researchers zero in on cognitive difficulties associated with menopause
6. Common data determinants of recurrent cancer are broken, mislead researchers
7. Researchers identify an early predictor for glaucoma
8. PolyU Researchers Develop Novel Treatment for People with Hemiplegic Arms
9. A Serious Problem: Medical Malpractice Lawyers at Console & Hollawell React to Alarming Doctor Error Statistics from Johns Hopkins University Researchers
10. U of T Researchers uncover major source of evolutionary differences among species
11. MRIs reveal signs of brain injuries not seen in CT scans, UCSF/SFGH researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... DC (PRWEB) , ... April 28, 2017 , ... ... Pregnancy (The National Campaign) announces its support for the Access to Contraception ... Sen. Jeanne Shaheen (D-NH) and Rep. Jackie Speier (D-CA), will help to ensure ...
(Date:4/28/2017)... ... April 28, 2017 , ... Somnoware, a leading ... Word(TM) Online(TM), which enables sleep physicians to create and edit their interpretation reports. ... and provides a familiar interface that does not require additional training to use. ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... Getting enough sleep affects much more than ... (NSF), going just 19 hours without sleep can compromise motor reaction time, which can increase ... and Amica Insurance is sharing the following tips from the NSF to help you sleep ...
(Date:4/28/2017)... Cypress, California (PRWEB) , ... April 28, 2017 ... ... LED T8 Direct Replace tubes . These lamps offer an instant energy-saving solution ... no need to rewire fixtures or disconnect ballasts. These 50,000 hour rated lamps ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children ... to more adverse experiences than children in the general population. That’s because foster ... neglect or other family challenges. While no fault of their own, youth who ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... WOONSOCKET, R.I. , April 20, 2017 /PRNewswire/ ... (NYSE: CVS), today unveiled a new store design ... new assortment of healthier food, health-focused products and ... the store to help customers discover new offerings. ... represent the next evolution of the customer experience ...
(Date:4/20/2017)... -- AbbVie (NYSE: ABBV), a global biopharmaceutical company, today ... C virus (HCV) infected patients with genotype 1, ... (Child-Pugh A) achieved sustained virologic response at 12 ... pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). These high SVR ... of G/P treatment without ribavirin. Patients with specific ...
(Date:4/20/2017)... April 20, 2017 Eyevensys, a ... first non-viral gene expression technology that enables the safe, ... to address a wide range of ophthalmic diseases, announces ... Healthcare products Regulatory Agency (MHRA) to advance its technology ... ...
Breaking Medicine Technology: